scholarly journals Vascular Biomarkers: Physics Parameters and Circulating Molecules Can Be Two Faces of the Same Coin

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 217
Author(s):  
Paolo Zamboni
Keyword(s):  
Vascular Biomarkers

The arterial, venous and lymphatic conduits of human circulation are a fascinating field of research [...]

Paraoxonase-1 and myeloperoxidase correlate with vascular biomarkers in overweight patients with newly diagnosed untreated hyperlipidaemia

VASA ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 370-376 ◽  
Author(s):  
Anita Szentpéteri ◽  
Noémi Zsíros ◽  
Viktória E. Varga ◽  
Hajnalka Lőrincz ◽  
Mónika Katkó ◽  
...  
Keyword(s):  
Adhesion Molecule ◽  
Oxidized Ldl ◽  
Vascular Complications ◽  
Cd40 Ligand ◽  
Paraoxonase 1 ◽  
Intercellular Adhesion Molecule ◽  
Pon1 Activity ◽  
Intercellular Adhesion Molecule 1 ◽  
Inflammatory Parameters ◽  
Vascular Biomarkers

Abstract. Background: In hyperlipidaemic state, increased levels of myeloperoxidase (MPO) and decreased paraoxonase-1 (PON1) activity have been reported; however, their relationships with other atherosclerotic biomarkers have not been completely clarified. Patients and methods: Serum concentrations of lipid and inflammatory parameters, MPO levels, and PON1 activities were investigated in 167 untreated hyperlipidaemic patients with and without vascular complications and in 32 healthy controls. Additionally, levels of CD40 ligand (sCD40L) and asymmetric dimethyl arginine (ADMA), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1, and oxidized LDL were determined. Results: We found elevated C-reactive protein (CRP), ADMA, sCD40L, sICAM-1 concentrations, and higher MPO levels in patients with vascular complications compared to those without. The PON1 arylesterase activity correlated negatively with sCD40L, ADMA, and sICAM-1 levels, respectively. In contrast, MPO concentrations showed positive correlations with sCD40L, ADMA, and sICAM-1 levels, respectively. Conclusions: It can therefore be stated that PON1 activity and MPO level correlate strongly with the vascular biomarkers, highlighting the importance of the HDL-associated pro- and antioxidant enzymes in the development of endothelial dysfunction and atherogenesis.

Vascular Biomarkers in Asthma and COPD

2016 ◽  
Vol 16 (14) ◽  
pp. 1599-1609 ◽  
Author(s):  
Petros Bakakos ◽  
George Patentalakis ◽  
Alberto Papi
Keyword(s):  
Vascular Biomarkers

scholarly journals Vascular Biomarkers and Surrogates in Cardiovascular Disease

Circulation ◽  
2006 ◽  
Vol 113 (25) ◽  
pp. 2936-2942 ◽  
Author(s):  
Jean-Claude Tardif ◽  
Therese Heinonen ◽  
David Orloff ◽  
Peter Libby
Keyword(s):  
Cardiovascular Disease ◽  
Vascular Biomarkers

scholarly journals Automatic Segmentation and Measurement of Vascular Biomarkers in OCT-A Images

Proceedings ◽  
2018 ◽  
Vol 2 (18) ◽  
pp. 1169
Author(s):  
Macarena Díaz ◽  
Jorge Novo ◽  
Manuel G. Penedo ◽  
Marcos Ortega
Keyword(s):  
Correlation Coefficient ◽  
Automatic Segmentation ◽  
Clinical Analysis ◽  
Jaccard Index ◽  
Monitoring Process ◽  
Vascular Biomarkers

We propose an automatic methodology that identifies the vascularity zones in OCT-A images and their measurement for its use in clinical analysis and diagnostic processes. The segmentation and measurement contributes objectivity and repeatability in the results, desirable characteristics in any diagnosis and monitoring process. In the validation of the method, the correlation coefficient of Pearson and Jaccard index were used, obtaining satisfactory results.

New Proteins as Vascular Biomarkers in Primary Open Angle Glaucomatous Aqueous Humor

2012 ◽  
Vol 53 (7) ◽  
pp. 4242 ◽  
Author(s):  
Sergio Claudio Saccà ◽  
Marco Centofanti ◽  
Alberto Izzotti
Keyword(s):  
Aqueous Humor ◽  
Open Angle ◽  
Vascular Biomarkers

scholarly journals Vascular biomarkers in the metabolic syndrome

2009 ◽  
Vol 9 (3) ◽  
pp. 209-215 ◽  
Author(s):  
Njeri Thande ◽  
Robert S Rosenson
Keyword(s):  
Metabolic Syndrome ◽  
The Metabolic Syndrome ◽  
Vascular Biomarkers

scholarly journals Retinal vascular biomarkers for early detection and monitoring of Alzheimer’s disease

2013 ◽  
Vol 3 (2) ◽  
pp. e233-e233 ◽  
Author(s):  
S Frost ◽  
◽  
Y Kanagasingam ◽  
H Sohrabi ◽  
J Vignarajan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Detection ◽  
Vascular Biomarkers

scholarly journals Vascular calcification relationship to vascular biomarkers and bone metabolism in advanced chronic kidney disease

Bone ◽  
2021 ◽  
Vol 143 ◽  
pp. 115699
Author(s):  
Syazrah Salam ◽  
Orla Gallagher ◽  
Fatma Gossiel ◽  
Margaret Paggiosi ◽  
Richard Eastell ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Bone Metabolism ◽  
Vascular Calcification ◽  
Advanced Chronic Kidney Disease ◽  
Vascular Biomarkers

Vascular Inflammation, Calf Muscle Oxygen Saturation, and Blood Glucose are Associated With Exercise Pressor Response in Symptomatic Peripheral Artery Disease

Angiology ◽  
2019 ◽  
Vol 70 (8) ◽  
pp. 747-755 ◽  
Author(s):  
Andrew W. Gardner ◽  
Polly S. Montgomery ◽  
Ming Wang ◽  
Chixiang Chen ◽  
Marcos Kuroki ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Oxygen Saturation ◽  
Peripheral Artery Disease ◽  
Pressor Response ◽  
Calf Muscle ◽  
Peripheral Artery ◽  
Muscle Oxygen ◽  
Artery Disease ◽  
Vascular Biomarkers

We determined whether calf muscle oxygen saturation (StO2) and vascular biomarkers of inflammation and oxidative stress were associated with an exercise pressor response during treadmill walking in 179 patients with symptomatic peripheral artery disease (PAD). The exercise pressor response was measured as the change in blood pressure from rest to the end of the first 2-minute treadmill stage (2 mph, 0% grade). There was a wide range in the change in systolic blood pressure (−46 to 50 mm Hg) and in diastolic blood pressure (−23 to 38 mm Hg), with mean increases of 4.3 and 1.4 mm Hg, respectively. In multiple regression analyses, significant predictors of systolic pressure included glucose ( P < .001) and insulin ( P = .039). Significant predictors of diastolic pressure included cultured endothelial cell apoptosis ( P = .019), the percentage drop in exercise calf muscle (StO2; P = .023), high-sensitivity C-reactive protein ( P = .032), and glucose ( P = .033). Higher levels in pro-inflammatory vascular biomarkers, impaired calf muscle StO2 during exercise, and elevated blood glucose were independently associated with greater exercise pressor response in patients with symptomatic PAD. The clinical implication is that exercise and nutritional interventions designed to improve inflammation, microcirculation, and glucose metabolism may also lower blood pressure during exercise in patients with symptomatic PAD.

scholarly journals The Utility of Plasma Vascular Biomarkers in Systemic Sclerosis: A Prospective Longitudinal Analysis

2020 ◽  
Vol 72 (8) ◽  
pp. 1341-1349
Author(s):  
Christopher A. Mecoli ◽  
Ami A. Shah ◽  
Francesco Boin ◽  
Fredrick M. Wigley ◽  
Laura K. Hummers
Keyword(s):  
Systemic Sclerosis ◽  
Longitudinal Analysis ◽  
Vascular Biomarkers ◽  
Prospective Longitudinal
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