scholarly journals Evidence of Tri-Exponential Decay for Liver Intravoxel Incoherent Motion MRI: A Review of Published Results and Limitations

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 379
Author(s):  
Olivier Chevallier ◽  
Yì Xiáng J. Wáng ◽  
Kévin Guillen ◽  
Julie Pellegrinelli ◽  
Jean-Pierre Cercueil ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Molecular Diffusion ◽  
Liver Tumors ◽  
Exponential Model ◽  
Intravoxel Incoherent Motion ◽  
Clinical Settings ◽  
Fast Diffusion ◽  
Applied Model ◽  
Published Evidence ◽  
Motion Mri

Diffusion weighted imaging (DWI) and intravoxel incoherent motion (IVIM) have been explored to assess liver tumors and diffused liver diseases. IVIM reflects the microscopic translational motions that occur in voxels in magnetic resonance (MR) DWI. In biologic tissues, molecular diffusion of water and microcirculation of blood in the capillary network can be assessed using IVIM DWI. The most commonly applied model to describe the DWI signal is a bi-exponential model, with a slow compartment of diffusion linked to pure molecular diffusion (represented by the coefficient Dslow), and a fast compartment of diffusion, related to microperfusion (represented by the coefficient Dfast). However, high variance in Dfast estimates has been consistently shown in literature for liver IVIM, restricting its application in clinical practice. This variation could be explained by the presence of another very fast compartment of diffusion in the liver. Therefore, a tri-exponential model would be more suitable to describe the DWI signal. This article reviews the published evidence of the existence of this additional very fast diffusion compartment and discusses the performance and limitations of the tri-exponential model for liver IVIM in current clinical settings.

Development of imaging biomarker for esophageal cancer using intravoxel incoherent motion MRI

Esophagus ◽  
2021 ◽  
Author(s):  
Ryoya Mizumachi ◽  
Koichi Hayano ◽  
Atsushi Hirata ◽  
Gaku Ohira ◽  
Shunsuke Imanishi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Intravoxel Incoherent Motion ◽  
Imaging Biomarker ◽  
Motion Mri

scholarly journals Intravoxel incoherent motion MRI for the initial characterization of non-fatty non-vascular soft tissue tumors

2020 ◽  
Vol 101 (4) ◽  
pp. 245-255 ◽  
Author(s):  
P.A. Gondim Teixeira ◽  
L. Simon ◽  
F. Sirveaux ◽  
B. Marie ◽  
M. Louis ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumors ◽  
Intravoxel Incoherent Motion ◽  
Initial Characterization ◽  
Motion Mri

scholarly journals Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease

2020 ◽  
Vol 51 (4) ◽  
Author(s):  
Sau May Wong ◽  
Walter H. Backes ◽  
Gerhard S. Drenthen ◽  
C. Eleana Zhang ◽  
Paulien H.M. Voorter ◽  
...  
Keyword(s):  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Spectral Diffusion ◽  
Small Vessel ◽  
Intravoxel Incoherent Motion ◽  
Vessel Disease ◽  
Diffusion Analysis ◽  
Motion Mri

scholarly journals Role of autophagy in the pathogenesis of liver diseases

2011 ◽  
Vol 152 (49) ◽  
pp. 1955-1961 ◽  
Author(s):  
Klára Werling
Keyword(s):  
Endoplasmic Reticulum ◽  
Liver Disease ◽  
Liver Diseases ◽  
Liver Tumors ◽  
Liver Steatosis ◽  
Prognostic Significance ◽  
Adenosine Monophosphate ◽  
Mutant Proteins ◽  
Alpha 1 Antitrypsin Deficiency

Autophagy is a self-digestion process that plays an important role in the development, differentiation and homeostasis of cells, helping their survival during starvation and hypoxia. Accumulated mutant proteins in the endoplasmic reticulum can be degraded by autophagy in alpha-1 antitrypsin deficiency. Hepatitis C and B virus may exploit the autophagy pathway to escape the innate immune response and to promote their own replication. Autophagy is decreased in response to chronic alcohol consumption, likely due to a decrease in 5’-adenosine monophosphate-activated protein kinase, increase in mTOR activity and due to an alteration in vesicle transport in hepatocytes. In obesity and alcoholic liver disease the decreased function of autophagy causes formation of Mallory-Denk bodies and cell death. The deficient autophagy can contribute to liver steatosis, to endoplasmic reticulum stress, and to progression of liver disease. Autophagy defect in hepatocellular carcinoma suggests that it can serve a tumor-suppressor function. The autophagy protein Beclin-1 levels have prognostic significance in liver tumors. Understanding of the molecular mechanism and the role of autophagy may lead to more effective therapeutic strategies in liver diseases in the future. Orv. Hetil., 2011, 152, 1955–1961.

Triggered intravoxel incoherent motion MRI for the assessment of calf muscle perfusion during isometric intermittent exercise

2018 ◽  
Vol 31 (6) ◽  
pp. e3922 ◽  
Author(s):  
Alfonso Mastropietro ◽  
Simone Porcelli ◽  
Marcello Cadioli ◽  
Letizia Rasica ◽  
Elisa Scalco ◽  
...  
Keyword(s):  
Intermittent Exercise ◽  
Calf Muscle ◽  
Intravoxel Incoherent Motion ◽  
Muscle Perfusion ◽  
Motion Mri

Intravoxel incoherent motion imaging has the possibility to detect liver abnormalities in young Fontan patients with good hemodynamics

2019 ◽  
Vol 29 (7) ◽  
pp. 898-903 ◽  
Author(s):  
Kazuhiro Shiraga ◽  
Kojiro Ono ◽  
Ryo Inuzuka ◽  
Hiroko Asakai ◽  
Takumi Ookubo ◽  
...  
Keyword(s):  
Laboratory Test ◽  
Molecular Diffusion ◽  
Normal Liver ◽  
Fontan Circulation ◽  
Intravoxel Incoherent Motion ◽  
Non Invasive ◽  
Imaging Parameters ◽  
The Right ◽  
Motion Imaging ◽  
Fontan Patients

AbstractIntroduction:Liver fibrosis and cirrhosis are one of the critical complications in Fontan patients. However, there are no well-established non-invasive and quantitative techniques for evaluating liver abnormalities in Fontan patients. Intravoxel incoherent motion diffusion-weighted imaging with MRI is a non-invasive and quantitative method to evaluate capillary network perfusion and molecular diffusion. The objective of this study is to assess the feasibility of intravoxel incoherent motion imaging in evaluating liver abnormalities in Fontan children.Materials and Methods:Five consecutive Fontan patients and four age-matched healthy volunteers were included. Fontan patients were 12.8 ± 1.5 years old at the time of MRI scan. Intravoxel incoherent motion imaging parameters (D, D*, and f values) within the right hepatic lobe were compared. Laboratory test, ultrasonography, and cardiac MRI were also conducted in the Fontan patients. Results of cardiac catheterization conducted within one year of the intravoxel incoherent motion imaging were also examined.Results:In Fontan patients, laboratory test and liver ultrasonography showed almost normal liver condition. Cardiac catheter and MRI showed good Fontan circulation. Cardiac index was 2.61 ± 0.23 L/min/m2. Intravoxel incoherent motion imaging parameters D, D*, and f values were lower in Fontan patients compared with controls (D: 1.1 ± 0.0 versus 1.3 ± 0.2 × 10−3 mm2/second (p = 0.04), D*: 30.8 ± 24.8 versus 113.2 ± 25.6 × 10−3 mm2/second (p < 0.01), and f: 13.2 ± 3.1 versus 22.4 ± 2.4% (p < 0.01), respectively).Conclusions:Intravoxel incoherent motion imaging is feasible for evaluating liver abnormalities in children with Fontan circulation.

scholarly journals Assessment of cerebral perfusion and edema in preeclampsia with intravoxel incoherent motion MRI

2018 ◽  
Vol 97 (10) ◽  
pp. 1212-1218 ◽  
Author(s):  
Maria Nelander ◽  
Daniel Hannsberger ◽  
Inger Sundström-Poromaa ◽  
Lina Bergman ◽  
Jan Weis ◽  
...  
Keyword(s):  
Cerebral Perfusion ◽  
Intravoxel Incoherent Motion ◽  
Motion Mri

scholarly journals The Value of Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging in the Evaluation of the Osteosarcoma Response to Preoperative Neoadjuvant Chemotherapy in Teens

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Houdong Zuo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diffusion Coefficient ◽  
Magnetic Resonance ◽  
Neoadjuvant Chemotherapy ◽  
Roc Curves ◽  
Intravoxel Incoherent Motion ◽  
Imaging Biomarkers ◽  
Fast Diffusion ◽  
Resonance Imaging ◽  
Before And After

Purpose. To investigate the value of intravoxel incoherent motion (IVIM) magnetic resonance imaging in the evaluation of the osteosarcoma (OS) response to preoperative neoadjuvant chemotherapy (NAC) in teens. Methods. Eighteen consecutive osteosarcoma patients (12 males and 6 females) diagnosed by histopathology were enrolled. All enrolled patients received NAC and underwent MRI examinations before and after 2 cycles of NAC. The volume (V), apparent diffusion coefficient (ADC), (slow) diffusion coefficient (D), pseudo-perfusion (fast) diffusion coefficient (D⁎or D star), and perfusion fractions (f) of the OS before and after NAC were measured and analysed. The sensitivity and the specificity of the ADC, D, D⁎ and f values and the correlation between changes in volume (ΔV) and the IVIM-derived parameters (ΔADC, ΔD, ΔD⁎ and Δf) were also calculated and analysed. Paired Student’s t-tests, receiver operating characteristic (ROC) curves, and Spearman correlation analyses were used. Results. The mean volume of the OS after NAC decreased significantly (61.55±9.3 cm3 vs 40.26±4.1 cm3) (P<0.05). After NAC, the ADC (1.21±0.09 × 10-3 mm2/s vs 1.73±0.11 × 10-3 mm2/s) and D (1.14±0.09 × 10-3 mm2/s vs 1.63±0.1 × 10-3 mm2/s) values increased and f (28.58±1.37% vs 20.93±1.16%) values decreased significantly (P<0.05), while D⁎ (9.17±0.98 × 10-3 mm2/s vs 8.94±0.13 × 10-3 mm2/s) values changed slightly (P>0.05). The AUC values of ADC (0.938) and D (0.943) were higher than those of D⁎ (0.574) and f (0.765). The sensitivity and specificity of ADC (0.778, 1) and D (0.944, 0.833) values were superior to those of D⁎ (0.278, 0.722) and f (0.5, 0.944) values. No significant correlations were found between the ΔV and ΔADC, ΔD, ΔD⁎ and Δf values (P>0.05). Conclusion. IVIM-derived parameters ADC and D have the potential to be imaging biomarkers for evaluation of the therapeutic response to NAC in OS patients.

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