scholarly journals Salivary Biomarkers and Oral Health in Liver Transplant Recipients, with an Emphasis on Diabetes

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 662
Author(s):  
Annika Emilia Norrman ◽  
Taina Tervahartiala ◽  
Ella Sahlberg ◽  
Timo Sorsa ◽  
Hellevi Ruokonen ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Liver Transplant ◽  
Dental Treatment ◽  
Molar Ratio ◽  
Periodontal Health ◽  
Salivary Biomarkers ◽  
Periodontal Inflammation ◽  
Matrix Metalloproteinase 1 ◽  
Salivary Biomarker ◽  
Inflammatory State

Salivary biomarkers have been linked to various systemic diseases. We examined the association between salivary biomarkers, periodontal health, and microbial burden in liver transplant (LT) recipients with and without diabetes, after transplantation. We hypothesized that diabetic recipients would exhibit impaired parameters. This study included 84 adults who received an LT between 2000 and 2006 in Finland. Dental treatment preceded transplantation. The recipients were re-examined, on average, six years later. We evaluated a battery of salivary biomarkers, microbiota, and subjective oral symptoms. Periodontal health was assessed, and immunosuppressive treatments were recorded. Recipients with impaired periodontal health showed higher matrix metalloproteinase-8 (MMP-8) levels (p < 0.05) and MMP-8/tissue inhibitor of matrix metalloproteinase 1 (TIMP1) ratios (p < 0.001) than recipients with good periodontal health. Diabetes post-LT was associated with impaired periodontal health (p < 0.05). No difference between groups was found in the microbial counts. Salivary biomarker levels did not seem to be affected by diabetes. However, the advanced pro-inflammatory state induced by and associated with periodontal inflammation was reflected in the salivary biomarker levels, especially MMP-8 and the MMP-8/TIMP-1 molar ratio. Thus, these salivary biomarkers may be useful for monitoring the oral inflammatory state and the course of LT recipients.

scholarly journals Levels of Selected Matrix Metalloproteinases—MMP-1, MMP-2 and Fibronectin in the Saliva of Patients Planned for Endodontic Treatment or Surgical Extraction

2020 ◽  
Vol 9 (12) ◽  
pp. 3971
Author(s):  
Ewa Matuszczak ◽  
Izabela Cwalina ◽  
Marzena Tylicka ◽  
Katarzyna Wawrzyn ◽  
Magdalena Nowosielska ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Oral Cavity ◽  
Matrix Metalloproteinase ◽  
Dental Treatment ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Endodontic Treatment ◽  
Matrix Metalloproteinase 2 ◽  
Matrix Metalloproteinase 1 ◽  
Surgical Extraction

Objectives: Composition of saliva reflects the condition of the oral cavity. The aim of the study: Investigation of the concentrations of MMP-1 (Matrix metalloproteinase-1), MMP-2 (Matrix metalloproteinase-2) and fibronectin in the saliva of patients planned for endodontic treatment or surgical extraction. Material and methods: Seventy-five patients with caries and 14 healthy subjects were included in the study. Subjects were divided into group 1, in which 50 patients were planned for endodontic treatment, and group 2, in which 25 patients were planned for surgical extraction. For the measurements, we used a surface plasmon resonance imaging biosensor. Results: We found higher levels of MMP-1, MMP-2 and fibronectin in the saliva of patients planned for dental treatment than in healthy donors. We found lower concentrations of MMP-2 in subjects planned for surgical extraction, than in patients planned for endodontic treatment; however, there were no such differences in salivary concentrations of MMP-1 and fibronectin. There were no statistically significant differences in MMP-1 concentrations in the saliva before and after any type of dental treatment, but contrary to that, we found a statistically significant decrease in MMP-2 concentrations after endodontic treatment and after surgical extraction. We found a significant rise in the concentrations of fibronectin after surgical extraction but not after endodontic treatment. Conclusions: The concentrations of MMP-1 and MMP-2 in the saliva of our patients with caries were increased in comparison to healthy individuals, but after the treatment—so sanation of the oral cavity—we noted a decrease in matrix metalloproteinases (MMPs) levels. MMPs can be found in gingival crevicular fluid and saliva, carious dentin and plaque. According to our observations, the main source of MMPs in patients with caries is probably carious dentin. Increase in the salivary levels of fibronectin (FN) after surgical extraction may be connected with soft tissue injury caused by surgical extraction. Our results are another example of the fact that higher salivary concentrations of MMP-1, MMP-2 and FN can reflect the health status of the oral cavity in patients with caries.

scholarly journals Estimation of tissue inhibitor of matrix metalloproteinase-1 levels in gingival crevicular fluid in periodontal health, disease and after treatment

2014 ◽  
Vol 18 (3) ◽  
pp. 301 ◽  
Author(s):  
NagireddyRavindra Reddy ◽  
Anumala Deepa ◽  
DanduSubramanyam Madhu Babu ◽  
NelapatiSarath Chandra ◽  
ChowdawaramVenkat Subba Reddy ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Gingival Crevicular Fluid ◽  
Tissue Inhibitor ◽  
Periodontal Health ◽  
Matrix Metalloproteinase 1 ◽  
Crevicular Fluid

Matrix Metalloproteinase 1 as a Novel Biomarker for Monitoring Hepatocellular Carcinoma in Liver Transplant Patients

2018 ◽  
Vol 50 (2) ◽  
pp. 623-627 ◽  
Author(s):  
M.I. Sánchez-Lorencio ◽  
L. Saenz ◽  
P. Ramirez ◽  
F. Villalba-López ◽  
V. de la Orden ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Matrix Metalloproteinase ◽  
Liver Transplant ◽  
Transplant Patients ◽  
Matrix Metalloproteinase 1
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