scholarly journals The Effect of Transglutaminase to Improve the Quality of Either Traditional or Pectin-Coated Falafel (Fried Middle Eastern Food)

Coatings ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 331 ◽  
Author(s):  
Asmaa Al-Asmar ◽  
C. Giosafatto ◽  
Lucia Panzella ◽  
Loredana Mariniello
Keyword(s):  
Middle Eastern ◽  
Control Sample ◽  
Gastric Digestion ◽  
Oil Uptake ◽  
Coating Solution ◽  
Texture Profile ◽  
Physiological Conditions ◽  
The One

In this study, the effect of transglutaminase (TGase) (5 or 20 U/g of chickpea proteins) on falafel dough was investigated. The resulting falafel balls were either treated or not by dipping them into a pectin (PEC 1%) coating solution. Acrylamide (ACR), oil, and water content were then evaluated. Texture profile analyses and in vitro gastric digestion experiments were also carried out. The ACR content was reduced by 10.8% and by 34.4% in the samples prepared with 5 and 20 U TGase/g, respectively. In PEC-coated samples, the reduction of ACR was equal to 59.3%, 65.3%, and 84.5%, in falafel balls prepared either without TGase or containing 5 U or 20 U of the enzyme, respectively. However, TGase treatment did not affect oil content, while the PEC coating reduced oil uptake by 23.5%. No difference was observed in the texture properties between the control sample and the one dipped in PEC, while these properties changed in samples prepared with the enzyme. Finally, digestion studies, carried out under physiological conditions, demonstrated that the falafels prepared in the presence of TGase were efficiently digested in the gastric environment.

scholarly journals How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Salvatore Giovanni Vitale ◽  
Paola Rossetti ◽  
Francesco Corrado ◽  
Agnese Maria Chiara Rapisarda ◽  
Sandro La Vignera ◽  
...  
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Oocyte Quality ◽  
Fertilization Rate ◽  
In Vitro Models ◽  
The One ◽  
High Level

Assisted reproductive technologies (ART) have experienced growing interest from infertile patients seeking to become pregnant. The quality of oocytes plays a pivotal role in determining ART outcomes. Although many authors have studied how supplementation therapy may affect this important parameter for both in vivo and in vitro models, data are not yet robust enough to support firm conclusions. Regarding this last point, in this review our objective has been to evaluate the state of the art regarding supplementation with melatonin and myo-inositol in order to improve oocyte quality during ART. On the one hand, the antioxidant effect of melatonin is well known as being useful during ovulation and oocyte incubation, two occasions with a high level of oxidative stress. On the other hand, myo-inositol is important in cellular structure and in cellular signaling pathways. Our analysis suggests that the use of these two molecules may significantly improve the quality of oocytes and the quality of embryos: melatonin seems to raise the fertilization rate, and myo-inositol improves the pregnancy rate, although all published studies do not fully agree with these conclusions. However, previous studies have demonstrated that cotreatment improves these results compared with melatonin alone or myo-inositol alone. We recommend that further studies be performed in order to confirm these positive outcomes in routine ART treatment.

scholarly journals A Warning Call for Fertility Preservation Methods for Women Undergoing Gonadotoxic Cancer Treatment

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1340
Author(s):  
Claudia Mehedintu ◽  
Francesca Frincu ◽  
Andreea Carp-Veliscu ◽  
Ramona Barac ◽  
Dumitru-Cristinel Badiu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Fertility Preservation ◽  
Ovarian Reserve ◽  
Negative Impact ◽  
Future Fertility ◽  
Negative Effect ◽  
The One

Malignant hematological conditions have recognized an increased incidence and require aggressive treatments. Targeted chemotherapy, accompanied or not by radiotherapy, raises the chance of defeating the disease, yet cancer protocols often associate long-term gonadal consequences, for instance, diminished or damaged ovarian reserve. The negative effect is directly proportional to the types, doses, time of administration of chemotherapy, and irradiation. Additionally, follicle damage depends on characteristics of the disease and patient, such as age, concomitant diseases, previous gynecological conditions, and ovarian reserve. Patients should be adequately informed when proceeding to gonadotoxic therapies; hence, fertility preservation should be eventually regarded as a first-intention procedure. This procedure is most beneficial when performed before the onset of cancer treatment, with the recommendation for embryos or oocytes’ cryopreservation. If not feasible or acceptable, several options can be available during or after the cancer treatment. Although not approved by medical practice, promising results after in vitro studies increase the chances of future patients to protect their fertility. This review aims to emphasize the mechanism of action and impact of chemotherapy, especially the one proven to be gonadotoxic, upon ovarian reserve and future fertility. Reduced fertility or infertility, as long-term consequences of chemotherapy and, particularly, following bone marrow transplantation, is often associated with a negative impact of recovery, social and personal life, as well as highly decreased quality of life.

scholarly journals Repurposing Existing Medications for Coronavirus Disease 2019: Protocol for a Rapid and Living Systematic Review

2020 ◽  
Author(s):  
Benjamin P. Geisler ◽  
Lara Zahabi ◽  
Adam E. Lang ◽  
Naomi Eastwood ◽  
Elaine Tennant ◽  
...  
Keyword(s):  
Systematic Review ◽  
Middle Eastern ◽  
Length Of Hospital Stay ◽  
Rapid Review ◽  
Future Research ◽  
Review Systematic ◽  
Grade Methodology ◽  
New Evidence

Background: Coronavirus Disease 2019 (COVID-19) has no known specific treatments. However, there might be in vitro and early clinical data as well as evidence from Severe Acute Respiratory Syndrome and Middle Eastern Respiratory Syndrome that could inform clinicians and researchers. This systematic review aims to create priorities for future research of drugs repurposed for COVID-19. Methods: This systematic review will include in vitro, animal, and clinical studies evaluating the efficacy of a list of 34 specific compounds and four groups of drugs identified in a previous scoping review. Studies will be identified both from traditional literature databases and pre-print servers. Outcomes assessed will include time to clinical improvement, time to viral clearance, mortality, length of hospital stay, and proportions transferred to the intensive care unit and intubated, respectively. We will use the GRADE methodology to assess the quality of the evidence. Discussion: The challenge posed by COVID-19 requires not just a rapid review of drugs that can be repurposed but also a sustained effort to integrate new evidence into a living systematic review. Systematic review registration: PROSPERO 2020 CRD42020175648

scholarly journals Use of Milk Fat/Cellulose Ether Emulsions in Spreadable Creams and the Effect of In Vitro Digestion on Texture and Fat Digestibility

Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 796
Author(s):  
Maria Espert ◽  
Teresa Sanz ◽  
Ana Salvador
Keyword(s):  
Milk Fat ◽  
Structural Changes ◽  
In Vitro Digestion ◽  
Cellulose Ether ◽  
Extrusion Force ◽  
Gastric Digestion ◽  
Lipid Digestibility ◽  
Fat Digestibility

This study investigated the texture properties and fat digestibility of new spreadable chocolate creams formulated with an emulsion composed of milk fat and a cellulose ether as a fat source. The spreadability was analysed at 20 °C and compared with a commercial spreadable cream formulated with palm fat. Structural changes in the creams after the in vitro oral and gastric digestion stages were evaluated; lipid digestibility was determined by titration with NaOH during intestinal digestion. Spreadability tests showed the spreads were similar. After oral digestion, the commercial spread showed an increase in extrusion force because of flocculation induced by saliva, an effect not observed in spreads with cellulose ether. Digestibility determination showed lower values for the reformulated spreads. Therefore, milk fat-cellulose ether based emulsions offer an alternative to achieve reformulated spreadable creams, with physical properties similar to those of commercial products but providing reduced fat content and lower lipid digestibility, without compromising the quality of the final product.

scholarly journals Comment on Casiraghi et al. “Mucoadhesive Budesonide Formulation for the Treatment of Eosinophilic Esophagitis” 2020, 12, 211

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 829
Author(s):  
Eyal Zur
Keyword(s):  
Rheological Properties ◽  
Eosinophilic Esophagitis ◽  
Xanthan Gum ◽  
Pharmaceutical Preparation ◽  
Esophageal Tissue ◽  
Specific Formula ◽  
The One

In their article, Casiraghi, A. et al. describe a few relevant methods to assess the quality of a pharmaceutical preparation of oral viscous budesonide, intended to be swallowed, and treat the esophagus in eosinophilic esophagitis patients. They choose the following methods for this purpose: rheological properties, syringeability, mucoadhesiveness, and in vitro penetration of budesonide in porcine esophageal tissue. At the end of the article, they concluded that the best formulation of oral viscous budesonide was the one already being used in hospitals, based on xanthan gum. In their article, the authors did not emphasize that this specific formula was developed by the compounding pharmacist Eyal Zur from Israel and was published eight years before, as part of an article in the International Journal of Pharmaceutical Compounding. The purpose of this comment is to give the appropriate credit to the pharmacist who first developed and published this well designed formulation.

scholarly journals Using different fibers to replace fat in sponge cakes: In vitro starch digestion and physico-structural studies

2018 ◽  
Vol 24 (6) ◽  
pp. 533-543 ◽  
Author(s):  
Elena Diez-Sánchez ◽  
Empar Llorca ◽  
Amparo Quiles ◽  
Isabel Hernando
Keyword(s):  
In Vitro Digestion ◽  
Partial Replacement ◽  
Soluble Fiber ◽  
Sponge Cake ◽  
Texture Profile ◽  
Lower Glucose ◽  
Crumb Structure ◽  
Insoluble Fiber

This study assessed the effect of substituting 30% of fat by soluble, insoluble fiber, or a mix of both fibers in sponge cake quality, structure, acceptability, and starch digestibility. The apparent viscosity of the different formulations was measured and micro-baking was simulated. Texture profile tests were carried out and the crumb structure was examined. In vitro digestion was performed to study the digestibility of starch and a sensory test was carried out to know consumer acceptance. The soluble fiber (maltodextrin) affected the structure and quality of the cakes less than the insoluble fiber (potato fiber) and the use of soluble fiber in the formulation resulted in lower glucose release under in vitro conditions. Moreover, the consumer did not find differences among the control cake and the cakes prepared with soluble fiber. Considering the results as a whole, soluble fiber may be used for partial replacement of fat in sponge cake formulations and may constitute an appropriate strategy for obtaining healthy sponge cakes.

scholarly journals Influence of Oxalis tuberosa pregelatinized flour on rheological properties of gluten-free dough and quality of pan bread

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Salvador Espino-Manzano ◽  
S Espino-Manzano ◽  
Norma Güemes-Vera ◽  
N Güemes-Vera ◽  
Jorge Chanona-Pérez J
Keyword(s):  
Wheat Flour ◽  
Profile Analysis ◽  
Gluten Free ◽  
Free Products ◽  
Oxalis Tuberosa ◽  
Texture Profile ◽  
Pan Bread ◽  
The One ◽  
Home Consumption

Oxalis tuberosa (Ot) is a tuber of Andean origin used mainly for home consumption. The combination of flours and starches used for the production of gluten free products intended mainly for people with celiac disease. The texture properties of dough and bread are measured in the rheological tests texture profile analysis (TPA) and extensibility. Found that increased hardness parameter in the gluten-free dough compared to wheat flour increasing as pregelatinized Oxalis tuberosa (OtP) was added, contrary to the cohesiveness and springiness, diminishing and affected the quality of the final product structure and volume. The treatment supplemented with 10% (T2) of OtP was the one that took a closer control made with wheat flour (TTR) improved behaviour and properties of gluten-free controls (TGF) presenting a lower hardness and cohesiveness more. In the affective sensory evaluation were no significant differences (P> 0.05) between TTR and T2 were found.

scholarly journals Repurposing existing medications for coronavirus disease 2019: protocol for a rapid and living systematic review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Benjamin P. Geisler ◽  
Lara Zahabi ◽  
Adam Edward Lang ◽  
Naomi Eastwood ◽  
Elaine Tennant ◽  
...  
Keyword(s):  
Systematic Review ◽  
Middle Eastern ◽  
Length Of Hospital Stay ◽  
Rapid Review ◽  
Future Research ◽  
Sustained Effort ◽  
Grade Methodology ◽  
New Evidence

Abstract Background Coronavirus disease 2019 (COVID-19) has no confirmed specific treatments. However, there might be in vitro and early clinical data as well as evidence from severe acute respiratory syndrome and Middle Eastern respiratory syndrome that could inform clinicians and researchers. This systematic review aims to create priorities for future research of drugs repurposed for COVID-19. Methods This systematic review will include in vitro, animal, and clinical studies evaluating the efficacy of a list of 34 specific compounds and 4 groups of drugs identified in a previous scoping review. Studies will be identified both from traditional literature databases and pre-print servers. Outcomes assessed will include time to clinical improvement, time to viral clearance, mortality, length of hospital stay, and proportions transferred to the intensive care unit and intubated, respectively. We will use the GRADE methodology to assess the quality of the evidence. Discussion The challenge posed by COVID-19 requires not just a rapid review of drugs that can be repurposed but also a sustained effort to integrate new evidence into a living systematic review. Trial registration PROSPERO 2020 CRD42020175648

scholarly journals Evaluation of the effect of plant material on the quality of cooked sausages

2021 ◽  
pp. 21-26
Author(s):  
A. T. Sarsembekova ◽  
M. Korzeniowska ◽  
Ya. M. Uzakov ◽  
Zh. S. Zheleuova
Keyword(s):  
Sensory Evaluation ◽  
Plant Material ◽  
Profile Analysis ◽  
Objective Assessment ◽  
Control Sample ◽  
Physicochemical Characteristics ◽  
Texture Profile ◽  
Instrumental Color ◽  
Negative Effect

Various amounts of buckwheat hulls (1%, 1,5%, and 3%) were added to cooked turkey sausages. The effect of buckwheat hulls on the physicochemical characteristics of the cooked turkey sausages, including, pH, instrumental color, texture profile analysis (TPA), antioxidant content and sensory evaluation, were determined. Increased levels of added buckwheat hulls led to higher antioxidant activity. However, the protein and fat contents of the cooked turkey sausage samples were constant. The instrumental color in control sample were L*=65,1, a*=5,6, and b*=9,8. There were slight differences in the TPA among the treated samples. According to the results of the sensory and objective assessment of consumer properties, it can be argued that sample F1 with the introduction of buckwheat hulls 3,0% had a negative effect on sensory properties of cooked turkey sausages. The best marks were given to the sample  F1 with the introduction of buckwheat hulls 1,0% on sensory evaluation.

Effect of coating method on release of Glimepiride from porosity osmotic pump tablets (POPTs)

2020 ◽  
pp. 37-45
Keyword(s):  
In Vitro Release ◽  
Osmotic Pump ◽  
Release Time ◽  
Once Daily ◽  
Coating Solution ◽  
Continuous Release ◽  
Red Color ◽  
Coating Method ◽  
Osmotic Agent

In this study, once-daily porosity osmotic pump tablets (POPTs) of Glimepiride were prepared using HPMC K100M (61%), osmotic agent (30% NaCl) coated using two different coating techniques spraying and dipping methods. The coating solution composed of ethyl cellulose (7.5%) w\w in ethanol (90%), castor oil (2%) as water-insoluble plasticizer and Gingo red color (0.5% w\w). In both techniques, the coating level was adjusted to give a 10% increase in the weight of the tablets. The effect of the coating by dipping technique with an increase in the weight of tablet (10 %, 20% & 50%) was also investigated to see the effect coating level on the percentage of drug release from POPTs. The results of the in vitro release of Glimepiride from tablets coated by the spraying method showed longer release time (24 hrs) than those coated with dipping method. On the other hand, increasing the coating level by dipping method retarded the release of the drug from tablets. However, the same retardation effect on release as shown with the spraying technique was only obtained by increasing the coating level with a 50% increase in the weight of the tablet. Thus, coating by spraying is more efficient to prepare POPTs to give a continuous release of Glimepiride from once daily table with the lowest increase in the total weight of the tablet.

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