scholarly journals Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2624
Author(s):  
Maria Anele Romeo ◽  
Roberta Santarelli ◽  
Maria Saveria Gilardini Montani ◽  
Roberta Gonnella ◽  
Rossella Benedetti ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Kaposi Sarcoma ◽  
Cell Types ◽  
Barr Virus ◽  
Human Herpes Virus ◽  
Autophagic Process ◽  
Epstein Barr ◽  
Herpès Virus ◽  
Different Cell Types

Human Herpes Virus-6 (HHV-6), Epstein-Barr Virus (EBV) and Kaposi Sarcoma Herpes Virus (KSHV) are viruses that share with other member of the Herpesvirus family the capacity to interfere with the autophagic process. In this paper, mainly based on the findings of our laboratory, we describe how, through different mechanisms, these viruses converge in reducing autophagy to impair DC immune function and how, by infecting and dysregulating autophagy in different cell types, they promote the pathologies associated with their infection, from the neurodegenerative diseases such Alzheimer’s disease to cancer.

scholarly journals Profound CD4+ T lymphocytopenia in human immunodeficiency virus negative individuals, improved with anti-human herpes virus treatment

2012 ◽  
pp. 305-311 ◽  
Author(s):  
María Lilia Diaz Betancourth ◽  
Julio Cesar Klinger ◽  
Victoria Eugenia Niño
Keyword(s):  
Human Immunodeficiency Virus ◽  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Viral Infections ◽  
Human Herpes ◽  
Barr Virus ◽  
Human Herpes Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Herpès Virus

Lymphocytopenia and CD4+ T lymphocytopenia can be associated with many bacterial, fungal, parasite and viral infections. They can also be found in autoimmune and neoplastic diseases, common variable immu­nodeficiency syndrome, physical, psychological and traumatic stress, malnutrition and immunosuppressive therapy. Besides, they can also be brought into relation, without a known cause, with idiopathic CD4+ T lym­phocytopenia. Among viral infections, the Retrovirus, specially the human immunodeficiency virus, is the most frequently cause. However, many acute viral infections, including cytomegalovirus and Epstein Barr virus can be associated with transient lymphocytopenia and CD4+ T lymphocytopenia. As is well known, transient lymphocytopenia and CD4+ T lymphocytopenia are temporary and overcome when the disease improves. Nonetheless, severe CD4+ T Lymphocytopenia associated with chronic infections by human herpes virus has not been reported. We describe 6 cases of human immunodeficiency virus negative patients, with chronic cytomegalovirus and Epstein Barr virus infections and profound lymphocytopenia with clinical symptoms of cellular immunodeficiency. These patients improved rapidly with ganciclovir or valganciclovir treatment. We claim here that it is important to consider the chronic human herpes virus infection in the differential diag­nosis of profoundly CD4+ T lymphocytopenia etiology, when human immunodeficiency virus is absent, in order to start effective treatment and to determine, in future studies, the impact of chronic human herpes virus infection in human beings’ health.

scholarly journals Epstein–Barr Virus and Human Herpes Virus-8 are not Associated with Juvenile Nasopharyngeal Angiofibroma

2008 ◽  
Vol 2 (3) ◽  
pp. 145-149 ◽  
Author(s):  
Román Carlos ◽  
Lester D. R. Thompson ◽  
Ana Carolina Netto ◽  
Luiz Gustavo Garcia Santos Pimenta ◽  
Jeane de Fátima Correia-Silva ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Juvenile Nasopharyngeal Angiofibroma ◽  
Human Herpes ◽  
Nasopharyngeal Angiofibroma ◽  
Human Herpes Virus 8 ◽  
Barr Virus ◽  
Human Herpes Virus ◽  
Epstein Barr ◽  
Herpès Virus

Epstein-Barr Virus and Human herpes virus 6 Type A DNA Enhance IL-17 Production in Mice

2015 ◽  
Vol 28 (5) ◽  
pp. 297-302 ◽  
Author(s):  
Elias A. Rahal ◽  
Helene Hajjar ◽  
Mirna Rajeh ◽  
Bassem Yamout ◽  
Alexander M. Abdelnoor
Keyword(s):  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Type A ◽  
Human Herpes ◽  
Barr Virus ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6 ◽  
Epstein Barr ◽  
Herpès Virus

The Biochemistry of Bereavement: Possible Basis for Chemotherapy?

1983 ◽  
Vol 13 (4) ◽  
pp. 295-303 ◽  
Author(s):  
Jerome F. Fredrick
Keyword(s):  
Infectious Disease ◽  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Barr Virus ◽  
Adrenal Axis ◽  
Epstein Barr ◽  
Herpès Virus ◽  
Pituitary Adrenal Axis ◽  
Increased Susceptibility

The effect of acute grief on the pituitary-adrenal axis and the hypersecretion of cortisol is reviewed. Particular attention is devoted to the immunosuppressive effects of this hypersecretion. The increased susceptibility to infectious disease agents—bacterial, fungal and viral—is explored in terms of the altered biochemistry of the bereaved individual. The probable increased susceptibility towards oncogenic “passenger” viruses, such as the Epstein-Barr Virus and the Herpes Virus, is discussed as a possible mechanism for the increased incidence of malignancies in the bereaved. The use of dexamethasone in preventing hypersecretion of cortisol in the bereaved, as well as the use of L-dopa and clonidine to control A.C.T.H. levels in such individuals, has given rise to much conflicting data in recent studies. The use of antibiotics in a prophylactic sense, to bolster falling immunity during the grief period, remains a distinct possibility. However, until the basic reactions of grief are defined and the altered biochemistry established, it appears that psychological methods offer the best therapeutic means.

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