scholarly journals Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Crystals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 149
Author(s):  
Hui Shi ◽  
Ziqi Zhou ◽  
Wuda Li ◽  
Yuan Fan ◽  
Zhihua Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Polymer Composites ◽  
Bone Tissue ◽  
Building Blocks ◽  
Biological Functions ◽  
Ion Doping ◽  
Comprehensive Introduction ◽  
Surface Modified

Hydroxyapatite (HA) is widely used in bone tissue engineering for its bioactivity and biocompatibility, and a growing number of researchers are exploring ways to improve the physical properties and biological functions of hydroxyapatite. Up to now, HA has been used as inorganic building blocks for tissue engineering or as nanofillers to blend with polymers, furthermore, various methods such as ion doping or surface modification have been also reported to prepare functionalized HA. In this review, we try to give a brief and comprehensive introduction about HA-based materials, including ion-doped HA, HA/polymer composites and surface modified HA and their applications in bone tissue engineering. In addition, the prospective of HA is also discussed. This review may be helpful for researchers to get a general understanding about the development of hydroxyapatite based materials.

scholarly journals THREE-DIMENSIONAL NANOCOMPOSITE SCAFFOLDS FOR BONE TISSUE ENGINEERING: FROM DESIGN TO APPLICATION

Nano LIFE ◽  
2012 ◽  
Vol 02 (01) ◽  
pp. 1250005 ◽  
Author(s):  
BIN DUAN ◽  
MIN WANG ◽  
WILLIAM W. LU
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Rabbit Model ◽  
Bone Morphogenetic Protein 2 ◽  
Human Umbilical Cord ◽  
Porous Structures ◽  
Tissue Engineering Scaffolds ◽  
Surface Modified ◽  
Nanocomposite Scaffolds

Selective laser sintering (SLS), a rapid prototyping technology, was investigated for producing bone tissue engineering scaffolds. Completely biodegradable osteoconductive calcium phosphate (Ca-P)/poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) scaffolds were successfully fabricated via SLS using Ca-P/PHBV nanocomposite microspheres. In the SLS manufacturing route, the architecture of tissue engineering scaffolds (pore shape, size, interconnectivity, etc.) can be designed and the sintering process can be optimized for obtaining scaffolds with desirable porous structures and mechanical properties. SLS was also shown to be very effective in producing highly complex porous structures using nanocomposite microspheres. To render SLS-formed Ca-P/PHBV scaffolds osteoinductive, recombinant human bone morphogenetic protein-2 (rhBMP-2) could be loaded onto the scaffolds. For achieving a controlled release of rhBMP-2 from scaffolds, surface modification of Ca-P/PHBV scaffolds by gelatin entrapment and heparin immobilization was needed. The immobilized heparin provided binding affinity for rhBMP-2. Surface modified Ca-P/PHBV nanocomposite scaffolds loaded with rhBMP-2 enhanced the proliferation of human umbilical cord derived mesenchymal stem cells (hUCMSCs) and also their alkaline phosphatase activity. In in vivo experiments using a rabbit model, surface modified Ca-P/PHBV nanocomposite scaffolds loaded with rhBMP-2 promoted ectopic bone formation, exhibiting their osteoinductivity. The strategy of combining advanced scaffold fabrication, nanocomposite material, and controlled growth factor delivery is promising for bone tissue regeneration.

scholarly journals Polydopamine-Assisted Surface Modification for Bone Biosubstitutes

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Shishu Huang ◽  
Nuanyi Liang ◽  
Yang Hu ◽  
Xin Zhou ◽  
Noureddine Abidi
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Coating Layer ◽  
Tissue Scaffolds ◽  
Surface Modifier ◽  
Biomaterial Surface ◽  
Superior Surface ◽  
Unique Surface

Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented. Secondly, the chemical composition and the underlying formation mechanism of PDA coating layer as a unique surface modifier are interpreted and discussed. Furthermore, several typical examples are provided to evidence the importance of PDA-assisted coating techniques in the construction of bone biosubstitutes and the improvement of material biocompatibility. Nowadays, the application of PDA as a superior surface modifier in multifunctional biomaterials is drawing tremendous interests in bone tissue scaffolds to promote the osteointegration for bone regeneration.

In situ synthesized ceramic–polymer composites for bone tissue engineering: bioactivity and degradation studies

2007 ◽  
Vol 42 (12) ◽  
pp. 4183-4190 ◽  
Author(s):  
Yusuf M. Khan ◽  
Emily K. Cushnie ◽  
John K. Kelleher ◽  
Cato T. Laurencin
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Polymer Composites ◽  
Bone Tissue ◽  
Degradation Studies

Chitosan in Surface Modification for Bone Tissue Engineering Applications

2019 ◽  
Vol 14 (12) ◽  
pp. 1900171 ◽  
Author(s):  
Balakrishnan Abinaya ◽  
Tandiakkal Prakash Prasith ◽  
Badrinath Ashwin ◽  
Syamala Viji Chandran ◽  
Nagarajan Selvamurugan
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications

Surface modification of PLGA/β-TCP scaffold for bone tissue engineering: Hybridization with collagen and apatite

2007 ◽  
Vol 201 (24) ◽  
pp. 9549-9557 ◽  
Author(s):  
Long Pang ◽  
Yunyu Hu ◽  
Yongnian Yan ◽  
Li Liu ◽  
Zhuo Xiong ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue

scholarly journals Mesoporous Silica Based Nanostructures for Bone Tissue Regeneration

2021 ◽  
Vol 8 ◽  
Author(s):  
Sougata Ghosh ◽  
Thomas J. Webster
Keyword(s):  
Tissue Engineering ◽  
Mesoporous Silica ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Mesoporous Silica Nanoparticles ◽  
Fluorescein Isothiocyanate ◽  
Bone Tissue Regeneration ◽  
Surface Modified ◽  
Remarkable Progress

Porous nano-scaffolds provide for better opportunities to restore, maintain, and improve functions of damaged tissues and organs by facilitating tissue regeneration. Various nanohybrids composed of mesoporous silica nanoparticles (MSNs) are being widely explored for tissue engineering. Since biological activity is enhanced by several orders of magnitude in multicomponent scaffolds, remarkable progress has been observed in this field, which has aimed to develop the controlled synthesis of multifunctional MSNs with tuneable pore size, efficient delivering capacity of bioactive factors, as well as enhanced biocompatibility and biodegradability. In this review, we aim to provide a broad survey of the synthesis of multifunctional MSN based nanostructures with exotic shapes and sizes. Further, their promise as a novel nanomedicine is also elaborated with respect to their role in bone tissue engineering. Also, recent progress in surface modification and functionalization with various polymers like poly (l-lactic acid)/poly (ε-caprolactone), polylysine-modified polyethylenimine, poly (lactic-co-glycolic acid), and poly (citrate-siloxane) and biological polymers like alginate, chitosan, and gelatine are also covered. Several attempts for conjugating drugs like dexamethasone and β–estradiol, antibiotics like vancomycin and levofloxaci, and imaging agents like fluorescein isothiocyanate and gadolinium, on the surface modified MSNs are also covered. Finally, the scope of developing orthopaedic implants and potential trends in 3D bioprinting applications of MSNs are also discussed. Hence, MSNs based nanomaterials may serve as improved candidate biotemplates or scaffolds for numerous bone tissue engineering, drug delivery and imaging applications deserving our full attention now.

Stem cell spheroids incorporating fibers coated with adenosine and polydopamine as a modular building blocks for bone tissue engineering

Biomaterials ◽  
2020 ◽  
Vol 230 ◽  
pp. 119652 ◽  
Author(s):  
Taufiq Ahmad ◽  
Hayeon Byun ◽  
Jinkyu Lee ◽  
Sajeesh Kumar Madhurakat Perikamana ◽  
Young Min Shin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Building Blocks ◽  
Cell Spheroids

Surface modification of magnesium with a novel composite coating for application in bone tissue engineering

2022 ◽  
pp. 128078
Author(s):  
Jorgimara de O. Braga ◽  
Diogo M.M. dos Santos ◽  
Fernando Cotting ◽  
Vanessa F.C. Lins ◽  
Nádia M. Leão ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Coating

Surface modification of chitosan film via polydopamine coating to promote biomineralization in bone tissue engineering

2017 ◽  
Vol 33 (2) ◽  
pp. 134-145 ◽  
Author(s):  
Yang Liu ◽  
Zhongxun Zhang ◽  
Huilin Lv ◽  
Yong Qin ◽  
Linhong Deng
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Photoelectron Spectroscopy ◽  
Chitosan Film ◽  
Hydrophobic Surface ◽  
Modified Chitosan ◽  
Potential Applications

Chitosan-based material has been widely used as bone substitute due to its good biocompatibility and biodegradability. However, the hydrophobic surface of chitosan film constrains the osteogenesis mineralization in the process of bone regeneration. For this reason, we develop a novel polydopamine-modified chitosan film suitable for bone tissue engineering applications by a simple and feasible route in this study. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the process of surface modification. For comparison, surface wettability, the capacity of mineralization in vitro, and biocompatibility of the chitosan film and the polydopamine-modified chitosan film were assessed. Research results indicate that the polydopamine-modified chitosan film has good hydrophilicity. It is very evident that the polydopamine treatment significantly influences the biomineralization capacity of the chitosan-based substrates, which enhance the growth rate of apatite on the modified chitosan film. Besides, MC3T3-E1 osteoblast experiments demonstrate that the cells can adhere and grow well on the polydopamine-modified chitosan film. It is anticipated that this polydopamine-modified chitosan film, which can be prepared in large quantities simply, should have potential applications in bone tissue engineering.

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