scholarly journals Early Microbial–Immune Interactions and Innate Immune Training of the Respiratory System during Health and Disease

Children ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 413
Author(s):  
Gustavo Nino ◽  
Carlos E. Rodriguez-Martinez ◽  
Maria J. Gutierrez
Keyword(s):  
Respiratory System ◽  
Early Life ◽  
Respiratory Infections ◽  
Bacterial Colonization ◽  
Innate Immune ◽  
Mucosal Barrier ◽  
Birth Cohorts ◽  
Immune Development ◽  
Key Factor ◽  
Health And Disease

Over the past two decades, several studies have positioned early-life microbial exposure as a key factor for protection or susceptibility to respiratory diseases. Birth cohorts have identified a strong link between neonatal bacterial colonization of the nasal airway and gut with the risk for respiratory infections and childhood asthma. Translational studies have provided companion mechanistic insights on how viral and bacterial exposures in early life affect immune development at the respiratory mucosal barrier. In this review, we summarize and discuss our current understanding of how early microbial–immune interactions occur during infancy, with a particular focus on the emergent paradigm of “innate immune training”. Future human-based studies including newborns and infants are needed to inform the timing and key pathways implicated in the development, maturation, and innate training of the airway immune response, and how early microbiota and virus exposures modulate these processes in the respiratory system during health and disease.

scholarly journals Vertically transferred maternal immune cells promote neonatal immunity against early life infections

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ina Annelies Stelzer ◽  
Christopher Urbschat ◽  
Steven Schepanski ◽  
Kristin Thiele ◽  
Ioanna Triviai ◽  
...  
Keyword(s):  
Immune Cells ◽  
Early Life ◽  
Functional Role ◽  
Respiratory Infections ◽  
Human Cord Blood ◽  
Hematopoietic Stem ◽  
Immune Development ◽  
Early Life Exposure ◽  
First Year Of Life

AbstractDuring mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric cells (MMc) in the offspring is mostly unknown. Here we show a mouse model in which MMc numbers are either normal or low, which enables functional assessment of MMc. We report a functional role of MMc in promoting fetal immune development. MMc induces preferential differentiation of hematopoietic stem cells in fetal bone marrow towards monocytes within the myeloid compartment. Neonatal mice with higher numbers of MMc and monocytes show enhanced resilience against cytomegalovirus infection. Similarly, higher numbers of MMc in human cord blood are linked to a lower number of respiratory infections during the first year of life. Our data highlight the importance of MMc in promoting fetal immune development, potentially averting the threats caused by early life exposure to pathogens.

scholarly journals Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn

2021 ◽  
Vol 12 ◽  
Author(s):  
Cristina Kalbermatter ◽  
Nerea Fernandez Trigo ◽  
Sandro Christensen ◽  
Stephanie C. Ganal-Vonarburg
Keyword(s):  
Immune System ◽  
Breast Milk ◽  
Innate Immune System ◽  
Early Life ◽  
Defense Mechanism ◽  
Adaptive Immune System ◽  
Innate Immune ◽  
Long Term Effects ◽  
Immune Development ◽  
Dietary Antigens

The innate immune system is the oldest protection strategy that is conserved across all organisms. Although having an unspecific action, it is the first and fastest defense mechanism against pathogens. Development of predominantly the adaptive immune system takes place after birth. However, some key components of the innate immune system evolve during the prenatal period of life, which endows the newborn with the ability to mount an immune response against pathogenic invaders directly after birth. Undoubtedly, the crosstalk between maternal immune cells, antibodies, dietary antigens, and microbial metabolites originating from the maternal microbiota are the key players in preparing the neonate’s immunity to the outer world. Birth represents the biggest substantial environmental change in life, where the newborn leaves the protective amniotic sac and is exposed for the first time to a countless variety of microbes. Colonization of all body surfaces commences, including skin, lung, and gastrointestinal tract, leading to the establishment of the commensal microbiota and the maturation of the newborn immune system, and hence lifelong health. Pregnancy, birth, and the consumption of breast milk shape the immune development in coordination with maternal and newborn microbiota. Discrepancies in these fine-tuned microbiota interactions during each developmental stage can have long-term effects on disease susceptibility, such as metabolic syndrome, childhood asthma, or autoimmune type 1 diabetes. In this review, we will give an overview of the recent studies by discussing the multifaceted emergence of the newborn innate immune development in line with the importance of maternal and early life microbiota exposure and breast milk intake.

scholarly journals The importance of intestinal microbiota and its role in the nosocomial infection

2021 ◽  
Vol 10 (10) ◽  
pp. e489101019166 ◽  
Author(s):  
Luisa Ferreira da Cruz ◽  
Israel Lucas Antunes Souza ◽  
Larissa Dias de Souza ◽  
Marcelo Gonzaga de Freitas Araújo ◽  
Paulo Afonso Granjeiro
Keyword(s):  
Nosocomial Infection ◽  
Intestinal Microbiota ◽  
Nosocomial Infections ◽  
Bacterial Colonization ◽  
Intestinal Wall ◽  
Mucosal Barrier ◽  
Microbial Composition ◽  
Metabolic Functions ◽  
Mucosal Barrier Function ◽  
Health And Disease

The gastrointestinal tract houses the largest and most complex community of microorganisms, and this bacterial colonization of the human intestine by environmental microbes begins immediately after the birth. The intestinal microbiota has several important and unique functions, including metabolic functions such as the biotransformation of drugs and the digestion of dietary compounds; a mucosal barrier function by inhibiting the invasion of pathogens and an immunomodulatory function. On the other hand, some commensal bacteria can be pathogenic, causing infections if the natural host is compromised and, in predisposed hosts, the intestinal microbiota can be involved in nosocomial infection. The translocation of bacteria through the intestinal wall is considered one of the main causes of nosocomial infections. The aim of this review is to provide a comprehensive view of the human gut microbiota, its main functions, its role in health and disease, addressing the correlation between intestinal microbial composition and nosocomial infections.

The developing gut microbiota and its consequences for health

2018 ◽  
Vol 9 (6) ◽  
pp. 590-597 ◽  
Author(s):  
M.-J. Butel ◽  
A.-J. Waligora-Dupriet ◽  
S. Wydau-Dematteis
Keyword(s):  
Gut Microbiota ◽  
Time Window ◽  
Disease Risk ◽  
Bacterial Colonization ◽  
Allergic Diseases ◽  
Fetal Life ◽  
Future Health ◽  
Immune Development ◽  
Cesarean Section Delivery ◽  
Health And Disease

AbstractThe developmental origin of health and disease highlights the importance of the period of the first 1000 days (from the conception to the 2 years of life). The process of the gut microbiota establishment is included in this time window. Various perinatal determinants, such as cesarean section delivery, type of feeding, antibiotics treatment, gestational age or environment, can affect the pattern of bacterial colonization and result in dysbiosis. The alteration of the early bacterial gut pattern can persist over several months and may have long-lasting functional effects with an impact on disease risk later in life. As for example, early gut dysbiosis has been involved in allergic diseases and obesity occurrence. Besides, while it was thought that the fetus developed under sterile conditions, recent data suggested the presence of a microbiotain utero, particularly in the placenta. Even if the origin of this microbiota and its eventual transfer to the infant are nowadays unknown, this placental microbiota could trigger immune responses in the fetus and would program the infant’s immune development during fetal life, earlier than previously considered. Moreover, several studies demonstrated a link between the composition of placental microbiota and some pathological conditions of the pregnancy. All these data show the evidence of relationships between the neonatal gut establishment and future health outcomes. Hence, the use of pre- and/or probiotics to prevent or repair any early dysbiosis is increasingly attractive to avoid long-term health consequences.

Agni - Key factor for Shodhananga Snehapana.

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Pavithra. S. ◽  
H. G. Gouda ◽  
Rajalakshmi M. G.
Keyword(s):  
Operative Procedure ◽  
The Other ◽  
Successful Outcome ◽  
Other Hand ◽  
Key Factor ◽  
Health And Disease

Agni is termed as Vaishwanara as it takes the person from Mruthyuloka to Swargaloka. It is an important factor and is equitant to Prana; is one among Dashaprana Ayatana. Agni in Shareera is present in different forms with different actions. It is the responsible factor for both health and disease; on the other hand the successful outcome of treatment is also dependant on Agni. Chikitsa (treatment) is the process of bestowing normalcy which is either brought by Shodhana (purificatory) or Shamana (palliative) Karma. Snehapana is a pre-operative procedure for Shodhana Chikitsa where in Sneha Dravya (medicated fat) is administered for attainment of Upasthita Dosha Avastha and further ease in elimination of the vitiated Doshas. Assessment of Dosha, Dushya, Vyadhi Avastha, Roga Bala, Rogi Bala, Agni, Koshta etc. factors are essential for the attainment of Chikitsa Phala. Assessment of Agni not only helps in understanding Vyadhi but also enables to plan the dosage of Sneha to be administered. Thus this paper is an attempt to throw light on the importance of Agni, assessment of Agni and Agni Bala prior to Shodhananga Snehapana.

scholarly journals The Role of Cell Metabolism in Innate Immune Memory

2020 ◽  
pp. 1-9
Author(s):  
Anaisa Valido Ferreira ◽  
Jorge Domiguéz-Andrés ◽  
Mihai Gheorghe Netea
Keyword(s):  
Metabolic Pathways ◽  
Tricarboxylic Acid Cycle ◽  
Cell Metabolism ◽  
Innate Immune ◽  
Immune Memory ◽  
Functional Changes ◽  
Trained Immunity ◽  
Health And Disease

Immunological memory is classically attributed to adaptive immune responses, but recent studies have shown that challenged innate immune cells can display long-term functional changes that increase nonspecific responsiveness to subsequent infections. This phenomenon, coined <i>trained immunity</i> or <i>innate immune memory</i>, is based on the epigenetic reprogramming and the rewiring of intracellular metabolic pathways. Here, we review the different metabolic pathways that are modulated in trained immunity. Glycolysis, oxidative phosphorylation, the tricarboxylic acid cycle, amino acid, and lipid metabolism are interplaying pathways that are crucial for the establishment of innate immune memory. Unraveling this metabolic wiring allows for a better understanding of innate immune contribution to health and disease. These insights may open avenues for the development of future therapies that aim to harness or dampen the power of the innate immune response.

scholarly journals Evaluation of 16S rRNA primer sets for characterisation of microbiota in paediatric patients with autism spectrum disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
L. Palkova ◽  
A. Tomova ◽  
G. Repiska ◽  
K. Babinska ◽  
B. Bokor ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
16S Rrna ◽  
Dna Amplification ◽  
Disease Status ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Sequencing Analysis ◽  
Key Factor ◽  
Health And Disease ◽  
Primer Sets

AbstractAbstract intestinal microbiota is becoming a significant marker that reflects differences between health and disease status also in terms of gut-brain axis communication. Studies show that children with autism spectrum disorder (ASD) often have a mix of gut microbes that is distinct from the neurotypical children. Various assays are being used for microbiota investigation and were considered to be universal. However, newer studies showed that protocol for preparing DNA sequencing libraries is a key factor influencing results of microbiota investigation. The choice of DNA amplification primers seems to be the crucial for the outcome of analysis. In our study, we have tested 3 primer sets to investigate differences in outcome of sequencing analysis of microbiota in children with ASD. We found out that primers detected different portion of bacteria in samples especially at phylum level; significantly higher abundance of Bacteroides and lower Firmicutes were detected using 515f/806r compared to 27f/1492r and 27f*/1495f primers. So, the question is whether a gold standard of Firmicutes/Bacteroidetes ratio is a valuable and reliable universal marker, since two primer sets towards 16S rRNA can provide opposite information. Moreover, significantly higher relative abundance of Proteobacteria was detected using 27f/1492r. The beta diversity of sample groups differed remarkably and so the number of observed bacterial genera.

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