scholarly journals An Overview on Marine Sponge-Symbiotic Bacteria as Unexhausted Sources for Natural Product Discovery

Diversity ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 40 ◽  
Author(s):  
◽  
◽  
Keyword(s):  
Natural Product ◽  
Marine Sponge ◽  
Symbiotic Bacteria ◽  
Natural Product Discovery

scholarly journals In Situ Natural Product Discovery via an Artificial Marine Sponge

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e100474 ◽  
Author(s):  
James J. La Clair ◽  
Steven T. Loveridge ◽  
Karen Tenney ◽  
Mark O'Neil–Johnson ◽  
Eli Chapman ◽  
...  
Keyword(s):  
Natural Product ◽  
Marine Sponge ◽  
Natural Product Discovery

scholarly journals Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches

2021 ◽  
Author(s):  
Mehdi A. Beniddir ◽  
Kyo Bin Kang ◽  
Grégory Genta-Jouve ◽  
Florian Huber ◽  
Simon Rogers ◽  
...  
Keyword(s):  
Natural Product ◽  
Large Scale ◽  
Scale Analysis ◽  
Computational Tools ◽  
Natural Product Discovery ◽  
Large Scale Analysis ◽  
Metabolite Annotation

This review highlights the key computational tools and emerging strategies for metabolite annotation, and discusses how these advances will enable integrated large-scale analysis to accelerate natural product discovery.

scholarly journals The Tripod for Bacterial Natural Product Discovery: Genome Mining, Silent Pathway Induction, and Mass Spectrometry-Based Molecular Networking

mSystems ◽  
2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Daniela B. B. Trivella ◽  
Rafael de Felicio
Keyword(s):  
Mass Spectrometry ◽  
Natural Products ◽  
Natural Product ◽  
Biosynthetic Pathway ◽  
Genome Mining ◽  
Chemical Compounds ◽  
Gene Clusters ◽  
Tandem Mass ◽  
Molecular Networking ◽  
Natural Product Discovery

ABSTRACT Natural products are the richest source of chemical compounds for drug discovery. Particularly, bacterial secondary metabolites are in the spotlight due to advances in genome sequencing and mining, as well as for the potential of biosynthetic pathway manipulation to awake silent (cryptic) gene clusters under laboratory cultivation. Further progress in compound detection, such as the development of the tandem mass spectrometry (MS/MS) molecular networking approach, has contributed to the discovery of novel bacterial natural products. The latter can be applied directly to bacterial crude extracts for identifying and dereplicating known compounds, therefore assisting the prioritization of extracts containing novel natural products, for example. In our opinion, these three approaches—genome mining, silent pathway induction, and MS-based molecular networking—compose the tripod for modern bacterial natural product discovery and will be discussed in this perspective.

Natural product discovery through microbial genome mining

2021 ◽  
Vol 60 ◽  
pp. 47-54
Author(s):  
Emma Kenshole ◽  
Marion Herisse ◽  
Michael Michael ◽  
Sacha J. Pidot
Keyword(s):  
Natural Product ◽  
Genome Mining ◽  
Microbial Genome ◽  
Natural Product Discovery

Biodiversity of Actinomycetes Associated with Caribbean Sponges and Their Potential for Natural Product Discovery

2013 ◽  
Vol 15 (4) ◽  
pp. 413-424 ◽  
Author(s):  
Jan Vicente ◽  
Allison Stewart ◽  
Bongkeun Song ◽  
Russell T. Hill ◽  
Jeffrey L. Wright
Keyword(s):  
Natural Product ◽  
Natural Product Discovery
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