scholarly journals The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1886
Author(s):  
Fabio Perrotta ◽  
Angelica Perna ◽  
Klara Komici ◽  
Ersilia Nigro ◽  
Mariano Mollica ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Myocardial Cell ◽  
Endothelial Progenitor ◽  
Mortality And Morbidity ◽  
Regulatory Pathways ◽  
Ischemic Disease ◽  
Calcium Modulation ◽  
Disease Biology ◽  
Proliferation And Differentiation

Ischemic heart disease is currently a major cause of mortality and morbidity worldwide. Nevertheless, the actual therapeutic scenario does not target myocardial cell regeneration and consequently, the progression toward the late stage of chronic heart failure is common. Endothelial progenitor cells (EPCs) are bone marrow-derived stem cells that contribute to the homeostasis of the endothelial wall in acute and chronic ischemic disease. Calcium modulation and other molecular pathways (NOTCH, VEGFR, and CXCR4) contribute to EPC proliferation and differentiation. The present review provides a summary of EPC biology with a particular focus on the regulatory pathways of EPCs and describes promising applications for cardiovascular cell therapy.

scholarly journals Effects of Brain-Derived Neurotrophic Factor on MicroRNA Expression Profile in Human Endothelial Progenitor Cells

2018 ◽  
Vol 27 (6) ◽  
pp. 1005-1009 ◽  
Author(s):  
Tongrong He ◽  
Ruohan Sun ◽  
Ying Li ◽  
Zvonimir S. Katusic
Keyword(s):  
Endothelial Cells ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Endothelial Progenitor ◽  
Regenerative Capacity ◽  
Proliferation And Differentiation ◽  
Guanylate Binding Protein

The mechanisms underlying proangiogenic function of brain-derived neurotrophic factor (BDNF) are not fully understood. The current study was designed to explore the microRNA (miRNA) profile in human early endothelial progenitor cells (EPCs, also referred to as CFU-Hill cells) treated with BDNF. Treatment of early EPCs with BDNF for 7 d significantly increased the colony formation of outgrowth endothelial cells. BDNF suppressed the expression of miR-4716-5p, miR-3928, miR-433, miR-1294, miR-1539, and miR-19b-1*. In contrast, BDNF significantly increased the levels of miR-432*, miR-4499, miR-3911, miR-1183, miR-4669, miR-636, miR-4717-3p, miR-4298, miR485-5p, and miR-181c. Since miR-433 has been reported to augment hematopoietic cells proliferation and differentiation, we examined the role of miR-433 in regenerative effects of BDNF. BDNF stimulated the protein expression of guanylate-binding protein 2 via the suppression of miR-433. However, the knockdown of miR-433 was not sufficient to significantly increase the number of outgrowth endothelial cell colonies, suggesting that modulation of miR-433 alone does not stimulate regenerative capacity of EPCs. In aggregate, our results also suggest that the effect of BDNF on regenerative function of EPCs may depend on complex changes in the expression of microRNAs.

Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro

2004 ◽  
Vol 300 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Martin Butzal ◽  
Sonja Loges ◽  
Michaela Schweizer ◽  
Uta Fischer ◽  
Ursula M. Gehling ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Proliferation And Differentiation

Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro

2007 ◽  
Vol 357 (4) ◽  
pp. 1016-1020 ◽  
Author(s):  
Sonja Loges ◽  
Martin Butzal ◽  
Jasmin Otten ◽  
Michaela Schweizer ◽  
Uta Fischer ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Proliferation And Differentiation

scholarly journals T17b murine embryonal endothelial progenitor cells can be induced towards both proliferation and differentiation in a fibrin matrix

2009 ◽  
Vol 13 (5) ◽  
pp. 926-935 ◽  
Author(s):  
Oliver Bleiziffer ◽  
Raymund E. Horch ◽  
Matthias Hammon ◽  
Andreas Arkudas ◽  
Elisabeth Naschberger ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Fibrin Matrix ◽  
Proliferation And Differentiation
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