scholarly journals Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 499 ◽  
Author(s):  
Eric Ke Wang ◽  
Xun Zhang ◽  
Leyun Pan ◽  
Caixia Cheng ◽  
Antonia Dimitrakopoulou-Strauss ◽  
...  
Keyword(s):  
Health Management ◽  
Disease Diagnosis ◽  
Detection Task ◽  
Cell Detection ◽  
Data Sets ◽  
Residual Network ◽  
Nuclei Segmentation ◽  
Nuclei Detection ◽  
Small Targets ◽  
Nuclear Segmentation

As a typical biomedical detection task, nuclei detection has been widely used in human health management, disease diagnosis and other fields. However, the task of cell detection in microscopic images is still challenging because the nuclei are commonly small and dense with many overlapping nuclei in the images. In order to detect nuclei, the most important key step is to segment the cell targets accurately. Based on Mask RCNN model, we designed a multi-path dilated residual network, and realized a network structure to segment and detect dense small objects, and effectively solved the problem of information loss of small objects in deep neural network. The experimental results on two typical nuclear segmentation data sets show that our model has better recognition and segmentation capability for dense small targets.

Review of Metrics and Assignment of Confidence Intervals for Health Management of Gas Turbine Engines

2008 ◽  
Author(s):  
Craig R. Davison ◽  
Jeff W. Bird
Keyword(s):  
Confidence Intervals ◽  
Health Management ◽  
Diagnostic Technique ◽  
Turbine Engines ◽  
Data Sets ◽  
Gas Turbine Engines ◽  
Diagnostic Systems ◽  
Operating Characteristics ◽  
Hypothetical Data ◽  
Test Instance

The development and evaluation of new diagnostic systems requires statistically-based methods to measure performance. Various metrics are in use by developers and users of diagnostic systems. Current metrics practices are reviewed, including receiver operating characteristics, confusion matrices, Kappa coefficients and various entropy techniques. A set of metrics is then proposed for assessment of diverse gas path diagnostic systems. The use of bootstrap statistics to compare metric results is developed, and demonstrated for a set of hypothetical data sets with a range of relevant characteristics. The bootstrap technique allows the expected range of the metric to be assessed without assuming a probability distribution. A method is proposed to develop confidence intervals for the calculated metrics. The application of a confidence interval could prevent a good diagnostic technique being discarded because of a lower value metric in one test instance. The strengths and weaknesses of the various metrics with derived confidence intervals are discussed. Recommendations are made for further work.

scholarly journals Pedestrian detection algorithm based on improved muti-scale feature fusion

2021 ◽  
Vol 2078 (1) ◽  
pp. 012008
Author(s):  
Hui Liu ◽  
Keyang Cheng
Keyword(s):  
Clustering Algorithm ◽  
Feature Fusion ◽  
Pedestrian Detection ◽  
Detection Algorithm ◽  
Data Sets ◽  
False Detection ◽  
Scale Feature ◽  
Multi Scale ◽  
Dilated Convolution ◽  
Small Targets

Abstract Aiming at the problem of false detection and missed detection of small targets and occluded targets in the process of pedestrian detection, a pedestrian detection algorithm based on improved multi-scale feature fusion is proposed. First, for the YOLOv4 multi-scale feature fusion module PANet, which does not consider the interaction relationship between scales, PANet is improved to reduce the semantic gap between scales, and the attention mechanism is introduced to learn the importance of different layers to strengthen feature fusion; then, dilated convolution is introduced. Dilated convolution reduces the problem of information loss during the downsampling process; finally, the K-means clustering algorithm is used to redesign the anchor box and modify the loss function to detect a single category. The experimental results show that the improved pedestrian detection algorithm in the INRIA and WiderPerson data sets under different congestion conditions, the AP reaches 96.83% and 59.67%, respectively. Compared with the pedestrian detection results of the YOLOv4 model, the algorithm improves by 2.41% and 1.03%, respectively. The problem of false detection and missed detection of small targets and occlusion has been significantly improved.

scholarly journals A Dirichlet-Multinomial Bayes Classifier for Disease Diagnosis with Microbial Compositions

mSphere ◽  
2017 ◽  
Vol 2 (6) ◽  
Author(s):  
Xiang Gao ◽  
Huaiying Lin ◽  
Qunfeng Dong
Keyword(s):  
Random Forest ◽  
Classification Accuracy ◽  
Multinomial Distribution ◽  
Disease Diagnosis ◽  
Disease Prevalence ◽  
Data Sets ◽  
Bayes Classifier ◽  
Data Set ◽  
Random Forest Method ◽  
Microbiome Data

ABSTRACT Dysbiosis of microbial communities is associated with various human diseases, raising the possibility of using microbial compositions as biomarkers for disease diagnosis. We have developed a Bayes classifier by modeling microbial compositions with Dirichlet-multinomial distributions, which are widely used to model multicategorical count data with extra variation. The parameters of the Dirichlet-multinomial distributions are estimated from training microbiome data sets based on maximum likelihood. The posterior probability of a microbiome sample belonging to a disease or healthy category is calculated based on Bayes’ theorem, using the likelihood values computed from the estimated Dirichlet-multinomial distribution, as well as a prior probability estimated from the training microbiome data set or previously published information on disease prevalence. When tested on real-world microbiome data sets, our method, called DMBC (for Dirichlet-multinomial Bayes classifier), shows better classification accuracy than the only existing Bayesian microbiome classifier based on a Dirichlet-multinomial mixture model and the popular random forest method. The advantage of DMBC is its built-in automatic feature selection, capable of identifying a subset of microbial taxa with the best classification accuracy between different classes of samples based on cross-validation. This unique ability enables DMBC to maintain and even improve its accuracy at modeling species-level taxa. The R package for DMBC is freely available at https://github.com/qunfengdong/DMBC. IMPORTANCE By incorporating prior information on disease prevalence, Bayes classifiers have the potential to estimate disease probability better than other common machine-learning methods. Thus, it is important to develop Bayes classifiers specifically tailored for microbiome data. Our method shows higher classification accuracy than the only existing Bayesian classifier and the popular random forest method, and thus provides an alternative option for using microbial compositions for disease diagnosis.

scholarly journals An Interpretable Computer-Aided Diagnosis Method for Periodontitis From Panoramic Radiographs

2021 ◽  
Vol 12 ◽  
Author(s):  
Haoyang Li ◽  
Juexiao Zhou ◽  
Yi Zhou ◽  
Qiang Chen ◽  
Yangyang She ◽  
...  
Keyword(s):  
Computational Models ◽  
Alveolar Bone ◽  
Calibration Method ◽  
Disease Diagnosis ◽  
Chronic Inflammatory Disease ◽  
Data Sets ◽  
Data Set ◽  
Panoramic Radiographs ◽  
The Individual ◽  
Severity Degree

Periodontitis is a prevalent and irreversible chronic inflammatory disease both in developed and developing countries, and affects about 20–50% of the global population. The tool for automatically diagnosing periodontitis is highly demanded to screen at-risk people for periodontitis and its early detection could prevent the onset of tooth loss, especially in local communities and health care settings with limited dental professionals. In the medical field, doctors need to understand and trust the decisions made by computational models and developing interpretable models is crucial for disease diagnosis. Based on these considerations, we propose an interpretable method called Deetal-Perio to predict the severity degree of periodontitis in dental panoramic radiographs. In our method, alveolar bone loss (ABL), the clinical hallmark for periodontitis diagnosis, could be interpreted as the key feature. To calculate ABL, we also propose a method for teeth numbering and segmentation. First, Deetal-Perio segments and indexes the individual tooth via Mask R-CNN combined with a novel calibration method. Next, Deetal-Perio segments the contour of the alveolar bone and calculates a ratio for individual tooth to represent ABL. Finally, Deetal-Perio predicts the severity degree of periodontitis given the ratios of all the teeth. The Macro F1-score and accuracy of the periodontitis prediction task in our method reach 0.894 and 0.896, respectively, on Suzhou data set, and 0.820 and 0.824, respectively on Zhongshan data set. The entire architecture could not only outperform state-of-the-art methods and show robustness on two data sets in both periodontitis prediction, and teeth numbering and segmentation tasks, but also be interpretable for doctors to understand the reason why Deetal-Perio works so well.

scholarly journals Bioinformatics: scope and challenges in aquaculture research of Bangladesh- a review

2021 ◽  
Vol 10 (2) ◽  
pp. 137-145
Author(s):  
KMS Rana ◽  
K Ahammad ◽  
MA Salam
Keyword(s):  
Health Management ◽  
National Level ◽  
Work Force ◽  
Disease Diagnosis ◽  
Software Tools ◽  
Biological Data ◽  
Biological Information ◽  
Biological Research ◽  
Future Research ◽  
Data Set

Bioinformatics is one of the ongoing trends of biological research integrating gene based information and computational technology to produce new knowledge. It works to synthesize complex biological information from multiomics data (results of high throughput technologies) by employing a number of bioinformatics tools (software). User convenience and availability are the determining factors of these tools being widely used in bioinformatics research. BLAST, FASTA (FAST-All), EMBOSS, ClustalW, RasMol and Protein Explorer, Cn3D, Swiss PDB viewer, Hex, Vega, Bioeditor etc. are commonly operated bioinformatics software tools in fisheries and aquaculture research. By default, these software tools mine and analyze a vast biological data set using the available databases. However, aquaculture scientists can use bioinformatics for genomic data manipulation, genome annotation and expression profiling, molecular folding, modeling, and design as well as generating biological network and system biology. Therefore, they can contribute in specified fields of aquaculture such as disease diagnosis and aquatic health management, fish nutritional aspects and culture-able strain development. Although having huge prospects, Bangladesh is still in infancy of applying bioinformatics in aquaculture research with limited resources. Research council at national level should be formed to bring all the enthusiastic scientists and skilled manpower under a single umbrella and facilitate to contribute in a collaborative platform. Besides, fully-fledged bioinformatics degree should be launched at University levels to produce knowledgeable and trained work force for future research. This review was attempted to shed light on bioinformatics, as young integrated field of bio-computational research, and its significance in aquaculture research of Bangladesh. Int. J. Agril. Res. Innov. Tech. 10(2): 137-145, December 2020

Modern Health Management With Cognitive Computing and Big Data Analytics

2019 ◽  
pp. 206-224
Author(s):  
Mamata Rath
Keyword(s):  
Big Data ◽  
Data Analytics ◽  
Health Management ◽  
Big Data Analytics ◽  
Large Data ◽  
Data Sets ◽  
Cognitive Computing ◽  
Business Information ◽  
Data Querying ◽  
Data Elements

Big data analytics is an refined advancement for fusion of large data sets that include a collection of data elements to expose hidden prototype, undetected associations, showcase business logic, client inclinations, and other helpful business information. Big data analytics involves challenging techniques to mine and extract relevant data that includes the actions of penetrating a database, effectively mining the data, querying and inspecting data committed to enhance the technical execution of various task segments. The capacity to synthesize a lot of data can enable an association to manage impressive data that can influence the business. In this way, the primary goal of big data analytics is to help business relationship to have enhanced comprehension of data and, subsequently, settle on proficient and educated decisions.

ACO_NB-Based Hybrid Prediction Model for Medical Disease Diagnosis

2021 ◽  
pp. 526-536
Author(s):  
Amit Kumar ◽  
Manish Kumar ◽  
Nidhya R.
Keyword(s):  
Prediction Model ◽  
Disease Diagnosis ◽  
Second Phase ◽  
Data Sets ◽  
Feature Subset ◽  
Hybrid Prediction ◽  
Related Data ◽  
Medical Disease ◽  
Proposed Model ◽  
Two Phases

In recent years, a huge increase in the demand of medically related data is reported. Due to this, research in medical disease diagnosis has emerged as one of the most demanding research domains. The research reported in this chapter is based on developing an ACO (ant colony optimization)-based Bayesian hybrid prediction model for medical disease diagnosis. The proposed model is presented in two phases. In the first phase, the authors deal with feature selection by using the application of a nature-inspired algorithm known as ACO. In the second phase, they use the obtained feature subset as input for the naïve Bayes (NB) classifier for enhancing the classification performances over medical domain data sets. They have considered 12 datasets from different organizations for experimental purpose. The experimental analysis advocates the superiority of the presented model in dealing with medical data for disease prediction and diagnosis.

scholarly journals INTEREST GROUP SESSION—LIFELONG DISABILITIES: DEFINING HEALTH OUTCOMES FOR ADULTS AGING WITH DISABILITY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S352-S352
Author(s):  
Kelly Munly ◽  
Caitlin E Coyle ◽  
Caitlin E Coyle
Keyword(s):  
Cerebral Palsy ◽  
Health Management ◽  
Later Life ◽  
Economic Security ◽  
Data Sets ◽  
Health And Wellness ◽  
Mortality Trends ◽  
Co Morbidity ◽  
Relationship Of

Abstract The population of persons aging with disabilities is growing. Being able to segment aging with disability sub-populations within national data sets is becoming increasingly important in order to understand the relationship of aging with disability to a range of outcomes in later life including health and wellness, economic security, and health and long-term service and support need and use. This symposium includes four examples of how existing data can be used to draw conclusions about the experience of old age for persons with intellectual or developmental disabilities. In addition, the symposium offers insights into the limitations of these data and the presentations lend themselves to a discussion of how measurement across disability sub-population can be ope rationalized. Two of the presentations focus on understanding mortality trends of adults with cerebral palsy and down syndrome--including an understanding of the health conditions facing these populations. A third presentation will focus on cardiovascular risk factors and co morbidity among adults with cerebral palsy. Finally, a fourth presentation will focus on pairing qualitative understanding with quantitative trends to offer a deeper understanding of the health management challenges for adults with disability as they age. Through a deeper understanding of the experience of health in later life for adults with disability, ideas about interventions and supports can be better aligned with the needs of these populations.

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