scholarly journals Magnetic Resonance Imaging and Modeling of the Glymphatic System

Diagnostics ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 344 ◽  
Author(s):  
Jasleen Kaur ◽  
Esmaeil Davoodi-Bojd ◽  
Lara M Fahmy ◽  
Li Zhang ◽  
Guangliang Ding ◽  
...  

The glymphatic system is a newly discovered waste drainage pathway in the brain; it plays an important role in many neurological diseases. Ongoing research utilizing various cerebrospinal fluid tracer infusions, either directly or indirectly into the brain parenchyma, is investigating clearance pathways by using distinct imaging techniques. In the present review, we discuss the role of the glymphatic system in various neurological diseases and efflux pathways of brain waste clearance based on current evidence and controversies. We mainly focus on new magnetic resonance imaging (MRI) modeling techniques, along with traditional computational modeling, for a better understanding of the glymphatic system function. Future sophisticated modeling techniques hold the potential to generate quantitative maps for glymphatic system parameters that could contribute to the diagnosis, monitoring, and prognosis of neurological diseases. The non-invasive nature of MRI may provide a safe and effective way to translate glymphatic system measurements from bench-to-bedside.

Author(s):  
Hamed Samadi Ghoushchi ◽  
Yaghoub Pourasad

<p>The purpose of this article is to investigate techniques for classifying tumor grade from magnetic resonance imaging (MRI). This requires early diagnosis of the brain tumor and its grade. Magnetic resonance imaging may show a clear tumor in the brain, but doctors need to measure the tumor in order to treat more or to advance treatment. For this purpose, digital imaging techniques along with machine learning can help to quickly identify tumors and also treatments and types of surgery. These combined techniques in understanding medical images for researchers are an important tool to increase the accuracy of diagnosis. In this paper, classification methods for MRI images of tumors of the human brain are performed to review the astrocytoma-containing glands. Methods used to classify brain tumors, including preprocessing, screening, tissue extraction, and statistical features of the tumor using two types of T<sub>1</sub>W and Flair brain MRI images and also the method of dimensionality reduction of extracted features and how to train them in classification are also explained. Determine the tumor area using three classification of Fuzzy Logic <em>C</em><em>-</em><em>Means</em><em> </em>Clustering (FCM), Probabilistic Neural Networks (PNN) and Support Vector Machines (SVM). In this paper, simulated and real MRI images are used. The results obtained from the proposed methods in this paper are compared with the reference results and the results show that the proposed approach can increase the reliability of brain tumor diagnosis.</p>


2020 ◽  
pp. 5802-5817
Author(s):  
Andrew J. Molyneux ◽  
Shelley Renowden ◽  
Marcus Bradley

The modern imaging techniques of computed tomography and magnetic resonance imaging for the demonstration of structural neurological disease have developed rapidly since their first introduction in the 1970s and 1980s, respectively. They have undergone further technological evolution, particularly in the last 10 years, and continue to do so. A variety of both computed tomography- and magnetic resonance imaging-based techniques can provide anatomical, angiographic, and functional information. In addition, biochemical data may be obtained using magnetic resonance spectroscopy and microstructural information can be obtained using diffusion tensor imaging. The choice between computed tomography or magnetic resonance imaging depends on several factors. This chapter explains the various applications of both techniques and the situations that can call for either, or both.


2018 ◽  
Vol 22 (1) ◽  
pp. 17-45 ◽  
Author(s):  
Leyla Loued-Khenissi ◽  
Olivia Döll ◽  
Kerstin Preuschoff

Functional magnetic resonance imaging is a galvanizing tool for behavioral scientists. It provides a means by which to see what the brain does while a person thinks, acts, or perceives, without invasive procedures. In this, fMRI affords us a relatively easy manner by which to peek under the hood of behavior and into the brain. Characterizing behavior with a neural correlate allows us to support or discard theoretical assumptions about the brain and behavior, to identify markers for individual and group differences. The increasing popularity of fMRI is facilitated by the apparent ease of data acquisition and analysis. This comes at a price: low signal-to-noise ratios, limitations in experimental design, and the difficulty in correctly applying and interpreting statistical tests are just a few of the pitfalls that have brought into question the reliability and validity of published fMRI data. Here, we aim to provide a general overview of the method, with an emphasis on fMRI and its analysis. Our goal is to provide the novice user with a comprehensive framework to get started on designing an imaging experiment in humans.


2020 ◽  
pp. 096228022095387
Author(s):  
Rakhi Singh ◽  
John Stufken

To study brain activity, by measuring changes associated with the blood flow in the brain, functional magnetic resonance imaging techniques are employed. The design problem in event-related functional magnetic resonance imaging studies is to find the best sequence of stimuli to be shown to subjects for precise estimation of the brain activity. Previous analytical studies concerning optimal functional magnetic resonance imaging designs often assume a simplified model with independent errors over time. Optimal designs under this model are called g-lag orthogonal designs. Recently, it has been observed that g-lag orthogonal designs also perform well under simplified models with auto-regressive error structures. However, these models do not include drift. We investigate the performance of g-lag orthogonal designs for models that incorporate drift parameters. Identifying g-lag orthogonal designs that perform best in the presence of a drift is important because a drift is typically assumed for the analysis of event-related functional magnetic resonance imaging data.


2018 ◽  
Vol 7 (3) ◽  
pp. 217-221
Author(s):  
E. V. Shevchenko ◽  
G. R. Ramazanov ◽  
S. S. Petrikov

Background Acute dizziness may be the only symptom of stroke. Prevalence of this disease among patients with isolated dizziness differs significantly and depends on study design, inclusion criteria and diagnostic methods. In available investigations, we did not find any prospective studies where magnetic resonance imaging, positional maneuvers, and Halmagyi-Curthoys test had been used to clarify a pattern of diseases with isolated acute dizziness and suspected stroke.Aim of study To clarify the pattern of the causes of dizziness in patients with suspected acute stroke.Material and methods We examined 160 patients admitted to N.V. Sklifosovsky Research Institute for Emergency Medicine with suspected stroke and single or underlying complaint of dizziness. All patients were examined with assessment of neurological status, Dix-Hollpike and Pagnini-McClure maneuvers, HalmagyiCurthoys test, triplex scans of brachiocephalic arteries, transthoracic echocardiography, computed tomography (CT) and magnetic resonance imaging (MRI) of the brain with magnetic field strength 1.5 T. MRI of the brain was performed in patients without evidence of stroke by CT and in patients with stroke of undetermined etiology according to the TOAST classification.Results In 16 patients (10%), the cause of dizziness was a disease of the brain: ischemic stroke (n=14 (88%)), hemorrhage (n=1 (6%)), transient ischemic attack (TIA) of posterior circulation (n=1 (6%)). In 70.6% patients (n=113), the dizziness was associated with peripheral vestibulopathy: benign paroxysmal positional vertigo (n=85 (75%)), vestibular neuritis (n=19 (17%)), Meniere’s disease (n=7 (6%)), labyrinthitis (n=2 (1,3%)). In 6.9% patients (n=11), the cause of dizziness was hypertensive encephalopathy, 1.9% of patients (n=3) had heart rhythm disturbance, 9.4% of patients (n=15) had psychogenic dizziness, 0.6% of patients (n=1) had demyelinating disease, and 0.6% of patients (n=1) had hemic hypoxia associated with iron deficiency anemia.Conclusion In 70.6% patients with acute dizziness, admitted to hospital with a suspected stroke, peripheral vestibulopathy was revealed. Only 10% of patients had a stroke as a cause of dizziness.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sang Wha Kim ◽  
Adams Hei Long Yuen ◽  
Cherry Tsz Ching Poon ◽  
Joon Oh Hwang ◽  
Chang Jun Lee ◽  
...  

AbstractDue to their important phylogenetic position among extant vertebrates, sharks are an invaluable group in evolutionary developmental biology studies. A thorough understanding of shark anatomy is essential to facilitate these studies and documentation of this iconic taxon. With the increasing availability of cross-sectional imaging techniques, the complicated anatomy of both cartilaginous and soft tissues can be analyzed non-invasively, quickly, and accurately. The aim of this study is to provide a detailed anatomical description of the normal banded houndshark (Triakis scyllium) using computed tomography (CT) and magnetic resonance imaging (MRI) along with cryosection images. Three banded houndsharks were scanned using a 64-detector row spiral CT scanner and a 3 T MRI scanner. All images were digitally stored and assessed using open-source Digital Imaging and Communications in Medicine viewer software in the transverse, sagittal, and dorsal dimensions. The banded houndshark cadavers were then cryosectioned at approximately 1-cm intervals. Corresponding transverse cryosection images were chosen to identify the best anatomical correlations for transverse CT and MRI images. The resulting images provided excellent detail of the major anatomical structures of the banded houndshark. The illustrations in the present study could be considered as a useful reference for interpretation of normal and pathological imaging studies of sharks.


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