scholarly journals Anaplastic Thyroid Carcinoma Histologically Mimicking a Plasmacytoma

Diagnostics ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 29
Author(s):  
Joshua H. Mo ◽  
Donald Tan ◽  
Xiaohui S. Zhao ◽  
Tjoson Tjoa ◽  
Beverly Y. Wang
Keyword(s):  
Thyroid Carcinoma ◽  
Plasma Cells ◽  
Correct Diagnosis ◽  
Anaplastic Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Unique Case ◽  
Histological Features ◽  
Cellular Origin ◽  
Rare Malignancy ◽  
Undifferentiated Thyroid Carcinoma

Anaplastic (undifferentiated) thyroid carcinoma (ATC) is a rare malignancy which may arise from transformation of a pre-existing differentiated carcinoma. We report the unique case where a lesion of thyroid origin presented with the histological features of mature plasma cells. Immunohistochemistry confirmed the lesion to be an anaplastic thyroid carcinoma arising from papillary thyroid carcinoma. A tumor mimicking a malignancy of a different cellular origin can lead clinicians to incorrect treatment approaches. Careful correlation with clinical details and knowledge of these unique presentations is important for reaching the correct diagnosis.

Spindle Cell Transformation of Papillary Carcinoma

2004 ◽  
Vol 128 (1) ◽  
pp. 87-89 ◽  
Author(s):  
Margaret S. Brandwein-Gensler ◽  
Beverly Y. Wang ◽  
Mark L. Urken
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Spindle Cell ◽  
Cell Transformation ◽  
Anaplastic Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Unique Case ◽  
Spindle Cells ◽  
De Quervain ◽  
Malignant Diagnosis

Abstract Spindle cells are not routinely encountered in the context of thyroid pathology and are most often present in anaplastic thyroid carcinoma, medullary thyroid carcinoma, and benign conditions such as Riedel struma or de Quervain granulomatous thyroiditis. Only a few publications have reported papillary thyroid carcinoma admixed with a prominent spindle cell component. While these tumors are clearly distinct from anaplastic thyroid carcinoma, prognostication as to their oncologic potential is not yet established. We describe a unique case of spindle cell transformation of papillary thyroid carcinoma. The blandness of the spindle cells was so impressive as to dissuade us from a malignant diagnosis on preoperative biopsies. However, this patient unfortunately died shortly after transformation of this papillary thyroid carcinoma. We conclude that this peculiar and rare spindle cell transformation should be regarded as a potentially lethal variant of papillary thyroid carcinoma.

The coexistence of anaplastic thyroid carcinoma and papillary thyroid carcinoma: two case reports

2014 ◽  
Author(s):  
Husniye Baser ◽  
Mina Gulfem Kaya ◽  
Sefika Burcak Polat ◽  
Ersin Gurkan Dumlu ◽  
Canan Altunkaya ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Case Reports ◽  
Anaplastic Thyroid Carcinoma ◽  
Papillary Thyroid

Follicular thyroid carcinoma and follicular variant papillary thyroid carcinoma: Clinical and histological features depending on the initial size

2017 ◽  
Author(s):  
Fernando Garcia Perez ◽  
Guillermo Martinez de Pinillos Gordillo ◽  
Mariana Tome Fernandez-Ladreda ◽  
Eyvee Arturo Cuellar Lloclla ◽  
Jose Alvaro Romero Porcel ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Initial Size ◽  
Histological Features

scholarly journals Cytohistological Concordance of Papillary Carcinoma of Thyroid and Its Variants

2021 ◽  
Vol 8 (04) ◽  
pp. 213-218
Author(s):  
Nameera Saleem ◽  
Naval Kishore Bajaj ◽  
Ezhil Arasi Nagamuthu
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Carcinoma ◽  
Fine Needle Aspiration ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Fine Needle ◽  
Nuclear Features

BACKGROUND Papillary thyroid carcinoma is the most common malignancy of the thyroid gland. Fine Needle Aspiration Cytology (FNAC) is a rapid, safe and economic procedure, and has a sensitivity approaching of 93.5 % and specificity close to 90 % for diagnosing papillary thyroid carcinomas. This study aims at correlating the cytological and histological diagnosis to arrive at the rate of concordance and discordance, identify variants of papillary thyroid carcinoma (PTC) on cytology and discuss the cytological mimics of PTC. METHODS Data from cases was collected over a period of three years (2015 - 2018). A descriptive study was done. Cases from Osmania General Hospital representing histologically proven cases of papillary carcinoma thyroid along with their corresponding cytological findings were analysed. Cytosmears were obtained from fine needle aspiration of thyroid lesions using a 26-gauge needle, stained with haematoxylin and eosin (H&E). Thyroidectomy specimens were fixed in 10 % buffered formalin, grossed and paraffin embedded. After processing, sections obtained by microtomy were stained with H & E for histopathologic evaluation. RESULTS The institute received a total of 258 thyroid specimens for histopathology and 686 cases for thyroid FNAC over a period of three years. This study includes 70 cases which had both cytology and histopathology correlation at our institution. 65 cases were diagnosed as PTC on histopathology and correct diagnosis was made on cytology with 73.8 % concordance (48 / 65 cases) and discordance was seen in 26.1 % (17 / 65 cases). 5 cases were misdiagnosed on cytology as PTC, and on histopathological examination were diagnosed as non-PTC. CONCLUSIONS Fine needle aspiration shows variable accuracy for PTC, ranging from 65 % to 90 %. The architectural arrangement of cells in papillary fragments and presence of nuclear features in majority of cells is diagnostic of the conventional variant of PTC. The other variants however, pose a diagnostic dilemma on account of their architectural variation, altered cytomorphology and the scant presence of nuclear features. An increase in the awareness of cytomorphology of variants and also of the mimics of PTC helps improve the diagnostic accuracy on FNAC. KEYWORDS Papillary Thyroid Carcinoma, Variants of PTC, Cytohistopathological Correlation

Parapharyngeal metastasis from papillary thyroid carcinoma: a case diagnosed by thyroglobulin measurement in peroral fine-needle aspiration of a cystic metastatic lymph node

2005 ◽  
Vol 119 (2) ◽  
pp. 155-157 ◽  
Author(s):  
Chisato Tomoda ◽  
Fumio Matsuzuka ◽  
Akira Miyauchi
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Metastatic Lymph Node ◽  
Correct Diagnosis ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Fine Needle ◽  
Metastatic Lymph

We report a case of a parapharyngeal cystic metastatic lymph node arising from papillary thyroid carcinoma (PTC). Parapharyngeal metastases arising from PTC are rare and correct diagnosis of the parapharyngeal mass before surgery is difficult. In this case, the diagnosis of a parapharyngeal mass was made pre-operatively by thyroglobulin measurement in peroral fine-needle aspiration with negative cytology.

Metastasis of follicular variant of papillary thyroid carcinoma masquerading as primary temporal bone tumour

2011 ◽  
Vol 125 (5) ◽  
pp. 528-532 ◽  
Author(s):  
S C Hugh ◽  
D Enepekides ◽  
J Wong ◽  
R Yeung ◽  
V Y W Lin
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Bone Mass ◽  
Temporal Bone ◽  
Treatment Plan ◽  
Correct Diagnosis ◽  
Bone Tumour ◽  
Final Diagnosis ◽  
Papillary Thyroid ◽  
Follicular Variant

AbstractObjective:We describe the first published case of papillary thyroid carcinoma metastatic to the temporal bone.Case report:A 64-year-old woman presented with a large left temporal bone mass centred in the jugular foramen, initially thought to be a paraganglioma or schwannoma. She was simultaneously being investigated for a left-sided thyroid nodule, which was found to be unremarkable on repeated fine needle aspiration cytology. A biopsy of the temporal bone mass indicated that it was of thyroid origin. The patient underwent total thyroidectomy, which enabled a final diagnosis of follicular-variant papillary thyroid carcinoma with metastasis to the temporal bone.Conclusion:Although biopsy is not the usual management for many types of temporal bone mass, pathological investigation is recommended if the tumour has an atypical growth rate, location, spread and/or radiological features. Metastasis of papillary thyroid carcinoma to the skull base is extremely rare, and correct diagnosis is essential in order to pursue an effective treatment plan.

scholarly journals Undifferentiated Thyroid Carcinoma With Anaplastic Features in a 78-Year-Old Filipino Female: A Case Report

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A903-A904
Author(s):  
Marion Bagaloyos Sarigumba ◽  
Maria Jocelyn Capuli Isidro
Keyword(s):  
Thyroid Carcinoma ◽  
Frozen Section ◽  
Care Center ◽  
Tertiary Care ◽  
Anaplastic Thyroid Carcinoma ◽  
Thyroid Function Tests ◽  
Respiratory Compromise ◽  
Spindle Cell Neoplasm ◽  
Coronary Syndrome ◽  
Undifferentiated Thyroid Carcinoma

Abstract Background: Anaplastic thyroid carcinoma (ATC) accounts for 0.8-9.8% of all thyroid cancers globally with a median survival from diagnosis of 5 months. Clinical Case: A 78-year-old Filipino female sought consult due to a rapidly progressive anterior neck mass. This started as a centimeter-sized nodule initially noted three months prior. Two months after, there was gradual enlargement to a fist-size, movable mass, hard in consistency associated with dysphagia and hoarseness of voice. On consult, neck ultrasound revealed an enlarged right thyroid with a mass in the right lobe (TI-RADS 5), multinodular with no lymphadenopathy. Furthermore, a CT scan of the neck was done to evaluate for other structural causes of dysphagia showing no intrathoracic extension. Patient was advised surgery but was lost to follow up due to lockdown from COVID-19. In the interim, patient was admitted for aspiration pneumonia. IV antibiotics were initiated and urgent surgery was advised to relieve patient of respiratory compromise. Patient was airlifted to a tertiary care center for further management. Baseline thyroid function tests were normal. Repeat neck imaging showed interval increase in the hypodense mass measuring 6x9x8 cm (from 3x4x5 cm) (APxWxCC) extending to the hypopharynx and laryngeal vestibule with mass effect to the trachea and esophagus. A multidisciplinary meeting was done to establish goals of care. On the 3rd hospital day, a tracheostomy with incisional biopsy and frozen section was done which revealed round to spindle cell neoplasm with anaplastic features. No further surgical resection was done and specimen was sent for immunohistochemical staining. Long term enteral access was secured during the same operation. Final histopathology showed undifferentiated thyroid carcinoma with anaplastic features and no definite lymphovascular invasion. Immunohistochemical markers were negative for CD3, CD20, Thyroglobulin, TTF-1, PAX8, Calcitonin and Pancytokeratin which reveal loss of tumor antigenicity, consistent with the histopathologic diagnosis. Metastatic work-up revealed varisized pulmonary, subpleural and hepatic nodules with lymphangitic carcinomatosis. Patient was staged as IVC (T4N1M1). Patient was referred for radiation to maximize local control, to complete 33 fractions of 200 cGy on the thyroid mass and received one cycle of Paclitaxel before discharge. Concurrent chemoradiation was continued and completed 29 cycles of radiation and 2 cycles of Paclitaxel which significantly reduced the tumor size. However, the patient succumbed to acute coronary syndrome on her third admission. Conclusion: There is currently no consensus first-line treatment modality available worldwide. Although the diagnosis and treatment of ATC is considered medically urgent, end-of-life planning must be given high priority in order to optimize the quality of the patient’s remaining life.

scholarly journals A rare case of collision tumor of thyroid gland: simultaneous occurrence of calcitonin negative medullary thyroid carcinoma and papillary thyroid carcinoma

2019 ◽  
Vol 5 (6) ◽  
pp. 1726
Author(s):  
Savita Saharan ◽  
Ranjana Solanki ◽  
Deepak Saharan
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Rare Case ◽  
Collision Tumor ◽  
Simultaneous Occurrence ◽  
Rare Entity ◽  
Papillary Thyroid ◽  
Medullary Thyroid ◽  
Cellular Origin

<p>Medullary thyroid carcinoma and papillary thyroid carcinoma are two distinct types of thyroid carcinoma having different cellular origin. The simultaneous occurrence of two distinct neoplasms termed “collision tumour” and it is a rare entity. Sometimes the medullary component does not show calcitonin positivity and hence this becomes a very rare entity. Herein we describe a very rare case of simultaneous occurrence of calcitonin negative medullary thyroid carcinoma and papillary thyroid carcinoma.</p>

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