scholarly journals Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1391
Author(s):  
Aaron H. Wasserman ◽  
Manigandan Venkatesan ◽  
Aitor Aguirre
Keyword(s):  
Cardiovascular Disease ◽  
Stem Cell Differentiation ◽  
Therapeutic Strategies ◽  
Lipid Signaling ◽  
Liquid Chromatography Mass Spectrometry ◽  
Bioactive Lipids ◽  
Cardiovascular Regeneration ◽  
Cardiovascular Biology ◽  
Health And Disease ◽  
Novel Therapeutic Strategies

Cardiovascular disease (CVD) remains a leading cause of death globally. Understanding and characterizing the biochemical context of the cardiovascular system in health and disease is a necessary preliminary step for developing novel therapeutic strategies aimed at restoring cardiovascular function. Bioactive lipids are a class of dietary-dependent, chemically heterogeneous lipids with potent biological signaling functions. They have been intensively studied for their roles in immunity, inflammation, and reproduction, among others. Recent advances in liquid chromatography-mass spectrometry techniques have revealed a staggering number of novel bioactive lipids, most of them unknown or very poorly characterized in a biological context. Some of these new bioactive lipids play important roles in cardiovascular biology, including development, inflammation, regeneration, stem cell differentiation, and regulation of cell proliferation. Identifying the lipid signaling pathways underlying these effects and uncovering their novel biological functions could pave the way for new therapeutic strategies aimed at CVD and cardiovascular regeneration.

scholarly journals Microbial Interkingdom Biofilms and the Quest for Novel Therapeutic Strategies

2021 ◽  
Vol 9 (2) ◽  
pp. 412
Author(s):  
Katrien Van Dyck ◽  
Rita M. Pinto ◽  
Durgasruthi Pully ◽  
Patrick Van Dijck
Keyword(s):  
Bacterial Species ◽  
Treatment Strategies ◽  
Drug Tolerance ◽  
Therapeutic Strategies ◽  
Bacterial Biofilm ◽  
Clinical Settings ◽  
Bacterial Interactions ◽  
Health And Disease ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Fungal and bacterial species interact with each other within polymicrobial biofilm communities in various niches of the human body. Interactions between these species can greatly affect human health and disease. Diseases caused by polymicrobial biofilms pose a major challenge in clinical settings because of their enhanced virulence and increased drug tolerance. Therefore, different approaches are being explored to treat fungal–bacterial biofilm infections. This review focuses on the main mechanisms involved in polymicrobial drug tolerance and the implications of the polymicrobial nature for the therapeutic treatment by highlighting clinically relevant fungal–bacterial interactions. Furthermore, innovative treatment strategies which specifically target polymicrobial biofilms are discussed.

scholarly journals Brain ependymocytes in neurogenesis and maintaining integrity of blood-cerebrospinal fluid barrier

2019 ◽  
Vol 4 (3) ◽  
pp. 83-94
Author(s):  
Yu. A. Uspenskaya ◽  
A. V. Morgun ◽  
E. D. Osipova ◽  
S. K. Antonova ◽  
A. B. Salmina
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurological Disorders ◽  
Cell Biology ◽  
Ependymal Cell ◽  
Therapeutic Strategies ◽  
Normal Functioning ◽  
The Central Nervous System ◽  
Health And Disease ◽  
Novel Therapeutic Strategies ◽  
The Brain

Here we review the physiology of brain ependymocytes which produce cerebrospinal fluid, regulate neurogenic niches, and contribute to neurogenesis in health and disease. We particularly focus on cilia as these organelles are pivotal to ensure the normal functioning of ependymocytes. The functional activity of ependymocytes is largely defined by their localisation in the central nervous system. Further studies of ependymal cell biology are required to better understand the mechanisms of neurological disorders and to discover novel therapeutic strategies aimed at correcting neurodegeneration and aberrant development of the brain.

Sign in / Sign up

Export Citation Format

Share Document