scholarly journals Magnetic Resonance Spectroscopy of Hepatic Fat from Fundamental to Clinical Applications

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 842
Author(s):  
Duanghathai Pasanta ◽  
Khin Thandar Htun ◽  
Jie Pan ◽  
Montree Tungjai ◽  
Siriprapa Kaewjaeng ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Liver Steatosis ◽  
High Sensitivity ◽  
Liver Fat ◽  
Resonance Spectroscopy ◽  
Current State ◽  
Hepatic Fat ◽  
Areas Of Interest

The number of individuals suffering from fatty liver is increasing worldwide, leading to interest in the noninvasive study of liver fat. Magnetic resonance spectroscopy (MRS) is a powerful tool that allows direct quantification of metabolites in tissue or areas of interest. MRS has been applied in both research and clinical studies to assess liver fat noninvasively in vivo. MRS has also demonstrated excellent performance in liver fat assessment with high sensitivity and specificity compared to biopsy and other imaging modalities. Because of these qualities, MRS has been generally accepted as the reference standard for the noninvasive measurement of liver steatosis. MRS is an evolving technique with high potential as a diagnostic tool in the clinical setting. This review aims to provide a brief overview of the MRS principle for liver fat assessment and its application, and to summarize the current state of MRS study in comparison to other techniques.

scholarly journals In Vivo Measurement of Carbon-13 Labeling of Glutamate and Glutamine in Human Brain Using Proton Magnetic Resonance Spectroscopy

2020 ◽  
Author(s):  
Li An ◽  
Shizhe Li ◽  
Maria Ferraris Araneta ◽  
Milalynn Victorino ◽  
Christopher Johnson ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Oral Administration ◽  
High Sensitivity ◽  
Single Step ◽  
Anterior Cingulate ◽  
Resonance Spectroscopy ◽  
Dorsal Anterior Cingulate Cortex ◽  
In Vivo Measurement

Abstract A single-step spectral editing 1H magnetic resonance spectroscopy (MRS) technique was used to measure fractional enrichments of glutamate and glutamine in the dorsal anterior cingulate cortex of five healthy volunteers after oral administration of [U-13C]glucose. Strong pseudo singlets of glutamate and glutamine were induced at an echo time of 56 ms using an always-on editing pulse at 2.12 ppm. At 113 ± 9 minutes after oral administration of [U-13C]glucose, fractional enrichment of glutamate was found to be 64 ± 5% with 1.7% within-subject coefficient of variation (CV) and fractional enrichment of glutamine was found to be 40 ± 10% with 11% within-subject CV. This study demonstrated that 13C labeling of both glutamate and glutamine can be measured with the high sensitivity and spatial resolution of proton MRS using a proton-only MRS technique with standard commercial hardware. Furthermore, it is now feasible to measure 13C labeling of glutamate and glutamine in limbic structures, which play major roles in behavioral and emotional responses and whose abnormalities are involved in many neuropsychiatric disorders.

Biological NMR Spectroscopy

1997 ◽  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
State Of The Art ◽  
Critical Assessment ◽  
Resonance Spectroscopy ◽  
History Of ◽  
Structure Of Proteins

This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.

In vivo 2D J-resolved magnetic resonance spectroscopy of rat brain with a 3-T clinical human scanner

NeuroImage ◽  
2004 ◽  
Vol 22 (1) ◽  
pp. 381-386 ◽  
Author(s):  
E Adalsteinsson ◽  
R.E Hurd ◽  
D Mayer ◽  
N Sailasuta ◽  
E.V Sullivan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Rat Brain ◽  
Resonance Spectroscopy

scholarly journals INSPECTOR: free software for magnetic resonance spectroscopy data inspection, processing, simulation and analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Martin Gajdošík ◽  
Karl Landheer ◽  
Kelley M. Swanberg ◽  
Christoph Juchem
Keyword(s):  
Magnetic Resonance ◽  
Quality Management ◽  
Magnetic Resonance Spectroscopy ◽  
Data Processing ◽  
Biomedical Research ◽  
Clinical Diagnostics ◽  
Resonance Spectroscopy ◽  
User Friendliness ◽  
Wide Range

AbstractIn vivo magnetic resonance spectroscopy (MRS) is a powerful tool for biomedical research and clinical diagnostics, allowing for non-invasive measurement and analysis of small molecules from living tissues. However, currently available MRS processing and analytical software tools are limited in their potential for in-depth quality management, access to details of the processing stream, and user friendliness. Moreover, available MRS software focuses on selected aspects of MRS such as simulation, signal processing or analysis, necessitating the use of multiple packages and interfacing among them for biomedical applications. The freeware INSPECTOR comprises enhanced MRS data processing, simulation and analytical capabilities in a one-stop-shop solution for a wide range of biomedical research and diagnostic applications. Extensive data handling, quality management and visualization options are built in, enabling the assessment of every step of the processing chain with maximum transparency. The parameters of the processing can be flexibly chosen and tailored for the specific research problem, and extended confidence information is provided with the analysis. The INSPECTOR software stands out in its user-friendly workflow and potential for automation. In addition to convenience, the functionalities of INSPECTOR ensure rigorous and consistent data processing throughout multi-experiment and multi-center studies.

scholarly journals In vivo detection of citrate in brain tumors by1H magnetic resonance spectroscopy at 3T

2013 ◽  
Vol 72 (2) ◽  
pp. 316-323 ◽  
Author(s):  
Changho Choi ◽  
Sandeep K. Ganji ◽  
Akshay Madan ◽  
Keith M. Hulsey ◽  
Zhongxu An ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Tumors ◽  
Resonance Spectroscopy ◽  
In Vivo Detection
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