scholarly journals Purification of Curcumin from Ternary Extract-Similar Mixtures of Curcuminoids in a Single Crystallization Step

Crystals ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 206 ◽  
Author(s):  
Elena Horosanskaia ◽  
Lina Yuan ◽  
Andreas Seidel-Morgenstern ◽  
Heike Lorenz
Keyword(s):  
Crystallization Process ◽  
Product Yield ◽  
Single Step ◽  
Ternary Mixtures ◽  
Cooling Crystallization ◽  
Total Product ◽  
Step Crystallization ◽  
Propanol Solution

Crystallization-based separation of curcumin from ternary mixtures of curcuminoids having compositions comparable to commercial extracts was studied experimentally. Based on solubility and supersolubility data of both, pure curcumin and curcumin in presence of the two major impurities demethoxycurcumin (DMC) and bis(demethoxy)curcumin (BDMC), seeded cooling crystallization procedures were derived using acetone, acetonitrile and 50/50 (wt/wt) mixtures of acetone/2-propanol and acetone/acetonitrile as solvents. Starting from initial curcumin contents of 67–75% in the curcuminoid mixtures single step crystallization processes provided crystalline curcumin free of BDMC at residual DMC contents of 0.6–9.9%. Curcumin at highest purity of 99.4% was obtained from a 50/50 (wt/wt) acetone/2-propanol solution in a single crystallization step. It is demonstrated that the total product yield can be significantly enhanced via addition of water, 2-propanol and acetonitrile as anti-solvents at the end of a cooling crystallization process.

Controlling the Size of Taurine Crystals in the Cooling Crystallization Process

2013 ◽  
Vol 52 (37) ◽  
pp. 13449-13458 ◽  
Author(s):  
Ruohui Lin ◽  
Meng W. Woo ◽  
Cordelia Selomulya ◽  
Jianping Lu ◽  
Xiao Dong Chen
Keyword(s):  
Crystallization Process ◽  
Cooling Crystallization

Micro-/meso-porous stannosilicate composites (Sn-MFI/MCM-41) via two-step crystallization process: Process parameter–phase relationship

2010 ◽  
Vol 136 (1-3) ◽  
pp. 115-125 ◽  
Author(s):  
Prashant S. Niphadkar ◽  
Ajit C. Garade ◽  
Ratnesh K. Jha ◽  
Chandrashekhar V. Rode ◽  
Praphulla N. Joshi
Keyword(s):  
Crystallization Process ◽  
Phase Relationship ◽  
Process Parameter ◽  
Step Crystallization ◽  
Mcm 41

scholarly journals Crystallization of Bi–Sr–Ca–Cu–O glasses in oxygen

1992 ◽  
Vol 7 (7) ◽  
pp. 1658-1671 ◽  
Author(s):  
T.G. Holesinger ◽  
D.J. Miller ◽  
L.S. Chumbley
Keyword(s):  
Electron Microscopy ◽  
Crystallization Process ◽  
Secondary Phases ◽  
X Ray Diffraction ◽  
X Ray ◽  
Partial Crystallization ◽  
Full Conversion ◽  
Limited Process ◽  
Step Crystallization ◽  
Scanning Electron

A detailed study of the crystallization process for compositions near Bi2Sr2Ca1Cu2Oy was undertaken using differential thermal analysis (DTA), transmission and scanning electron microscopy (TEM and SEM), and x-ray diffraction (XRD). Glasses prepared by a splat-quench technique were free of secondary phases in most cases. A two-step crystallization process in oxygen was observed in which partial crystallization of the glass occurs initially with the nucleation of “2201” and Cu2O, and is completed with the formation of SrO, CaO, and Bi2Sr3−xCaxOy. No specific thermal event could be associated with the formation of the “2212” phase. Rather, formation occurs via conversion of 2201 into 2212. This was a kinetically limited process at temperatures below 800 °C as other phases were found to evolve in addition to the 2212 phase during extended anneals. In contrast, a nearly full conversion to the 2212 phase occurred after only 1 min of annealing at 800 °C and above. However, changes in resistivity data, secondary phases, and the measured 2212 composition upon extended anneals at 865 °C showed that considerably longer heat treatments were necessary for the sample to reach its equilibrium state.

Particle engineering by optimization for the unseeded batch cooling crystallization of l-asparagine monohydrate

CrystEngComm ◽  
2017 ◽  
Vol 19 (42) ◽  
pp. 6373-6382 ◽  
Author(s):  
Stutee Bhoi ◽  
Maheswata Lenka ◽  
Debasis Sarkar
Keyword(s):  
Crystallization Process ◽  
Optimization Approach ◽  
Temperature Profiles ◽  
Particle Engineering ◽  
Model Based ◽  
Cooling Crystallization ◽  
Asparagine Monohydrate ◽  
Batch Cooling

A model-based optimization approach is proposed to obtain temperature profiles to achieve the target CSD in a batch cooling crystallization process.

scholarly journals An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from Ostericum koreanum (Max.) Kitagawa

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6555
Author(s):  
Alice Nguvoko Kiyonga ◽  
Gyu Hwan Park ◽  
Hyun Su Kim ◽  
Young-Ger Suh ◽  
Tae Kon Kim ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Crystallization Process ◽  
Raw Material ◽  
Optimal Conditions ◽  
Volatile Organic ◽  
Significant Interest ◽  
Ostericum Koreanum ◽  
One Step ◽  
Central Composite ◽  
Step Crystallization

Ionic liquids (ILs) have attracted significant interest because of their desirable properties. These characteristics have improved their application to overcome the shortcomings of conventional separation techniques for phytochemicals. In this study, several ILs were investigated for their capacity to extract isoimperatorin, a bioactive furanocoumarin, from the roots of Ostericum koreanum. Herein, 1-Butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]) was selected as a promising IL for separating isoimperatorin. A central composite design was applied to optimize the extraction conditions. Under the optimal conditions, the yield of isoimperatorin reached 97.17 ± 1.84%. Additionally, the recovery of isoimperatorin from the [Bmim][BF4] solution was successfully achieved (87.73 ± 2.37%) by crystallization using water as an antisolvent. The purity of the isoimperatorin was greatly enhanced, from 0.26 ± 0.28% in the raw material to 26.94 ± 1.26% in the product, in a one-step crystallization process. Namely, an enhancement of approximately 103-folds was reached. The developed approach overcomes the shortcomings of conventional separation methods applied for gaining isoimperatorin by significantly reducing the laboriousness of the process and the consumption of volatile organic solvents. Moreover, the simplicity and effectiveness of the method are assumed to be valuable for producing isoimperatorin-enriched products and for promoting its purification. This work also confirms the efficiency of ILs as a promising material for the separation of phytochemicals.

scholarly journals Formalized methodology for the separation of three component electrolytic systems: Partial separation of the system

2013 ◽  
Vol 67 (4) ◽  
pp. 569-583
Author(s):  
Midhat Suljkanovic ◽  
Milovan Jotanovic ◽  
Elvis Ahmetovic ◽  
Goran Tadic ◽  
Nidret Ibric
Keyword(s):  
Isothermal Crystallization ◽  
Crystallization Process ◽  
Sodium Sulphate ◽  
Salt Crystallization ◽  
Feed System ◽  
The Third ◽  
Equilibrium Processes ◽  
Cooling Crystallization ◽  
Process Simulator

This work presents a formalized methodology for salt's separation from three component electrolytic systems. The methodology is based on the multi-variant modelling block of a generalized crystallization process, with options for simulating the boundary conditions of feasible equilibrium processes and the elements of crystallization techniques. The following techniques are considered: cooling crystallization, adiabatic evaporative-cooling crystallization, salt-out crystallization, isothermal crystallization, and a combination of the mentioned techniques. The multi-variant options of the crystallization module are based on different variable sets with assigned values for solving mathematical models of generalized crystallization processes. The first level of the methodology begins with the determination of salt crystallization paths from a hypothetical electrolytic AX-BX-H2O system, following by an examination of salt-cooling crystallization possibilities. The second level determines feasible processes by the communication of a feed-system with the environment through a stream of evaporated water, or introduced water with introduced crystallized BX salt. The third level determines the value intervals of the variables for feasible processes. The methodological logic and possibilities for the created process simulator are demonstrated on examples of sodium sulphate separation from the NaCl-Na2SO4-H2O system, using different salt concentrations within the feed system.

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