scholarly journals Altered Expression of Circadian Clock Genes in Patients with Atrial Fibrillation Is Associated with Atrial High-Rate Episodes and Left Atrial Remodeling

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 90
Author(s):  
Yung-Lung Chen ◽  
Jiin-Haur Chuang ◽  
Hui-Ting Wang ◽  
Huang-Chung Chen ◽  
Wen-Hao Liu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Circadian Clock ◽  
Left Atrial ◽  
Clock Genes ◽  
Circadian Variation ◽  
High Rate ◽  
Atrial Remodeling ◽  
Altered Expression ◽  
Expression Levels ◽  
Circadian Clock Genes

A prominent circadian variation is present in atrial fibrillation (AF) attacks that may be related to the expression of circadian clock genes. Little is known about the expression of circadian clock genes in AF. We prospectively enrolled 73 patients who had received pacemaker implantation, in order to define the burden of atrial high-rate episodes (AHREs) accurately. AF was diagnosed clinically in 43 (59%) patients (15 with persistent AF and 28 with paroxysmal AF). The expression levels of circadian clock genes of peripheral blood leukocytes were checked. There were more males and patients with a larger left atrial (LA) size and lower expression levels of BMAL1, CRY2, NR1D1, NR1D2, PER2, RORA, RORC, and TIM genes in persistent AF group than in other groups. There was a significant correlation between higher AHRE burden and larger LA size and between higher AHRE burden and decreased expression of circadian clock genes in patients with AF. LA volume and the expression of CRY1, NR1D1, and RORA are significantly associated with AHRE burden. However, the underlying mechanism needs to be elucidated in further studies.

scholarly journals Modulatory Effects of Circadian Rhythms in the Lung Adenocarcinoma Tumor Microenvironment

2021 ◽  
Author(s):  
Qianzhun Huang ◽  
Xiaoyang Su ◽  
Ning Fang ◽  
Jian Huang
Keyword(s):  
Tumor Microenvironment ◽  
Circadian Rhythms ◽  
Lung Adenocarcinoma ◽  
Circadian Clock ◽  
Drug Sensitivity ◽  
Molecular Mechanisms ◽  
Clock Genes ◽  
Functional Enrichment ◽  
Expression Levels ◽  
Circadian Clock Genes

Abstract Background: Dysregulated circadian dynamic balance is strongly associated with cancer development. However, biological functions of circadian rhythms in lung adenocarcinoma (LUAD) have not been elucidated. This study aimed at valuating the modulatory effects of circadian rhythms in the LUAD tumor microenvironment.Methods: Multiple open-source bioinformatics research platforms are used to comprehensively elucidate the expression level, prognosis, potential biological function, drug sensitivity, and immune microenvironment of circadian clock genes in LUAD.Results: Most circadian clock genes in LUAD are dysregulated and are strongly correlated with patient prognosis, and missense mutations at splicing sites of these genes. Besides, these genes are closely associated with some well-known cancer-related marker pathways, which are mainly involved in the inhibition of the Apoptosis, Cell cycle, and DNA Damage Response Pathway. Furthermore, functional enrichment analysis revealedthat circadian clock genes regulate transcription factor activities and circadian rhythms in LUAD tissues. As for drug sensitivity, high expression of CLOCK, CRY1, and NR1D2 as well as suppressedPER2 and CRY2 expression levels are associated with drug resistance. The expression levels of circadian clock genes in LUAD correlate with immune infiltration and are involved in the regulation of immunosuppression.Conclusions: Our multi-omics analysis provides a more comprehensive understanding of the molecular mechanisms of the circadian clock genes in LUAD and provides new insights for a more precise screening of prognostic biomarkers and immunotherapy.

scholarly journals Sleep Disturbance and Altered Expression of Circadian Clock Genes in Patients With Sudden Sensorineural Hearing Loss

Medicine ◽  
2015 ◽  
Vol 94 (26) ◽  
pp. e978 ◽  
Author(s):  
Chao-Hui Yang ◽  
Chung-Feng Hwang ◽  
Pai-Mei Lin ◽  
Jiin-Haur Chuang ◽  
Cheng-Ming Hsu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Circadian Clock ◽  
Sleep Disturbance ◽  
Sensorineural Hearing Loss ◽  
Clock Genes ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Altered Expression ◽  
Circadian Clock Genes

Altered expression of circadian clock genes in head and neck squamous cell carcinoma

Tumor Biology ◽  
2011 ◽  
Vol 33 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Cheng-Ming Hsu ◽  
Sheng-Fung Lin ◽  
Cheng-Tung Lu ◽  
Pei-Mei Lin ◽  
Ming-Yu Yang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Circadian Clock ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Clock Genes ◽  
Neck Squamous Cell Carcinoma ◽  
Altered Expression ◽  
Circadian Clock Genes

Altered expression of circadian clock genes in polyglandular autoimmune syndrome type III

Endocrine ◽  
2017 ◽  
Vol 59 (1) ◽  
pp. 109-119 ◽  
Author(s):  
Anna Angelousi ◽  
Narjes Nasiri-Ansari ◽  
Eliana Spilioti ◽  
Emilia Mantzou ◽  
Vasiliki Kalotyxou ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Clock Genes ◽  
Syndrome Type ◽  
Altered Expression ◽  
Polyglandular Autoimmune Syndrome ◽  
Type Iii ◽  
Autoimmune Syndrome ◽  
Circadian Clock Genes ◽  
Polyglandular Autoimmune Syndrome Type

Altered Expression of Circadian Clock Genes in Human Chronic Myeloid Leukemia

2011 ◽  
Vol 26 (2) ◽  
pp. 136-148 ◽  
Author(s):  
Ming-Yu Yang ◽  
Wen-Chi Yang ◽  
Pai-Mei Lin ◽  
Jui-Feng Hsu ◽  
Hui-Hua Hsiao ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Circadian Clock ◽  
Myeloid Leukemia ◽  
Clock Genes ◽  
Altered Expression ◽  
Circadian Clock Genes

scholarly journals Transcriptomal dissection of soybean circadian rhythmicity in two geographically, phenotypically and genetically distinct cultivars

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yanlei Yue ◽  
Ze Jiang ◽  
Enoch Sapey ◽  
Tingting Wu ◽  
Shi Sun ◽  
...  
Keyword(s):  
Gene Expression ◽  
Circadian Clock ◽  
Chromosome Structure ◽  
Clock Genes ◽  
Expression Profiles ◽  
Circadian Rhythmicity ◽  
Rna Seq ◽  
Night Time ◽  
Time Points ◽  
Circadian Clock Genes

Abstract Background In soybean, some circadian clock genes have been identified as loci for maturity traits. However, the effects of these genes on soybean circadian rhythmicity and their impacts on maturity are unclear. Results We used two geographically, phenotypically and genetically distinct cultivars, conventional juvenile Zhonghuang 24 (with functional J/GmELF3a, a homolog of the circadian clock indispensable component EARLY FLOWERING 3) and long juvenile Huaxia 3 (with dysfunctional j/Gmelf3a) to dissect the soybean circadian clock with time-series transcriptomal RNA-Seq analysis of unifoliate leaves on a day scale. The results showed that several known circadian clock components, including RVE1, GI, LUX and TOC1, phase differently in soybean than in Arabidopsis, demonstrating that the soybean circadian clock is obviously different from the canonical model in Arabidopsis. In contrast to the observation that ELF3 dysfunction results in clock arrhythmia in Arabidopsis, the circadian clock is conserved in soybean regardless of the functional status of J/GmELF3a. Soybean exhibits a circadian rhythmicity in both gene expression and alternative splicing. Genes can be grouped into six clusters, C1-C6, with different expression profiles. Many more genes are grouped into the night clusters (C4-C6) than in the day cluster (C2), showing that night is essential for gene expression and regulation. Moreover, soybean chromosomes are activated with a circadian rhythmicity, indicating that high-order chromosome structure might impact circadian rhythmicity. Interestingly, night time points were clustered in one group, while day time points were separated into two groups, morning and afternoon, demonstrating that morning and afternoon are representative of different environments for soybean growth and development. However, no genes were consistently differentially expressed over different time-points, indicating that it is necessary to perform a circadian rhythmicity analysis to more thoroughly dissect the function of a gene. Moreover, the analysis of the circadian rhythmicity of the GmFT family showed that GmELF3a might phase- and amplitude-modulate the GmFT family to regulate the juvenility and maturity traits of soybean. Conclusions These results and the resultant RNA-seq data should be helpful in understanding the soybean circadian clock and elucidating the connection between the circadian clock and soybean maturity.

Circadian clock genes as promising therapeutic targets for autoimmune diseases

2021 ◽  
pp. 102866
Author(s):  
Kun Xiang ◽  
Zhiwei Xu ◽  
Yu-Qian Hu ◽  
Yi-Sheng He ◽  
Guo-Cui Wu ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Circadian Clock ◽  
Clock Genes ◽  
Therapeutic Targets ◽  
Circadian Clock Genes
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