scholarly journals Endocrine Disorders in Childhood Cancer Survivors Treated with Haemopoietic Stem Cell Transplantation

Children ◽  
2014 ◽  
Vol 1 (1) ◽  
pp. 48-62 ◽  
Author(s):  
Christina Wei ◽  
Assunta Albanese
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Cell Transplantation ◽  
Childhood Cancer Survivors ◽  
Endocrine Disorders ◽  
Haemopoietic Stem Cell ◽  
Haemopoietic Stem Cell Transplantation

Late effects and quality of life of childhood cancer survivors: Part 1. Impact of stem cell transplantation

2010 ◽  
Vol 91 (5) ◽  
pp. 865-876 ◽  
Author(s):  
Yasushi Ishida ◽  
Misato Honda ◽  
Shuichi Ozono ◽  
Jun Okamura ◽  
Keiko Asami ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Cell Transplantation ◽  
Late Effects ◽  
Childhood Cancer Survivors

scholarly journals Restoring Fertility in Sterile Childhood Cancer Survivors by Autotransplanting Spermatogonial Stem Cells: Are We There Yet?

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Robert B. Struijk ◽  
Callista L. Mulder ◽  
Fulco van der Veen ◽  
Ans M. M. van Pelt ◽  
Sjoerd Repping
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cancer Survivors ◽  
Cancer Treatment ◽  
Childhood Cancer ◽  
Cell Transplantation ◽  
Childhood Cancer Survivors ◽  
Spermatogonial Stem Cells ◽  
Spermatogonial Stem Cell

Current cancer treatment regimens do not only target tumor cells, but can also have devastating effects on the spermatogonial stem cell pool, resulting in a lack of functional gametes and hence sterility. In adult men, fertility can be preserved prior to cancer treatment by cryopreservation of ejaculated or surgically retrieved spermatozoa, but this is not an option for prepubertal boys since spermatogenesis does not commence until puberty. Cryopreservation of a testicular biopsy taken before initiation of cancer treatment, followed byin vitropropagation of spermatogonial stem cells and subsequent autotransplantation of these stem cells after cancer treatment, has been suggested as a way to preserve and restore fertility in childhood cancer survivors. This strategy, known as spermatogonial stem cell transplantation, has been successful in mice and other model systems, but has not yet been applied in humans. Although recent progress has brought clinical application of spermatogonial stem cell autotransplantation in closer range, there are still a number of important issues to address. In this paper, we describe the state of the art of spermatogonial stem cell transplantation and outline the hurdles that need to be overcome before clinical implementation.

scholarly journals Transplant characteristics and self-reported pulmonary outcomes in Swiss childhood cancer survivors after hematopoietic stem cell transplantation—a cohort study

2020 ◽  
Author(s):  
Maria Otth ◽  
◽  
Christina Schindera ◽  
Tayfun Güngör ◽  
Marc Ansari ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Childhood Cancer Survivors ◽  
Hematopoietic Stem ◽  
Increased Risk

AbstractChildhood cancer survivors treated with hematopoietic stem cell transplantation are at high risk for pulmonary morbidity and mortality. In this retrospective study we described transplant characteristics of pediatric patients who underwent hematopoietic stem cell transplantation in Switzerland and how these characteristics changed over time, compared self-reported pulmonary outcomes between transplanted and non-transplanted survivors, and investigated risk factors for the reported pulmonary outcomes. As part of the population-based Swiss Childhood Cancer Survivor Study, we sent questionnaires to all ≥5-year childhood cancer survivors diagnosed 1976–2010 at age ≤20 years. We included 132 transplanted survivors and 368 matched non-transplanted survivors. During the study period transplant characteristics changed, with decreasing use of total body irradiation and increased use of peripheral blood stem cells and mismatched and unrelated donors as transplant source. One-fifth of transplanted survivors (20%, 95%CI 13–27%) and 18% of non-transplanted survivors (95%CI 13–21%) reported at least one pulmonary outcome. None of the analyzed factors was significantly associated with an increased risk of pulmonary outcomes in multivariable analysis. We found that pulmonary outcomes were frequently reported in transplanted and non-transplanted childhood cancer survivors, indicating a strong need for long-term pulmonary follow-up care.

Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study

The Lancet ◽  
2002 ◽  
Vol 360 (9327) ◽  
pp. 130-137 ◽  
Author(s):  
Isabelle André-Schmutz ◽  
Françoise Le Deist ◽  
Salima Hacein-Bey-Abina ◽  
Ellen Vitetta ◽  
John Schindler ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Immune Reconstitution ◽  
Phase 1 ◽  
Host Disease ◽  
Graft Versus Host ◽  
Haemopoietic Stem Cell ◽  
Haemopoietic Stem Cell Transplantation
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