scholarly journals Development of New Extracts of Crocus sativus L. By-Product from Two Different Italian Regions as New Potential Active Ingredient in Cosmetic Formulations

Cosmetics ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 51
Author(s):  
Maria Rosa Gigliobianco ◽  
Manuela Cortese ◽  
Dolores Vargas Peregrina ◽  
Carla Villa ◽  
Giulio Lupidi ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Skin Irritation ◽  
Sodium Dodecyl ◽  
Water Extract ◽  
Crocus Sativus ◽  
Green Solvents ◽  
Biological Potential ◽  
Italian Regions ◽  
First Time ◽  
Crocus Sativus L

This project aimed to apply eco-friendly extraction methods to Crocus sativus L. by-product (flowers without stigmas i.e., tepals composed of petals and sepals) to recover extracts with high antioxidant capacity and polyphenol content, to be used in cosmetic products. Flowers grown in two different Italian regions (Sample 1—Alba in Piemonte, north of Italy and Sample 2—Sibillini in Marche, centre of Italy) were subjected for the first time to different eco-friendly microwave-mediated green solvents extractions (MGSE) andquali-quantitative determination in antioxidant molecules. Firstly, the extracts from Sample 1 were selected according to their total phenol content (TPC) by Folin–Ciocalteu’s assay and antioxidant capacity (AC) by spectrophotometric assays. Then, according to preliminary results, MGSE carried out in ethanol 70°, water, and glycerin were selected as the most performing methods and applied to both Samples 1 and 2. The best results were obtained using green solvents, such as water or ethanol 70°, for the samples coming from Marche. The identification and quantification of phenolic compounds, belonging to anthocyanins and flavonols classes, was performed by using UPLC-DAD-ESI-MS. Concerning flavonols content, the most abundant analyte is kaempferol 3-O-sophoroside and the extract in water from Sample 1 showed the higher amount of flavonols, reaching the concentration of 25.35 mg of kaempferol 3-O-glucoside equivalent per gram of tepals DW of raw material. Among anthocyanins, the most abundant was delphinidin 3,5-O-diglucoside and the high concentration of anthocyanin was detected in water and ethanol extract. Two new compounds, myricetin-di-glucoside and primflasine, were identified for the first time in Crocus sativus L. by-product by high-resolution mass spectrometry (HRMS). The green batches obtained by extraction were thus characterized and evaluated for their biological potential and safety in keratinocyte HaCaT cells. The extracts were not cytotoxic up to 0.03 mg/mL. The water and ethanol 70° extracts were the most effective in counteracting oxidative stress induced by H2O2 and UVA exposure and reduced cytotoxicity induced by UVB exposure. The water extract was also able to significantly reduce cytotoxicity induced by sodium dodecyl sulphate-induced damage. Taken together, these results suggest a potential use of these waste materials as cosmeceutical preparations such as antiaging, and as anti-skin irritation formulation by-products.

scholarly journals Bioactivity and Bioavailability of the Major Metabolites of Crocus sativus L. Flower

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2827 ◽  
Author(s):  
Moratalla-López ◽  
Bagur ◽  
Lorenzo ◽  
Salinas ◽  
Alonso
Keyword(s):  
Antioxidant Capacity ◽  
Critical Review ◽  
Analytical Methods ◽  
Mechanisms Of Action ◽  
Crocus Sativus ◽  
Crocus Sativus L ◽  
Identification And Quantification

Crocus sativus L. has been cultivated throughout history to obtain its flowers, whose dried stigmas give rise to the spice known as saffron. Crocetin esters, picrocrocin, and safranal are the main metabolites of this spice, which possess a great bioactivity, although the mechanisms of action and its bioavailability are still to be solved. The rest of the flower is composed by style, tepals, and stamens that have other compounds, such as kaempferol and delphinidin, which have an important antioxidant capacity, and these can be applied in foods, phytopharmaceuticals, and cosmetics. The aim of this work was to provide an updated and critical review of the research on the main compounds of Crocus sativus L. flower, including the adequate analytical methods for their identification and quantification, with a focus on their bioactivity and bioavailability.

scholarly journals The studying of bioecological features of saffron (Crocus sativus L.) in Nakhchivan Autonomous Republic

2019 ◽  
Vol 5 (3) ◽  
pp. 22-26
Author(s):  
T. Pashayev ◽  
I. Mammadov
Keyword(s):  
Economic Efficiency ◽  
Scientific Research ◽  
Crocus Sativus ◽  
Water Conditions ◽  
Feeding Area ◽  
Biological Development ◽  
First Time ◽  
Autonomous Republic ◽  
Different Altitudes ◽  
Crocus Sativus L

The article provides information about introduction to Nakhchivan AR and first cultivation of saffron (Crocus sativus L.). For the first time the scientific research works were carried out for to study biological development characteristics and economic indicators of planting saffron in Nakhchivan. Searching for new regions and cultivating large areas for partial repayment of our country’s need for this plant is one of today’s important issues. For this purpose, small quantities of bulbs from Bilgah saffron factory were planted in Nakhchivan Autonomous Republic, and scientific research was started. Experiments have been made to study the effect of the depth of planting, the irradiation and sowing times, the irrigation and water conditions on biological development, flowering and productivity of saffron. Onions of all sizes are planted at depths of 5, 10, 15, 20 cm, keeping 60×10 cm feeding area. All experiments were conducted of the four periods at 15 June, 15 July, 15 August and 1 September with 100 onions in each option. Based on the results of the researches, it is possible to say with confidence that the saffron can be adapted to the sharp continental climat of Nakhchivan Autonomous Republic and can be planted and grown at different altitudes of the region. Given the high profitability and economic efficiency, we believe that the establishment of saffron plantations in the Autonomous Republic will be very important.

scholarly journals Saffron (Crocus sativus L.) Flower Water Extract Disrupts the Cecal Microbiome, Brush Border Membrane Functionality, and Morphology In Vivo (Gallus gallus)

Nutrients ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 220
Author(s):  
Nikita Agarwal ◽  
Nikolai Kolba ◽  
YeonJin Jung ◽  
Jacquelyn Cheng ◽  
Elad Tako
Keyword(s):  
Gene Expression ◽  
Iron Status ◽  
Paneth Cell ◽  
Water Extract ◽  
Gallus Gallus ◽  
Cell Number ◽  
Crocus Sativus ◽  
Dose Dependent ◽  
Crocus Sativus L

Saffron (Crocus sativus L.) is known as the most expensive spice. C. sativus dried red stigmas, called threads, are used for culinary, cosmetic, and medicinal purposes. The rest of the flower is often discarded, but is now being used in teas, as coloring agents, and fodder. Previous studies have attributed antioxidant, anti-inflammatory, hepatoprotective, neuroprotective, anti-depressant, and anticancer properties to C. sativus floral bio-residues. The aim of this study is to assess C. sativus flower water extract (CFWE) for its effects on hemoglobin, brush boarder membrane (BBM) functionality, morphology, intestinal gene expression, and cecal microbiome in vivo (Gallus gallus), a clinically validated model. For this, Gallus gallus eggs were divided into six treatment groups (non-injected, 18 Ω H2O, 1% CFWE, 2% CFWE, 5% CFWE, and 10% CFWE) with n~10 for each group. On day 17 of incubation, 1 mL of the extracts/control were administered in the amnion of the eggs. The amniotic fluid along with the administered extracts are orally consumed by the developing embryo over the course of the next few days. On day 21, the hatchlings were euthanized, the blood, duodenum, and cecum were harvested for assessment. The results showed a significant dose-dependent decrease in hemoglobin concentration, villus surface area, goblet cell number, and diameter. Furthermore, we observed a significant increase in Paneth cell number and Mucin 2 (MUC2) gene expression proportional to the increase in CFWE concentration. Additionally, the cecum microbiome analysis revealed C. sativus flower water extract altered the bacterial populations. There was a significant dose-dependent reduction in Lactobacillus and Clostridium sp., suggesting an antibacterial effect of the extract on the gut in the given model. These results suggest that the dietary consumption of C. sativus flower may have negative effects on BBM functionality, morphology, mineral absorption, microbial populations, and iron status.

Neuentwicklung einer HPLC-Methode zur Qualitätskontrolle von Safran (Crocus sativus L.)

2016 ◽  
Vol 37 (S 01) ◽  
Author(s):  
K Kuchta ◽  
HH Jin ◽  
RW Wang ◽  
HH He ◽  
L Fang ◽  
...  
Keyword(s):  
Crocus Sativus ◽  
Crocus Sativus L

Mapping the “Extra Solvent Power, ESP” of Ionic Liquids for Monomers, Polymers and Globular Nanoparticles

2017 ◽  
Author(s):  
Jose A. Pomposo
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Linear Polymers ◽  
Green Solvents ◽  
Ionic Polymers ◽  
First Time ◽  
Solvent Power

Understanding the miscibility behavior of ionic liquid (IL) / monomer, IL / polymer and IL / nanoparticle mixtures is critical for the use of ILs as green solvents in polymerization processes, and to rationalize recent observations concerning the superior solubility of some proteins in ILs when compared to standard solvents. In this work, the most relevant results obtained in terms of a three-component Flory-Huggins theory concerning the “Extra Solvent Power, ESP” of ILs when compared to traditional non-ionic solvents for monomeric solutes (case I), linear polymers (case II) and globular nanoparticles (case III) are presented. Moreover, useful ESP maps are drawn for the first time for IL mixtures corresponding to case I, II and III. Finally, a potential pathway to improve the miscibility of non-ionic polymers in ILs is also proposed.

Biotechnological Studies in Saffron (Crocus sativus L.) Plant

2017 ◽  
Vol 7 (2) ◽  
pp. 343-352
Author(s):  
YONCA SURGUN ACAR ◽  
RABİA İŞKİL ◽  
BETÜL BÜRÜN
Keyword(s):  
Crocus Sativus ◽  
Crocus Sativus L
Sign in / Sign up

Export Citation Format

Share Document