scholarly journals Platelet-Rich Plasma Ameliorates Cyclophosphamide-Induced Acute Interstitial Cystitis/Painful Bladder Syndrome in a Rat Model

Diagnostics ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 381
Author(s):  
Yung-Hsiang Chen ◽  
Kee-Ming Man ◽  
Wen-Chi Chen ◽  
Po-Len Liu ◽  
Kao-Sung Tsai ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Interstitial Cystitis ◽  
Platelet Rich Plasma ◽  
Virgin Female ◽  
Intravesical Instillation ◽  
Painful Bladder Syndrome ◽  
Female Rats ◽  
Cell Junction ◽  
Control Group ◽  
Painful Bladder

Background: Interstitial cystitis/painful bladder syndrome (IC/PBS) could be treated to ameliorate urothelial injury. Here, we investigated the efficacy of intravesical instillation with platelet-rich plasma (PRP) and hyaluronic acid for acute IC/PBS. Methods: The effects of PRP and hyaluronic acid on the proliferation of normal human fibroblast cells (HFCs) were assessed. Additionally, thirty virgin female rats were randomized into five groups: group 1, saline-injected control; group 2, cyclophosphamide (CYP) plus intravesical instillation with normal saline; group 3, CYP plus intravesical instillation with hyaluronic acid (1 mg/mL); group 4, CYP plus intravesical instillation with PRP; and group 5, CYP plus intravesical instillation with PRP plus hyaluronic acid. A cystometry and histological assessments were performed. The expression of cell junction-associated protein zonula occludens-2 (ZO-2) and inflammatory cytokine interleukin 6 (IL-6) was also measured. Results: Low dose PRP increased proliferation in HFCs. The acute IC/PBS rats showed significantly lower voiding interval values. Voiding interval values were significantly higher in the CYP plus intravesical instillation with PRP group than in the CYP-induced acute IC/PBS group. Additionally, the expression of ZO-2 was increased and IL-6 was decreased in the CYP plus intravesical instillation with PRP group compared with the CYP-induced acute IC/PBS group. Conclusion: These findings suggest that PRP modulate urothelial repair, which ameliorate the increase in urination frequency in rats treated with CYP. Overall, PRP may confer potential benefits by acting as urothelial repair modulators.

Intravesical hyaluronic acid and alkalinized lidocaine for the treatment of severe painful bladder syndrome/interstitial cystitis

2012 ◽  
Vol 23 (12) ◽  
pp. 1715-1720 ◽  
Author(s):  
Yi-Song Lv ◽  
Hui-Liang Zhou ◽  
Hou-Ping Mao ◽  
Rui Gao ◽  
Yan-Dong Wang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Interstitial Cystitis ◽  
Painful Bladder Syndrome ◽  
Painful Bladder

scholarly journals Systematic Review and Meta-Analysis of Intravesical Hyaluronic Acid and Hyaluronic Acid/Chondroitin Sulfate Instillation for Interstitial Cystitis/Painful Bladder Syndrome

2016 ◽  
Vol 39 (4) ◽  
pp. 1618-1625 ◽  
Author(s):  
Jung-Soo Pyo ◽  
Won Jin Cho
Keyword(s):  
Systematic Review ◽  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Interstitial Cystitis ◽  
Meta Analysis ◽  
Urine Volume ◽  
Painful Bladder Syndrome ◽  
Pain Symptom ◽  
Bladder Pain ◽  
Painful Bladder

Background/Aims: To assess the efficacy of intravesical hyaluronic acid (HA) and HA/chondroitin sulfate (CS) instillation in patients with interstitial cystitis/painful bladder syndrome by systematic review and meta-analysis. Methods: A systematic literature search was performed using the keywords: ‘interstitial cystitis' or ‘painful bladder syndrome' or ‘bladder pain syndrome' and ‘hyaluronic acid', up to March 31, 2016. The primary outcome was visual analogue scale related pain symptom (VAS). Secondary outcomes were the O'Leary-Sant Interstitial Cystitis Symptom Index (ICSI) and Problem Index (ICPI), frequency, nocturia, bladder volume, and voided urine volume. Results: Ten articles involving 390 patients were retrieved and assessed in analysis. A significant improvement in mean VAS on fixed-effect and random-effect models (mean difference [MD] -3.654, 95% confidence interval [CI] -3.814 to -3.495, and MD -3.206, 95% CI -4.156 to -2.257, respectively) was found. Significant improvements were found in the ICSI (MD -3.223, 95% CI -4.132 to -2.315) and ICPI (MD -2.941, 95% CI -3.767 to -2.116). Similarly, the other outcomes were significantly improved. Conclusion: Intravesical HA and HA/CS instillation improved pain symptom, quality of life, and other outcomes and could be included as therapeutic modality of interstitial cystitis/painful bladder syndrome.

scholarly journals The diagnostic value of nerve growth factor and c-reactive protein in patients with interstitial cystitis / painful bladder syndrome

2020 ◽  
Vol 10 (1) ◽  
pp. 61-66
Author(s):  
Rashad F. Sholan
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Interstitial Cystitis ◽  
Diagnostic Value ◽  
Painful Bladder Syndrome ◽  
Control Group ◽  
C Reactive Protein ◽  
Nerve Growth ◽  
Reactive Protein ◽  
Painful Bladder

Objective: to determine the diagnostic value of nerve growth factor (NGF) and C-reactive protein (CRP) in patients with interstitial cystitis / painful bladder syndrome (IC/BPS). Material and methods. 44 patients with IC/BPS (main group) and 20 volunteers (control group) were examined. The average age of the patients of the main group was 46.4 13.9 years, the control group 35.3 9.7 years. Cystoscopy and hydrodistension of the bladder were performed. The severity of pain was evaluated on a visual analogue scale (VAS). The concentration of NGF was determined in the blood by the method of ELISA, CRP by the immunoturbidimetric method. Results. The average total score on the VAS scale was 5.47 0.91, mild pain (24 points) was noted by 20.4%, moderate pain (56 points) 54.5%, severe pain (78 points) 25.0% of patients. Diffuse bleeding of the bladder mucosa in 45.4% of cases was observed. In IC/BPS patients the average NGF level was 11.23 8.22 ng/ml, CRP 3.56 1.66 mg/l. The concentration of NGF exceeded the control level by 22.7% (p 0.05), CRP by 71.3% (p = 0.015). The correlation coefficient of NGF with CRP was r = + 0.179 (p = 0.42), and the determination coefficient was R2 = 0.032. Conclusion. Identified statistically significantly increased levels of NGF and CRP in the blood serum of IC/BPS patients confirm the presence of a systemic inflammatory reaction. A weak direct correlation is determined between NGF and CRP in patients with IC/BPS patients. The determination of serum NGF and CRP in combination with clinical data can be used to diagnose IC/ BPS.

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