scholarly journals Pluripotent-Stem-Cell-Derived Hepatic Cells: Hepatocytes and Organoids for Liver Therapy and Regeneration

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 420 ◽  
Author(s):  
Antonietta Messina ◽  
Eléanor Luce ◽  
Marwa Hussein ◽  
Anne Dubart-Kupperschmitt
Keyword(s):  
Pluripotent Stem Cells ◽  
Pluripotent Stem Cell ◽  
3D Culture ◽  
Liver Support ◽  
Hepatic Cells ◽  
Number Of Patients ◽  
Extracorporeal Liver Support ◽  
Liver Support Devices ◽  
Support Devices ◽  
Complex Organ

The liver is a very complex organ that ensures numerous functions; it is thus susceptible to multiple types of damage and dysfunction. Since 1983, orthotopic liver transplantation (OLT) has been considered the only medical solution available to patients when most of their liver function is lost. Unfortunately, the number of patients waiting for OLT is worryingly increasing, and extracorporeal liver support devices are not yet able to counteract the problem. In this review, the current and expected methodologies in liver regeneration are briefly analyzed. In particular, human pluripotent stem cells (hPSCs) as a source of hepatic cells for liver therapy and regeneration are discussed. Principles of hPSC differentiation into hepatocytes are explored, along with the current limitations that have led to the development of 3D culture systems and organoid production. Expected applications of these organoids are discussed with particular attention paid to bio artificial liver (BAL) devices and liver bio-fabrication.

scholarly journals Extracorporeal liver support devices in the ICU

2016 ◽  
Author(s):  
Rajiv Jalan ◽  
Banwari Agarwal
Keyword(s):  
Liver Failure ◽  
Definitive Treatment ◽  
Current Evidence ◽  
High Morbidity ◽  
Liver Support ◽  
Transporter Protein ◽  
Extracorporeal Liver Support ◽  
Mechanical Devices ◽  
Liver Support Devices ◽  
Support Devices

Liver failure is common and carries high morbidity and mortality. Liver transplantation (LT) is the only definitive treatment available performed as an emergency in acute liver failure and electively for chronic liver disease. In the last 50 years, a number of extracorporeal liver support devices and modifications have emerged , some of them purely mechanical in nature aimed at detoxification, while others are cell based systems possessing bio-transformational capability. Mechanical devices are mainly based on albumin dialysis, albumin being a key transporter protein that is severely deficient and irreversibly destroyed in liver diseases. Despite a sound scientific rationale and good safety profile, none of the currently available devices have shown enough promise to be incorporated in routine clinical practice, their use being limited to specific clinical situations. This chapter describes currently available devices, their operational characteristics, current evidence of their utility and limitation, and the future developments in the field of extracorporeal liver support.

MARS versus Prometheus – Comparison of two extracorporeal liver support devices

2004 ◽  
Vol 42 (05) ◽  
Author(s):  
V Stadlbauer ◽  
P Krisper ◽  
B Haditsch ◽  
U Beuers ◽  
C Bankuti ◽  
...  
Keyword(s):  
Liver Support ◽  
Extracorporeal Liver Support ◽  
Liver Support Devices ◽  
Support Devices

scholarly journals Extracorporeal liver support devices for listed patients

2016 ◽  
Vol 22 (6) ◽  
pp. 839-848 ◽  
Author(s):  
Karla C. L. Lee ◽  
Vanessa Stadlbauer ◽  
Rajiv Jalan
Keyword(s):  
Liver Support ◽  
Extracorporeal Liver Support ◽  
Liver Support Devices ◽  
Support Devices

Bioartificial liver support devices: historical perspectives

2003 ◽  
Vol 73 (9) ◽  
pp. 739-748 ◽  
Author(s):  
Fiona G. Court ◽  
Simon A. Wemyss-Holden ◽  
Ashley R. Dennison ◽  
Guy J. Maddern
Keyword(s):  
Bioartificial Liver ◽  
Liver Support ◽  
Historical Perspectives ◽  
Bioartificial Liver Support ◽  
Liver Support Devices ◽  
Support Devices

Detoxification Capabilities of Adsorbents for Artificial Liver Support Devices: A Comparison

2014 ◽  
Vol 936 ◽  
pp. 789-794
Author(s):  
Wei Ping Ding ◽  
Li Li Zou ◽  
Ying Ying Pei ◽  
Si Jie Sun ◽  
Da Yong Gao
Keyword(s):  
Activated Carbon ◽  
Adsorption Rate ◽  
Artificial Liver ◽  
Order Kinetic ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Anion Resin ◽  
Adsorption Technology ◽  
Liver Support Devices ◽  
Support Devices

Adsorption performances of activated carbon Norit RO 0.8, neutral resin Amberlite XAD-7, anion resin Dowex 1x4 and cation resin Dowex 50wx4 were investigated in detail for artificial liver support devices. Firstly, equilibrium adsorption experiments of these adsorbents to albumin, creatinine, bilirubin, tryptophan and cholic acid were conducted respectively. Then their adsorption capacities were obtained by curve fitting. The results indicate that activated carbon Norit RO 0.8 and anion resin Dowex 1x4 are two better adsorbents for removing toxins. Lastly, adsorption rate constants of activated carbon Norit RO 0.8 and anion resin Dowex 1x4 to all above solutes were studied with pseudo-first and second-order kinetic adsorption models. The results show that the toxin adsorption rate of anion resin Dowex 1x4 is faster than that of activated carbon Norit RO 0.8. The systematical experimental results in this paper are very important references for researchers in the field of blood purification based on adsorption technology.

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