scholarly journals Estrogen Actions in Triple-Negative Breast Cancer

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2358 ◽  
Author(s):  
Oliver Treeck ◽  
Susanne Schüler-Toprak ◽  
Olaf Ortmann
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Triple Negative Breast Cancer ◽  
Survival Data ◽  
Triple Negative ◽  
Estrogen Signaling ◽  
Original Research ◽  
Pubmed Database ◽  
Meta Analyses ◽  
Therapy Strategies

Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC. Estrogen signaling in TNBC can also be activated and modulated by the constitutively active estrogen-related receptors (ERRs). In this review article, we discuss the role of ERβ and GPER-1 as mediators of E2 action in TNBC as well as the function of ERRs as activators and modulators of estrogen signaling in this cancer entity. For this purpose, original research articles on estrogen actions in TNBC were considered, which are listed in the PubMed database. Additionally, we performed meta-analyses of publicly accessible integrated gene expression and survival data to elucidate the association of ERβ, GPER-1, and ERR expression levels in TNBC with survival. Finally, options for endocrine therapy strategies for TNBC were discussed.

scholarly journals Agonists and knockdown of estrogen receptor β differentially affect invasion of triple-negative breast cancer cells in vitro

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Susanne Schüler-Toprak ◽  
Julia Häring ◽  
Elisabeth C. Inwald ◽  
Christoph Moehle ◽  
Olaf Ortmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Estrogen Receptor Β

scholarly journals The expression and clinical significance of GADD45A in breast cancer patients

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5344 ◽  
Author(s):  
Junnan Wang ◽  
Yiran Wang ◽  
Fei Long ◽  
Fengshang Yan ◽  
Ning Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Patients ◽  
Clinical Significance ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Breast Cancer Patients ◽  
Ki 67 ◽  
Expression Levels ◽  
Cancer Tissues

BackgroundGrowth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) was previously found to be associated with risk of several kinds of human tumors. Here, we studied the expression and clinical significance of GADD45A in breast cancer.MethodsWe performed an immunohistochemical study of GADD45A protein from 419 breast cancer tissues and 116 adjacent non-neoplastic tissues.ResultsSignificantly high GADD45A expression were observed in breast cancer tissues compared with adjacent non-neoplastic tissues (P < 0.001) and were independently correlative with estrogen receptor negative (P = 0.028) and high Ki-67 index (P < 0.001). Kaplan–Meier survival analysis revealed that patients with high GADD45A expression levels had a worse long-term prognosis in triple negative breast cancer (P = 0.041), but it was not an independent prognostic factor in multivariate analysis (P = 0.058).ConclusionsGADD45A expression levels are significantly correlative with estrogen receptor status and Ki-67 index in human breast cancer. Patients with triple negative breast cancer might be stratified into high risk and low risk groups based on the GADD45A expression levels.

scholarly journals Triple-negative breast cancer that progressed as estrogen receptor-positive skin metastases

2015 ◽  
Vol 30 (3) ◽  
pp. 411 ◽  
Author(s):  
Sang Min Lee ◽  
Eun Jin Kang ◽  
Ju Hee Kim ◽  
Jong Min Yun ◽  
Der Sheng Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Positive Skin ◽  
Skin Metastases ◽  
Estrogen Receptor Positive

scholarly journals Alcohol, smoking, and risk of H er2‐overexpressing and triple‐negative breast cancer relative to estrogen receptor‐positive breast cancer

2018 ◽  
Vol 143 (8) ◽  
pp. 1849-1857 ◽  
Author(s):  
Michelle L. Baglia ◽  
Linda S. Cook ◽  
C. Mei‐Tzu ◽  
Charles Wiggins ◽  
Deirdre Hill ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Estrogen Receptor Positive ◽  
Positive Breast Cancer
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