scholarly journals Pediatric Intestinal Failure Review

Children ◽  
2018 ◽  
Vol 5 (7) ◽  
pp. 100 ◽  
Author(s):  
Nisha Mangalat ◽  
Jeffrey Teckman
Keyword(s):  
Parenteral Nutrition ◽  
Pediatric Patients ◽  
Management Strategies ◽  
Intestinal Failure ◽  
Intestinal Transplantation ◽  
The Body

The term, ‘intestinal failure’, signifies the inability of the body to meet the digestive, absorptive and nutritive needs of the body. As such, these individuals require parenteral nutrition (PN) for survival. The subsequent nutritional, medical and surgical facets to the care are complex. Improved care has resulted in decreased need for intestinal transplantation. This review will examine the unique etiologies and management strategies in pediatric patients with intestinal failure.

Intestinal Transplantation in Pediatric Patients

2002 ◽  
Vol 12 (2) ◽  
pp. 97-115 ◽  
Author(s):  
Beverly Kosmach Park
Keyword(s):  
Medical Management ◽  
Management Strategies ◽  
Intestinal Failure ◽  
Intestinal Transplantation ◽  
Term Survival ◽  
Short Gut Syndrome ◽  
Assessment And Treatment ◽  
Life Threatening ◽  
End Stage ◽  
Intestine Transplantation

Intestine transplantation has evolved into a feasible alternative for children with permanent intestinal failure and life-threatening complications related to total parenteral nutrition. Although the first transplantations were done nearly 40 years ago, long-term survival has only been achieved in the last decade. Nearly 700 intestinal transplantations have been performed internationally since 1985, with an overall patient survival of greater than 50%. Improvements in patient selection, medical management, and assessment and treatment for rejection and infection have contributed to the increased survival. This article will discuss current results and medical management strategies for this innovative type of transplantation for children with end-stage short gut syndrome.

210 Survival Rate and Causes of Death on Home Parenteral Nutrition for Irreversible Intestinal Failure: Implications for Intestinal Transplantation

2010 ◽  
Vol 138 (5) ◽  
pp. S-39
Author(s):  
Loris Pironi ◽  
Francisca Joly ◽  
Alastair Forbes ◽  
Virginie Colomb ◽  
Malgorzata Lyszkowska ◽  
...  
Keyword(s):  
Survival Rate ◽  
Parenteral Nutrition ◽  
Causes Of Death ◽  
Intestinal Failure ◽  
Intestinal Transplantation ◽  
Home Parenteral Nutrition

scholarly journals Clinical Improvement Following Home Parenteral Nutrition in Pediatric Patients with Intestinal Failure

2006 ◽  
Vol 105 (5) ◽  
pp. 399-403 ◽  
Author(s):  
Yi-Ching Tung ◽  
Yen-Hsuan Ni ◽  
Mei-Hwei Chang ◽  
Hong-Shiee Lai ◽  
Der-Yirng Hsieh
Keyword(s):  
Parenteral Nutrition ◽  
Clinical Improvement ◽  
Pediatric Patients ◽  
Intestinal Failure ◽  
Home Parenteral Nutrition

scholarly journals Gut failure and abdominal visceral transplantation

2003 ◽  
Vol 62 (3) ◽  
pp. 727-737 ◽  
Author(s):  
Kareem Abu-Elmagd ◽  
Geoffrey Bond
Keyword(s):  
Central Venous Access ◽  
Health Care Financing ◽  
Small Bowel Transplantation ◽  
Alternative Therapy ◽  
Management Strategies ◽  
Intestinal Failure ◽  
Intestinal Transplantation ◽  
Intestinal Lumen ◽  
High Survival ◽  
Number Of Patients

Despite the reported high survival with total parenteral nutrition (TPN) therapy for patients with intestinal failure, a considerable number of patients do not escape the potential risks of TPN-associated complications, including hepatic failure, vanishing of central venous access and line sepsis. Thus, intestinal, liver-intestinal and multivisceral transplantation have recently emerged to rescue those who can no longer be maintained on TPN. Before this development, and for nearly three decades, small-bowel transplantation was plagued with uncontrolled rejection, graft v. host disease and fatal infection. These barriers stemmed from the large gut lymphoid mass and heavy microbial load contained in the intestinal lumen. The recent improvement in survival after the clinical introduction of tacrolimus with achievement of full enteric nutritional autonomy qualified the procedure by the US Health Care Financing Administration as the standard of care for patients with intestinal and TPN failure. The decision was supported by a decade of clinical experience with cumulative improvement in patient and graft survival. In addition, the introduction of new effective immunoprophylactic agents and novel therapeutic approaches has contributed to a further increase in the therapeutic advantages of the procedure. The present review article outlines the current clinical practice of intestinal transplantation and defines new management strategies with the aim of raising the level of the procedure to be a better alternative therapy for TPN-dependent patients.

CO13 ANALYSIS OF THE IMPACT OF PARENTERAL NUTRITION ON THE DAILY LIFE OF PEDIATRIC PATIENTS WITH INTESTINAL FAILURE

2011 ◽  
Vol 43 ◽  
pp. S402
Author(s):  
M.I. Spagnuolo ◽  
I. Liguoro ◽  
F. Chiatto ◽  
M.A. Caiazzo ◽  
N. Baiano ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Pediatric Patients ◽  
Daily Life ◽  
Intestinal Failure ◽  
The Impact
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