scholarly journals The Fate of Fusions

Cells ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. 13 ◽  
Author(s):  
Gary Clawson
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Fusion ◽  
Cancer Progression ◽  
Genetic Instability ◽  
Cell Heterogeneity ◽  
Metastatic Dissemination ◽  
Tumor Cell Heterogeneity ◽  
Long Time

The concept of leukocyte-tumor cell fusion as a significant driver of cancer progression has been around a long time, and has garnered growing support over the last several years. The underlying idea seems quite simple and attractive: Fusion of tumor cells (with their inherent genetic instability) with leukocytes, particularly macrophages, could produce hybrids with high invasive capabilities, greatly facilitating their metastatic dissemination, while potentially accelerating tumor cell heterogeneity. While there are a number of attractive features with this story on the surface, the various studies seem to leave us with a conundrum, namely, what is the fate of such fusions?

Microfluidic continuum sorting of sub-populations of tumor cells via surface antibody expression levels

Lab on a Chip ◽  
2017 ◽  
Vol 17 (7) ◽  
pp. 1349-1358 ◽  
Author(s):  
Rhonda Jack ◽  
Khadijah Hussain ◽  
Danika Rodrigues ◽  
Mina Zeinali ◽  
Ebrahim Azizi ◽  
...  
Keyword(s):  
Protein Expression ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Surface Protein ◽  
Cell Heterogeneity ◽  
Expression Levels ◽  
Antibody Expression ◽  
Tumor Cell Heterogeneity ◽  
Surface Protein Expression ◽  
Surface Antibody

In light of the significance of tumor cell heterogeneity, we describe a facile workflow to isolate distinct groups of tumor cells immunomagnetically, according to their surface-protein expression levels.

Epigenomic contributions to tumor cell heterogeneity and plasticity

2021 ◽  
Vol 53 (10) ◽  
pp. 1403-1404
Author(s):  
Radhika Mathur ◽  
Joseph F. Costello
Keyword(s):  
Tumor Cell ◽  
Cell Heterogeneity ◽  
Tumor Cell Heterogeneity

scholarly journals Tumor Microenvironment and Cell Fusion

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Erhui Jiang ◽  
Tinglin Yan ◽  
Zhi Xu ◽  
Zhengjun Shang
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Fusion ◽  
Direct Interaction ◽  
Tumor Stem Cell ◽  
Migration And Invasion ◽  
Future Research ◽  
Microenvironmental Factors ◽  
Cell Cell

Cell fusion is a highly regulated biological process that occurs under both physiological and pathological conditions. The cellular and extracellular environment is critical for the induction of the cell–cell fusion. Aberrant cell fusion is initiated during tumor progression. Tumor microenvironment is a complex dynamic system formed by the interaction between tumor cells and their surrounding cells. Cell–cell fusion mediates direct interaction between tumor cells and their surrounding cells and is associated with tumor initiation and progression. Various microenvironmental factors affect cell fusion in tumor microenvironment and generate hybrids that acquire genomes of both parental cells and exhibit novel characteristics, such as tumor stem cell-like properties, radioresistance, drug resistance, immune evasion, and enhanced migration and invasion abilities, which are closely related to the initiation, invasion, and metastasis of tumor. The phenotypic characteristics of hybrids are based on the phenotypes of parental cells, and the fusion of tumor cells with diverse types of microenvironmental fusogenic cells is concomitant with phenotypic heterogeneity. This review highlights the types of fusogenic cells in tumor microenvironment that can fuse with tumor cells and their specific significance and summarizes the various microenvironmental factors affecting tumor cell fusion. This review may be used as a reference to develop strategies for future research on tumor cell fusion and the exploration of cell fusion-based antitumor therapies.

scholarly journals A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer

Cancer Cell ◽  
2011 ◽  
Vol 19 (2) ◽  
pp. 244-256 ◽  
Author(s):  
Joaquim Calbo ◽  
Erwin van Montfort ◽  
Natalie Proost ◽  
Ellen van Drunen ◽  
H. Berna Beverloo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mouse Model ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Functional Role ◽  
Small Cell ◽  
Cell Heterogeneity ◽  
Small Cell Lung ◽  
Tumor Cell Heterogeneity

scholarly journals Tumor-cell heterogeneity in soft tissue sarcomas as defined by chemoradiotherapy

Cancer ◽  
1984 ◽  
Vol 53 (6) ◽  
pp. 1420-1425 ◽  
Author(s):  
Richard E. Wilson ◽  
Karen H. Antman ◽  
Gilbert Brodsky ◽  
Joel S. Greenberger
Keyword(s):  
Soft Tissue ◽  
Tumor Cell ◽  
Soft Tissue Sarcomas ◽  
Cell Heterogeneity ◽  
Tumor Cell Heterogeneity

Abstract 804: Disseminated tumor cell heterogeneity and dormancy in prostate cancer.

2013 ◽  
Author(s):  
Hung-Ming Lam ◽  
Lisly Chéry ◽  
Ilsa Coleman ◽  
Bryce Lakely ◽  
Sandy Larson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Cell ◽  
Cell Heterogeneity ◽  
Tumor Cell Heterogeneity
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