scholarly journals Vitamin D Status in Children in Greece and Its Relationship with Sunscreen Application

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 111
Author(s):  
Gavriela Maria Feketea ◽  
Ioana Corina Bocsan ◽  
Georgios Tsiros ◽  
Panagiota Voila ◽  
Luminita Aurelia Stanciu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Seasonal Variation ◽  
Children And Adolescents ◽  
Real Life ◽  
Sun Exposure ◽  
Serum Levels ◽  
Normal Serum ◽  
Healthy Children ◽  
25 Hydroxy Vitamin D ◽  
Low Serum

The aim of this study was to characterize the prevalence and seasonal variation of vitamin D (vit D) deficiency/insufficiency in healthy children and adolescents in Greece, and to explore its relationship with the use of sunscreens. The serum level of 25-hydroxy-vitamin D (25(OH)D) was measured in 376 children and adolescents (184 males and 192 females) with a mean age of 7.6 ± 4.9 years, at different time points over a period of 13 months. The prevalence of low serum 25(OH)D level, including deficiency and insufficiency, was 66.2%. The lowest mean 25(OH)D was observed in the month of January (17.9 ± 6.8 ng/mL) and the highest in September, July, August, and October (34.6 ± 8.7, 33.0 ± 9.4, 30.1 ± 8.2, and 30.1 ± 10.6 ng/mL, respectively). Higher levels of serum 25(OH)D were detected in the children to whom sunscreens had been applied on the beach (p = 0.001) or off the beach (p < 0.001). The subjects with deficiency and insufficiency were significantly older than those with normal levels of 25(OH)D, but no significant differences were demonstrated according to gender. This study emphasizes the high prevalence of low serum levels of 25(OH)D and their seasonal variation in children living in a region characterized by many hours of sunshine. Our data suggest that the real-life use of sunscreens during the summer months allows sufficient sunlight to be received to enable production of vit D at a level adequate to maintain normal serum levels. Vit D supplements should be given to children during the months of lower sun exposure.

scholarly journals Vitamin D Status and Its Determinants in a Paediatric Population in Norway

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1385
Author(s):  
Mads N Holten-Andersen ◽  
Johanne Haugen ◽  
Ingvild Oma ◽  
Tor A Strand
Keyword(s):  
Vitamin D ◽  
Seasonal Variation ◽  
Children And Adolescents ◽  
Parental Education ◽  
Sun Exposure ◽  
Late Summer ◽  
Paediatric Population ◽  
Vitamin D Supplementation ◽  
Healthy Children ◽  
Vitamin D Levels

Recommendations for sufficient vitamin D intake in children were recently revised in Norway. However, optimal levels of vitamin D are still debated and knowledge on supplementation and vitamin D levels in healthy children in Norway is scarce. Therefore, we measured the plasma-concentration of 25-hydroxyvitamin D (25(OH)D) in children and adolescents attending the outpatient paediatric clinics in Innlandet Hospital Trust, Norway during two consecutive years (2015–2017). We recruited 301 children and adolescents aged 5 months to 18 years (mean 7.8, SD 4.4 years) for the study and obtained sample material for 25(OH)D measurements from 295 (98%). Information on diet, vitamin D supplementation, sun exposure, ethnicity, parental education and general health was collected by questionnaire. 25(OH)D levels were analysed and determinants for 25(OH)D were estimated by linear regression. 1.0% of the children had deficient levels (25(OH)D < 25 nmol/L) and 21.0% had insufficient levels (25–50 nmol/L). 25(OH)D levels ranging from 50 to 75 nmol/L were found among 38.3%, while 39.7% had levels above 75 nmol/L. The mean 25(OH)D level was 70.0 nmol/L (SD 23.4, range 17–142 nmol/L) with a significant seasonal variation with lowest levels in mid-winter and highest in late summer. In addition to seasonal variation independent determinants for 25(OH)D-levels were age of the child, parental ethnicity, vitamin D supplementation and soda consumption. Along with parental ethnicity other than Nordic, age was the strongest determinant of 25(OH)D, with adolescents having the lowest levels.

scholarly journals Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Leticia Elizondo-Montemayor ◽  
Elena C. Castillo ◽  
Carlos Rodríguez-López ◽  
José R. Villarreal-Calderón ◽  
Merit Gómez-Carmona ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Seasonal Variation ◽  
Vitamin D Deficiency ◽  
High Probability ◽  
Sun Exposure ◽  
Serum Levels ◽  
Lifestyle Factors ◽  
Anthropometric Parameters ◽  
Healthy Older Adults

Vitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. The same cohort was followed during 12 months. Vitamin D deficiency/insufficiency was found in 91.3% of the subjects despite living in appropriate latitude (25°40′0″N). 25(OH)D levels remained below <30 ng/mL through all seasons. Vitamin D deficiency did not correlate to sun exposure or dietary intake. Gender was the strongest associated factor, explaining a variance of 20%. Waist circumference (WC) greater than 88 cm was a risk factor for vitamin D deficiency. Age (>74 years) combined with WC (>88 cm) and BMI (>32.7) showed a high probability (90%) of vitamin D deficiency. Remarkably, an increase in one centimeter in WC decreased 25(OH)D by 0.176 ng/mL, while an increase in one point BMI decreased 25(OH)D by 0.534 ng/mL. A cutoff point of 74 years of age determined probability of vitamin D hipovitaminosis. Vitamin D deficiency was correlated with TNF-αserum levels, possibly increasing the susceptibility of older adults to a proinflammatory state and its related diseases.

Vitamin D status and its associations with components of metabolic syndrome in healthy children

2015 ◽  
Vol 28 (5-6) ◽  
Author(s):  
Ali Awsat Mellati ◽  
Faranak Sharifi ◽  
Soghrat Faghihzade ◽  
Seyed Akbar Mousaviviri ◽  
Hosain Chiti ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Resistance Index ◽  
Sun Exposure ◽  
Hypovitaminosis D ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Low Serum

AbstractHigh prevalence of vitamin D insufficiency/deficiency has been reported in populations of different countries. The aim of this cross-sectional study was to determine the prevalence and association of vitamin D status with components of metabolic syndrome.Lipid profile indices, anthropometric indices [body mass index and waist circumference (WC)], insulin resistance index (HOMA-IR), systolic blood pressure (SBP), diastolic blood pressure (DBP), C-reactive protein, intact parathyroid hormone (iPTH), and serum 25-hydroxyvitamin D [25(OH)D] concentration were evaluated in 297 healthy schoolchildren aged 7–11 years. Multivariate linear regression was used to determine independent predictors associated with low serum 25(OH)D concentrations.The mean serum 25(OH)D concentration was 14.12±8.20 ng/mL (35.3±20.5 nmol/L); 96% of children had low serum 25(OH)D levels, 31.0% were deficient, and 65.0% had insufficient levels of 25(OH)D. Vitamin D deficiency was higher in girls (χThe prevalence of low vitamin D level in the studied healthy children was high and it is correlated with some components of metabolic syndrome. Outdoor activity for optimum sun exposure and additional studies are needed to evaluate the underlying metabolic syndrome components and hypovitaminosis D complications.

scholarly journals Vitamin D Levels in Asymptomatic Children and Adolescents with Atopy during the COVID-19 Era

2021 ◽  
Vol 11 (8) ◽  
pp. 712
Author(s):  
Gavriela Feketea ◽  
Vasiliki Vlacha ◽  
Georgios Tsiros ◽  
Panagiota Voila ◽  
Raluca Maria Pop ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Eosinophil Count ◽  
Immunoglobulin E ◽  
Serum Levels ◽  
Asymptomatic Children ◽  
Vitamin D Levels ◽  
Median Level ◽  
25 Hydroxy Vitamin D ◽  
High Level

This study assessed vitamin D status in asymptomatic children and adolescents in Greece, with and without atopy, and possible changes during the coronavirus disease 2019 (COVID-19) pandemic. Serum levels of 25-hydroxy-vitamin D (25(OH)D) and total immunoglobulin E (IgE), and eosinophil count were measured in 340 asymptomatic children and adolescents (155 males, 185 females), mean age 8.6 ± 4.6 years, recruited over a period of 24 months (February 2019–January 2021). Atopy, defined by high level of IgE for age, was associated with vitamin D deficient status (p = 0.041). Subjects with and without atopy showed similar rates of insufficient and normal levels of 25(OH)D. The median level of 25(OH)D was significantly higher in subjects recruited during the pandemic, when home confinement rules were observed, than before the pandemic, and significantly more children had normal levels of 25(OH)D (p < 0.001), but no differences were noticed for IgE levels or eosinophil count. These results support a link between vitamin D and allergic and infectious inflammations, and specifically the association of vitamin D deficiency with asymptomatic atopy, defined as increased IgE level for age.

Frequency of Combined Deficiencies of Vitamin D and Holotranscobalamin in Cancer Patients.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3674-3674
Author(s):  
Ashley S. Plant ◽  
Glenn Tisman
Keyword(s):  
Vitamin D ◽  
Vitamin B12 ◽  
Cancer Patients ◽  
Sun Exposure ◽  
Serum Levels ◽  
The Elderly ◽  
Vitamin D Insufficiency ◽  
Total Serum ◽  
Low Levels ◽  
Low Serum

Abstract Low serum levels of vitamin D are associated with a higher frequency of at least eleven different malignancies including breast, colon, and prostate cancer (Holick, M.F. Vitamin D: Millenium Perspective. Journal of Cellular Biochemistry. 2003. 88:296–307). Low levels of vitamin B12 were found to contribute to a 2.5–4.0 times greater likelihood of breast cancer in postmenopausal women (Wu, K. et al. Cancer Epidemiol. 1999. 8:209–17) and hematological and mucosal tissue is more sensitive to chemotherapy in the presence of insufficient levels of B12. Only vitamin B12 that is complexed to transcobalamin as holotranscobalamin (HTCII) is metabolically active. It has been suggested that decreased HTCII serum levels are involved in the failure to methylate DNA resulting in the activation of oncogenes that would normally be dormant (Herbert, V. Methyl Metabolism: Epigenetics, Genomics, Proteomics. 2002 FASEB Summer Research Conference. Snowmass Village, Colarado.).Our study investigated vitamin D, total B12 and HTCII levels in 70 cancer patients. Vitamin D was measured as serum 25 OH-D3 (Nichols Advantage assay) and serum B12 was measured as both total B12 and as the metabolically active HTCII (Immulite B12 assay followed by glass adsorption: Vu, T. et al., Am J. Heme42: 202–211 1993). Vitamin D insufficiency has been defined based on differing physiologic sequelae of insufficiency and varies between values less than 50–75 nMol/L. When vitamin D insufficiency is defined as serum level <75nmol/L, 43 of 60 (72%) of cancer patients were found to be insufficient. At a lower definition of insufficiency, <50nmol/L, 24 of 60 patients (40%) were insufficient. Of 52 patients, only 3 (6%) were found to have insufficient serum levels of total B12 (normal >300pg/mL) while 17 of 52 (34%) were found to be HTCII insufficient (normal >69 pg/mL). Of these 17 patients, 14 (84.4%) had normal total B12 levels. Low levels of vitamin D strongly correlated with low serum HTCII. All 12 HTCII deficient patients were vitamin D insufficient at the <75nmol/L standard. Six of 12 HTCII deficient patients (50%) were vitamin D deficient at the <50nmol/L cut off. Chi-squared test for independence revealed a strong relationship between low levels of vitamin D and HTCII. Deficiency of vitamin D (70%) and holotranscobalamin (34%) is prevalent among newly diagnosed patients with cancer. The standard measurement of total serum B12 alone is inadequate for identifying patients with insufficient levels of metabolically active B12. Low vitamin D and holotranscobalamin levels may play a role in cancer development, progression and host response to tumor and therapy. Possible explanations for combined HTCII and D3 deficiency include age, the presence of atrophic gastritis in 30–50% of the elderly, and lack of sun exposure and deficient production of D3 in the elderly. Since both vitamins are conserved by cubulin/megalin mediated renal tubular reabsorption a defect of this mechanism could contribute to deficiency of both vitamins. Study supported in part by ThinkTwice Technologies. This work is dedicated to the memory of Dr. Victor Herbert whose teachings continue to inspire our research efforts.

scholarly journals Low serum levels of vitamin D are associated with anxiety in children and adolescents with dialysis

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Bin Han ◽  
Fu-Xiang Zhu ◽  
Hai-Feng Yu ◽  
Si Liu ◽  
Jun-Liang Zhou
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Serum Levels ◽  
Low Serum

scholarly journals Vitamin D Levels in Children and Adolescents with Cerebral Palsy: Cross-sectional Study / Níveis de Vitamina D em Crianças e Adolescentes com Paralisia Cerebral: Estudo Transversal

2021 ◽  
Vol 4 (3) ◽  
pp. 11938-11949
Author(s):  
Marcela Almeida Linden ◽  
Elizete Aparecida Lomazi ◽  
Gabriel Hessel ◽  
Maria Ângela Bellomo-Brandão
Keyword(s):  
Vitamin D ◽  
Cerebral Palsy ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Sun Exposure ◽  
Food Sources ◽  
Control Group ◽  
Case Group ◽  
Healthy Children ◽  
Vitamin D Levels

Aim: Tetraparetic Cerebral Palsy (TCP) patients may present risks factors for Vitamin D deficiency such as increased risk of malnutrition and possibly infrequent sun exposure. The present study aimed to compare the vitamin D status in this population of TCP pediatric patients (Case Group) and compare them with healthy children and adolescents (Control Group). Methods: The clinical data obtained were: gender, age, weight, height, nutritional status, consumption of vitamin D food sources, sun exposure and serum levels of vitamin D. Vitamin D deficiency was defined as 20 ng/mL or less of 25(OH)D; “insufficiency” was defined as between 21-29 ng/mL; “sufficiency” was defined as between 30-100 ng/mL.1 Results: Sixty patients aged 3 to 20 years old were divided into two groups: the Control Group (n=30) and the Case Group (n=30) composed of individuals with TCP. Vitamin D levels did not differ between groups; the mean levels were 26.65 ng/mL (SD: 10.51) in the Case Group and, 28.93 ng/mL (SD: 9.26) in the Control Group. Conclusion: There was no difference identified between vitamin D levels among TCP and control patients, and no relationship between risk factors and serum 25(OH)D levels was observed. Even though Brazil is a tropical country with abundant sunshine during most of the year, there is still a considerable number of individuals with vitamin D classifications of insufficiency and deficiency in our study (N= 34/60). This should be alarming for healthcare professionals who work with the pediatric population, which is a population at risk for the development of disability.

Low serum levels of 25-hydroxy vitamin D in adults affected by thalassemia major or intermedia

Bone ◽  
2006 ◽  
Vol 38 (6) ◽  
pp. 888-892 ◽  
Author(s):  
N. Napoli ◽  
Enrico Carmina ◽  
Salvatore Bucchieri ◽  
C. Sferrazza ◽  
G.B. Rini ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Levels ◽  
Thalassemia Major ◽  
25 Hydroxy Vitamin D ◽  
Low Serum
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