scholarly journals Comparison of [18F]FDG PET/CT and MRI for Treatment Response Assessment in Multiple Myeloma: A Meta-Analysis

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 706
Author(s):  
Kota Yokoyama ◽  
Junichi Tsuchiya ◽  
Ukihide Tateishi
Keyword(s):  
Multiple Myeloma ◽  
Treatment Response ◽  
Fdg Pet ◽  
Meta Analysis ◽  
Response Assessment ◽  
Pet Ct ◽  
Treatment Response Assessment ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Ct And Mri

The present study was designed to assess the additional value of 2-deoxy-2[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) to magnetic resonance imaging (MRI) in the treatment response assessment of multiple myeloma (MM). We performed a meta-analysis of all available studies to compare the detectability of treatment response of [18F]FDG PET/CT and MRI in treated MM. We defined detecting a good therapeutic effect as positive, and residual disease as negative. We determined the sensitivities and specificities across studies, calculated the positive and negative likelihood ratios (LR), and made summary receiver operating characteristic curves (SROC) using hierarchical regression models. The pooled analysis included six studies that comprised 278 patients. The respective performance characteristics (95% confidence interval (CI)) of [18F]FDG PET/CT and MRI were as follows: sensitivity of 80% (56% to 94%) and 25% (19% to 31%); specificity of 58% (44% to 71%) and 83% (71% to 91%); diagnostic odds ratio (DOR) of 6.0 (3.0–12.0) and 1.7 (0.7–2.7); positive LR of 1.8 (1.3–2.4) and 1.4 (0.7–2.7); and negative LR of 0.33 (0.21–0.53) and 0.81 (0.62–1.1). In the respective SROC curves, the area under the curve was 0.77 (SE, 0.038) and 0.59 (SE, 0.079) and the Q* index was 0.71 and 0.57. Compared with MRI, [18F]FDG PET/CT had higher sensitivity and better DOR and SROC curves. Compared with MRI, [18F]FDG PET/CT had greater ability to detect the treatment assessment of MM.

Usefulness of 18F-FDG PET/CT in Disease Extent and Treatment Response Assessment in a Patient With Syphilitic Aortitis

2013 ◽  
Vol 38 (4) ◽  
pp. e185-e187 ◽  
Author(s):  
Giorgio Treglia ◽  
Silvia Taralli ◽  
Fabio Maggi ◽  
Antonella Coli ◽  
Libero Lauriola ◽  
...  
Keyword(s):  
Treatment Response ◽  
Fdg Pet ◽  
Response Assessment ◽  
Disease Extent ◽  
Pet Ct ◽  
Treatment Response Assessment ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Syphilitic Aortitis

Treatment response assessment in [18F]FDG-PET/CT oncology scans: Impact of count statistics variation and reconstruction protocol

2019 ◽  
Vol 57 ◽  
pp. 177-182 ◽  
Author(s):  
Carlotta Dolci ◽  
Chiara Spadavecchia ◽  
Cinzia Crivellaro ◽  
Elena De Ponti ◽  
Sergio Todde ◽  
...  
Keyword(s):  
Treatment Response ◽  
Fdg Pet ◽  
Response Assessment ◽  
Pet Ct ◽  
Treatment Response Assessment ◽  
18F Fdg ◽  
Fdg Pet Ct

18F-FDG-PET/CT in staging, restaging, and treatment response assessment of male breast cancer

2014 ◽  
Vol 83 (10) ◽  
pp. 1925-1933 ◽  
Author(s):  
David Groheux ◽  
Elif Hindié ◽  
Michel Marty ◽  
Marc Espié ◽  
Domenico Rubello ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Response ◽  
Male Breast Cancer ◽  
Fdg Pet ◽  
Response Assessment ◽  
Male Breast ◽  
Pet Ct ◽  
Treatment Response Assessment ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Indirect comparison of the diagnostic performance of 18F-FDG PET/CT and MRI in differentiating benign and malignant ovarian or adnexal tumors: a systematic review and meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xianwen Hu ◽  
Dandan Li ◽  
Zhigang Liang ◽  
Yan Liao ◽  
Ling Yang ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Meta Analysis ◽  
Indirect Comparison ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Adnexal Tumors ◽  
Ct And Mri

Abstract Objective To compare the value of fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) and magnetic resonance imaging (MRI) in differentiating benign and malignant ovarian or adnexal tumors. Materials and methods English articles reporting on the diagnostic performance of MRI or 18F-FDG PET/CT in identifying benign and malignant ovarian or adnexal tumors published in PubMed and Embase between January 2000 and January 2021 were included in the meta-analysis. Two authors independently extracted the data. If the data presented in the study report could be used to construct a 2 × 2 contingency table comparing 18F-FDG PET/CT and MRI, the studies were selected for the analysis. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used to evaluate the quality of the included studies. Forest plots were generated according to the sensitivity and specificity of 18F-FDG PET/CT and MRI. Results A total of 27 articles, including 1118F-FDG PET/CT studies and 17 MRI studies on the differentiation of benign and malignant ovarian or adnexal tumors, were included in this meta-analysis. The pooled sensitivity and specificity for 18F-FDG PET/CT in differentiating benign and malignant ovarian or adnexal tumors were 0.94 (95% CI, 0.87–0.97) and 0.86 (95% CI, 0.79–0.91), respectively, and the pooled sensitivity and specificity for MRI were 0.92 (95% CI: 0.89–0.95) and 0.85 (95% CI: 0.79–0.89), respectively. Conclusion While MRI and 18F-FDG PET/CT both showed to have high and similar diagnostic performance in the differential diagnosis of benign and malignant ovarian or adnexal tumors, MRI, a promising non-radiation imaging technology, may be a more suitable choice for patients with ovarian or accessory tumors. Nonetheless, prospective studies directly comparing MRI and 18F-FDG PET/CT diagnostic performance in the differentiation of benign and malignant ovarian or adnexal tumors are needed.

18F-FDG PET, combined FDG-PET/CT and MRI for evaluation of bone marrow infiltration in staging of lymphoma: A systematic review and meta-analysis

2012 ◽  
Vol 81 (2) ◽  
pp. 303-311 ◽  
Author(s):  
Lian-Ming Wu ◽  
Fang-Yuan Chen ◽  
Xiao-Xing Jiang ◽  
Hai-Yan Gu ◽  
Yan Yin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Marrow ◽  
Fdg Pet ◽  
Meta Analysis ◽  
Bone Marrow Infiltration ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Ct And Mri

scholarly journals Diagnostic Accuracy of 18F-FDG-PET/CT and MRI in Predicting the Tumor Response in Locally Advanced Cervical Carcinoma Treated by Chemoradiotherapy: A Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Sharareh Sanei Sistani ◽  
Fateme Parooie ◽  
Morteza Salarzaei
Keyword(s):  
Diagnostic Accuracy ◽  
Fdg Pet ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Advanced Cervical Carcinoma ◽  
Pet Ct ◽  
18F Fdg ◽  
Diagnostic Sensitivity And Specificity ◽  
Fdg Pet Ct ◽  
Ct And Mri

Objective. The aim of this meta-analysis was to compare the diagnostic accuracy of 18F-FDG-PET/CT and MRI in predicting the tumor response in locally advanced cervical carcinoma (LACC) treated by chemoradiotherapy (CRT). Method. This meta-analysis has been performed according to PRISMA guidelines. Systematic searches were conducted using PubMed and Embase databases for articles published from January 1, 2010, to January 1, 2020. By using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool, the reviewers assessed the methodological quality scores of the selected studies. We analyzed the sensitivity, specificity, and accuracy of two diagnostic methods using Meta-DiSc 1.4 and Stata 15. Results. An overall of 15 studies including 1132 patients were included. Sensitivities of PET/CT and MRI were 83.5% and 82.7%, while the corresponding rates for specificities were 77.8% and 68.4%, respectively. The DOR, PLR, and NLR for MRI were 15.140, 2.92, and 22.6. PET/CT had a DOR of 25.21. The PLR and NLR for PET/CT were 4.13 and 0.215, respectively. The diagnostic sensitivity and specificity of PET/CT for the detection of residual tumor were 86% and 95%, respectively. The corresponding rates for MRI were 73% and 96%, respectively. The diagnostic sensitivity and specificity of PET/CT for the detection of tumor metastases were 97% and 99%, while the corresponding rates for MRI were 31% and 98%, respectively. Conclusion. 18F-FDG PET/CT seemed to have a better overall diagnostic accuracy in the evaluation of treatment response to chemoradiotherapy in LACC patients. MRI showed a really poor sensitivity in the detection of metastases, and PET/CT performed significantly better. However, the difference between these two methods in the detection of residual disease was not significant. More studies are needed to be conducted in order to approve that 18F-FDG PET/CT can be a standard option to assess the treatment response.

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