scholarly journals Viscoelastic Biomarkers of Ex Vivo Liver Samples via Torsional Wave Elastography

Diagnostics ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 111 ◽  
Author(s):  
Inas H. Faris ◽  
Juan Melchor ◽  
Antonio Callejas ◽  
Jorge Torres ◽  
Guillermo Rus

The clinical ultrasound community demands mechanisms to obtain the viscoelastic biomarkers of soft tissue in order to quantify the tissue condition and to be able to track its consistency. Torsional Wave Elastography (TWE) is an emerging technique proposed for interrogating soft tissue mechanical viscoelastic constants. Torsional waves are a particular configuration of shear waves, which propagate asymmetrically in-depth and are radially transmitted by a disc and received by a ring. This configuration is shown to be particularly efficient in minimizing spurious p-waves components and is sensitive to mechanical constants, especially in cylinder-shaped organs. The objective of this work was to validate (TWE) technique against Shear Wave Elasticity Imaging (SWEI) technique through the determination of shear wave velocity, shear moduli, and viscosity of ex vivo chicken liver samples and tissue mimicking hydrogel phantoms. The results of shear moduli for ex vivo liver tissue vary 1.69–4.0kPa using TWE technique and 1.32–4.48kPa using SWEI technique for a range of frequencies from 200 to 800Hz. Kelvin–Voigt viscoelastic parameters reported values of μ = 1.51kPa and η = 0.54Pa·s using TWE and μ = 1.02kPa and η = 0.63Pa·s using SWEI. Preliminary results show that the proposed technique successfully allows reconstructing shear wave velocity, shear moduli, and viscosity mechanical biomarkers from the propagated torsional wave, establishing a proof of principle and warranting further studies.

2016 ◽  
Vol 45 (11) ◽  
pp. 1541-1551 ◽  
Author(s):  
Andrea B. Rosskopf ◽  
Elias Bachmann ◽  
Jess G. Snedeker ◽  
Christian W. A. Pfirrmann ◽  
Florian M. Buck

Geophysics ◽  
2009 ◽  
Vol 74 (3) ◽  
pp. E135-E147 ◽  
Author(s):  
Gregor T. Baechle ◽  
Gregor P. Eberli ◽  
Ralf J. Weger ◽  
Jose Luis Massaferro

To assess saturation effects on acoustic properties in carbonates, we measure ultrasonic velocity on 38 limestone samples whose porosity ranges from 5% to 30% under dry and water-saturated conditions. Complete saturation of the pore space with water causes an increase and decrease in compressional- and shear-wave velocity as well as significant changes in the shear moduli. Compressional velocities of most water-saturated samples are up to [Formula: see text] higher than the velocities of the dry samples. Some show no change, and a few even show a decrease in velocity. Shear-wave velocity [Formula: see text] generally decreases, but nine samples show an increase of up to [Formula: see text]. Water saturation decreases the shear modulus by up to [Formula: see text] in some samples and increases it by up to [Formula: see text] in others. The average increase in the shear modulus with water saturation is [Formula: see text]; the average decrease is [Formula: see text]. The [Formula: see text] ratio shows an overall increase with water saturation. In particular, rocks displaying shear weakening have distinctly higher [Formula: see text] ratios. Grainstone samples with high amounts of microporosity and interparticle macro-pores preferentially show shear weakening, whereas recrystallized limestones are prone to increase shear strengths with water saturation. The observed shear weakening indicates that a rock-fluid interaction occurs with water saturation, which violates one of the assumptions in Gassmann’s theory. We find a positive correlation between changes in shear modulus and the inability of Gassmann’s theory to predict velocities of water-saturated samples at high frequencies. Velocities of water-saturated samples predicted by Gassmann’s equation often exceed measured values by as much as [Formula: see text] for samples exhibiting shear weakening. In samples showing shear strengthening, Gassmann-predicted velocity values are as much as [Formula: see text] lower than measured values. In 66% of samples, Gassmann-predicted velocities show a misfit to measured water-saturated P-wave velocities. This discrepancy between measured and Gassmann-predicted velocity is not caused solely by velocity dispersion but also by rock-fluid interaction related to the pore structure of carbonates. Thus, a pore analysis should be conducted to assess shear-moduli changes and the resultant uncertainty for amplitude variation with offset analyses and velocity prediction using Gassmann’s theory.


2020 ◽  
Vol 26 (13-14) ◽  
pp. 720-732
Author(s):  
Emma S. Gargus ◽  
Kristen L. Jakubowski ◽  
Gabriel A. Arenas ◽  
Scott J. Miller ◽  
Sabrina S. M. Lee ◽  
...  

2020 ◽  
Vol 59 (SK) ◽  
pp. SKKB05
Author(s):  
Leslie Bustamante ◽  
Masaya Saeki ◽  
Takashi Misaki ◽  
Mami Matsukawa

Solid Earth ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 379-390 ◽  
Author(s):  
Yaniv Darvasi ◽  
Amotz Agnon

Abstract. Instrumental strong motion data are not common around the Dead Sea region. Therefore, calibrating a new attenuation equation is a considerable challenge. However, the Holy Land has a remarkable historical archive, attesting to numerous regional and local earthquakes. Combining the historical record with new seismic measurements will improve the regional equation. On 11 July 1927, a rupture, in the crust in proximity to the northern Dead Sea, generated a moderate 6.2 ML earthquake. Up to 500 people were killed, and extensive destruction was recorded, even as far as 150 km from the focus. We consider local near-surface properties, in particular, the shear-wave velocity, as an amplification factor. Where the shear-wave velocity is low, the seismic intensity far from the focus would likely be greater than expected from a standard attenuation curve. In this work, we used the multichannel analysis of surface waves (MASW) method to estimate seismic wave velocity at anomalous sites in Israel in order to calibrate a new attenuation equation for the Dead Sea region. Our new attenuation equation contains a term which quantifies only lithological effects, while factors such as building quality, foundation depth, topography, earthquake directivity, type of fault, etc. remain out of our scope. Nonetheless, about 60 % of the measured anomalous sites fit expectations; therefore, this new ground-motion prediction equation (GMPE) is statistically better than the old ones. From our local point of view, this is the first time that integration of the 1927 historical data and modern shear-wave velocity profile measurements improved the attenuation equation (sometimes referred to as the attenuation relation) for the Dead Sea region. In the wider context, regions of low-to-moderate seismicity should use macroseismic earthquake data, together with modern measurements, in order to better estimate the peak ground acceleration or the seismic intensities to be caused by future earthquakes. This integration will conceivably lead to a better mitigation of damage from future earthquakes and should improve maps of seismic hazard.


2021 ◽  
pp. 875529302110010
Author(s):  
Sameer Ladak ◽  
Sheri Molnar ◽  
Samantha Palmer

Site characterization is a crucial component in assessing seismic hazard, typically involving in situ shear-wave velocity ( VS) depth profiling, and measurement of site amplification including site period. Noninvasive methods are ideal for soil sites and become challenging in terms of field logistics and interpretation in more complex geologic settings including rock sites. Multiple noninvasive active- and passive-seismic techniques are applied at 25 seismograph stations across Eastern Canada. It is typically assumed that these stations are installed on hard rock. We investigate which site characterization methods are suitable at rock sites as well as confirm the hard rock assumption by providing VS profiles. Active-source compression-wave refraction and surface wave array techniques consistently provide velocity measurements at rock sites; passive-source array testing is less consistent but it is our most suitable method in constraining the rock VS. Bayesian inversion of Rayleigh wave dispersion curves provides quantitative uncertainty in the rock VS. We succeed in estimating rock VS at 16 stations, with constrained rock VS estimates at 7 stations that are consistent with previous estimates for Precambrian and Paleozoic rock types. The National Building Code of Canada uses solely the time-averaged shear-wave velocity of the upper 30 m ( VS30) to classify rock sites. We determine a mean VS30 of ∼ 1600 m/s for 16 Eastern Canada stations; the hard rock assumption is correct (>1500 m/s) but not as hard as often assumed (∼2000 m/s). Mean variability in VS30 is ∼400 m/s and can lead to softer rock classifications, in particular, for Paleozoic rock types with lower average rock VS near the hard/soft rock boundary. Microtremor and earthquake horizontal-to-vertical spectral ratios are obtained and provide site period classifications as an alternative to VS30.


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