scholarly journals Two New Dexpanthenol-Containing Wash Gels: Skin Hydration, Barrier Function and Cosmetic Performance upon Single and Repeated Usage in Subjects with Dry Skin

Cosmetics ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 44
Author(s):  
Ana Barrionuevo-Gonzalez ◽  
Sonja Trapp ◽  
Raffaella de Salvo ◽  
Rozalia Olsavszky ◽  
Elena Alina Nanu ◽  
...  

Two novel body/face wash gels enriched with emollient ingredients (including dexpanthenol) were developed for the daily care of dry skin. Two similarly designed 2-week studies (N = 42 each) were conducted to assess the biophysical and cosmetic performance of each of the new wash gels in healthy adults with dry skin. Instrumental measurements quantified the effects of the wash gels on stratum corneum (SC) hydration and transepidermal water loss (TEWL) (with and without a previous sodium lauryl sulfate (SLS) challenge) after single and repeated usage. Following single and repeated applications of the face wash gel to facial skin, as well as to dry SLS-undamaged and SLS-damaged skin of the forearm, skin hydration significantly increased. Similarly, after single and repeated usage of the body wash gel to dry SLS-undamaged and SLS-damaged skin of the forearm, skin moisturization increased significantly from baseline; comparisons with control areas provided inconsistent results for SLS-undamaged skin. No effects on TEWL were observed for either product. Both wash gels were well tolerated and the cosmetic performances were appreciated by the subjects. The study results suggest that daily use of the new wash gels was associated with significant skin-moisturizing effects without adversely affecting skin barrier function and repair.

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 914 ◽  
Author(s):  
Jonghwan Jegal ◽  
No-June Park ◽  
Tae-Young Kim ◽  
Sangho Choi ◽  
Sang Woo Lee ◽  
...  

Plants of the genus Wikstroemia are traditionally used to treat inflammatory diseases like bronchitis and rheumatoid arthritis. In the present study, the anti-atopic effects of an EtOH extract of Wikstroemia dolichantha (WDE) on oxazolone- and DNCB (2,4-dinitrochlorobenzene)-induced dermatitis in mice were investigated. Both ears of BALB/c mice were exposed to oxazolone, and dorsal skins of SKH-1 hairless mice were sensitized with DNCB to induce acute eczematous atopic skin lesions. 1% WDE was applied daily to oxazolone- and DNCB-induced AD mice for two or three weeks, respectively. Total IL-4 and IgE concentrations in serum, transepidermal water loss (TEWL) and skin hydration were assessed. High-performance liquid chromatography/mass spectrometry (HPLC/MS) was used to determine the composition of WDE. Dermal application of 1% WDE grossly and histopathologically improved oxazolone- and DNCB-induced AD skin symptoms. Epidermal thickness and mast cell infiltration were significantly lower in animals treated with WDE than in vehicle controls. Furthermore, in addition to reducing DNCB-induced increases in serum IL-4 (interleukin 4) and IgE (immunoglobulin E) levels, WDE also decreased TEWL and increased skin hydration (indicative of improved skin barrier function). The four flavonoids taxifolin, aromadendrin, padmatin and chamaejasmine were tentatively identified in WDE by HPLC-DAD/QTOF-MS. The above results show WDE protected against oxazolone- and DNCB-induced AD in mice by down-regulating the TH2-associated cytokine IL-4 and improving skin barrier function and suggest WDE might be useful for the management of atopic dermatitis.


2020 ◽  
Author(s):  
Meng Li ◽  
Jian-Xun Mao ◽  
Hang-Hang Jiang ◽  
Chun-Ming Huang ◽  
Xinghua Gao ◽  
...  

Abstract Background: Balanoposthitis is a common inflammatory condition of male genitalia, the microbiota spectrum have not been determined thus far. To profile the microbiome in patients with balanoposthitis (BP), and healthy controls (HC), and investigate its correlation with redundant prepuce, severity of inflammation, and disrupted skin barrier function, including skin pH, Transepidermal Water Loss (TEWL), and skin hydration.Results: In general, the microbiota between BP and HC were similar. The microbiota composition was different between BP and HC with redundant prepuce. Staphylococcus warneri and Prevotella bivia are two most abundant BP-associated Species, and positively correlated with disease severity. The physio-barrier function is markedly impaired in BP, shown by decreased skin hydration, while increased TEWL and pH.Conclusions: Staphylococcus warneri and Prevotella bivia showed a strong correlation with balanoposthitis and may be pathogenic for the condition.


2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Indi Chairunnisa ◽  
Linda Julianti Wijayadi ◽  
Sari Mariyati Dewi Nataprawira

Irritant contact dermatitis (DKI) is a non-immunologic skin inflammation reaction caused by contact with irritants. A janitor is a worker who does a lot of wet work that will repeatedly contact with irritants such as acids, bases, detergents, soap, water, solvents, etc., so that there will be damage to the skin barrier function that starts with loss of the lipid layer and Natural Moisturizing Factor (NMF) so it will reduce skin hydration levels and increase TransEpidermal Water Loss (TEWL). This makes the skin condition becomes dry and the skin defense decreases so that it is easier for DKI. The purpose of this study was to determine the description of skin hydration levels and the incidence of irritant contact dermatitis in janitors at Tarumanagara University. This research is descriptive with a cross-sectional design. A total of 60 people from the janitor became the subject of research. The level of skin hydration is measured by a chronometer. The incidence of DKI in the cleaning staff at Tarumanagara University was 10%, the level of skin hydration in the janitor at Tarumanagara University found hydration levels of dry skin on the right palm (76.7%), left palm (76.7%), back of the hand right (56.7%), and back of the left hand (56.7%). In subjects who experience DKI, levels of hydration of very dry skin on the palm (left-right) and hydration of dry skin on the back of the hand (left-right), and the factors that influence the occurrence of DKI are: gender (female), frequency of washing hands with soap per day, frequency and duration of contact with toilet and floor cleaning products per day and the use of personal protective equipment (PPE), and so it is recommended that cleaners always use PPE when working to prevent DKI and use moisturizers on dry skinABSTRAK:Dermatisis kontak iritan (DKI) adalah suatu reaksi peradangan kulit non-imunologik yang disebabkan oleh kontak dengan bahan iritan. Petugas kebersihan merupakan pekerja yang banyak melakukan pekerjaan basah yang  akan kontak berulang dengan bahan iritan seperti asam, basa, detergen, sabun, air, pelarut, dll, sehingga akan terjadi kerusakan fungsi sawar kulit yang dimulai dengan kehilangan lapisan lipid dan Natural Moisturizing Factor (NMF) sehingga akan menurunkan  kadar hidrasi kulit dan meningkatkan TransEpidermal Water Loss  (TEWL). Hal tersebut membuat kondisi kulit menjadi kering dan pertahanan kulit menurun sehingga lebih mudah terjadi DKI. Tujuan penelitian ini untuk mengetahui gambaran kadar hidrasi kulit dan kejadian dermatitis kontak iritan pada petugas kebersihan di Universitas Tarumanagara. Penelitian ini bersifat deskriptif dengan desain cross sectional. Sejumlah 60 orang dari petugas kebersihan menjadi subjek penelitian. Kadar hidrasi kulit diukur dengan alat korneometer. Angka kejadian DKI pada petugas kebesihan di Universitas Tarumanagara sebesar 10 %, Kadar hidrasi kulit pada petugas kebersihan di Universitas Tarumanagara didapatkan kadar hidrasi kulit  kering pada telapak tangan kanan (76,7%), telapak tangan kiri (76,7%), punggung tangan kanan (56,7%), dan punggung tangan kiri (56,7%). Pada subjek yang mengalami DKI didapatkan kadar hidrasi kulit sangat kering pada telapak tangan(kiri-kanan) dan hidrasi kulit kering  pada punggung tangan (kiri-kanan), dan faktor-faktor yang mempengaruhi kejadian DKI adalah: jenis kelamin (perempuan), frekuensi cuci tangan dengan sabun per hari, frekuensi dan lama kontak dengan produk pembersih toilet maupun lantai per hari dan penggunaan alat pelindung diri (APD), dan sehingga disarankan agar petugas kebersihan selalu memakai APD dengan lengkap saat bekerja untuk mencegah DKI dan menggunakan pelembab pada kulit yang kering


2021 ◽  
Vol 10 (2) ◽  
pp. 359 ◽  
Author(s):  
Trinidad Montero-Vilchez ◽  
María-Victoria Segura-Fernández-Nogueras ◽  
Isabel Pérez-Rodríguez ◽  
Miguel Soler-Gongora ◽  
Antonio Martinez-Lopez ◽  
...  

Multiple diagnostic tools are used to evaluate psoriasis and atopic dermatitis (AD) severity, but most of them are based on subjective components. Transepidermal water loss (TEWL) and temperature are skin barrier function parameters that can be objectively measured and could help clinicians to evaluate disease severity accurately. Thus, the aims of this study are: (1) to compare skin barrier function between healthy skin, psoriatic skin and AD skin; and (2) to assess if skin barrier function parameters could predict disease severity. A cross-sectional study was designed, and epidermal barrier function parameters were measured. The study included 314 participants: 157 healthy individuals, 92 psoriatic patients, and 65 atopic dermatitis patients. TEWL was significantly higher, while stratum corneum hydration (SCH) (8.71 vs. 38.43 vs. 44.39 Arbitrary Units (AU)) was lower at psoriatic plaques than at uninvolved psoriatic skin and healthy controls. Patients with both TEWL > 13.85 g·m−2h−1 and temperature > 30.85 °C presented a moderate/severe psoriasis (psoriasis area severity index (PASI) ≥ 7), with a specificity of 76.3%. TEWL (28.68 vs. 13.15 vs. 11.60 g·m−2 h−1) and temperature were significantly higher, while SCH (25.20 vs. 40.95 vs. 50.73 AU) was lower at AD eczematous lesions than uninvolved AD skin and healthy controls. Patients with a temperature > 31.75 °C presented a moderate/severe AD (SCORing Atopic Dermatitis (SCORAD) ≥ 37) with a sensitivity of 81.8%. In conclusion, temperature and TEWL values may help clinicians to determine disease severity and select patients who need intensive treatment.


1993 ◽  
Vol 6 (2) ◽  
pp. 111-115 ◽  
Author(s):  
J.L. Lévêque ◽  
J. de Rigal ◽  
D. Saint-Léger ◽  
D. Billy

2011 ◽  
Vol 29 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Florian Seyfarth ◽  
Sibylle Schliemann ◽  
Dimitar Antonov ◽  
Peter Elsner

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