scholarly journals The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease

Cells ◽  
2016 ◽  
Vol 5 (1) ◽  
pp. 3 ◽  
Author(s):  
Marie Trudel ◽  
Qin Yao ◽  
Feng Qian
Keyword(s):  
Kidney Disease ◽  
G Protein ◽  
Polycystic Kidney Disease ◽  
Renal Physiology ◽  
Polycystic Kidney ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Ankhd1 enhances polycystic kidney disease development via promoting proliferation and fibrosis

2020 ◽  
Author(s):  
Foteini Patera ◽  
Guillaume M Hautbergue ◽  
Patricia Wilson ◽  
Paul C Evans ◽  
Albert CM Ong ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Therapeutic Benefit ◽  
Polycystic Kidney ◽  
Molecular Events ◽  
Proliferative Growth ◽  
Kh Domain ◽  
Autosomal Dominant Polycystic Kidney

ABSTRACTAutosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic kidney disorder resulting in 10% of patients with renal failure. The molecular events responsible for the relentless growth of cysts are not defined. Thus, identification of novel drivers of ADPKD may lead to new therapies. Ankyrin Repeat and Single KH domain-1 (ANKHD1) controls cancer cell proliferation, yet its role in ADPKD is unexplored. Here, we present the first data that identify ANKHD1 as a driver of proliferative growth in cellular and mouse models of ADPKD. Using the first Ankhd1-deficient mice, we demonstrate that Ankhd1 heterozygosity potently reduces cystic growth and fibrosis, in a genetically orthologous mouse model of ADPKD. We performed transcriptome-wide profiling of patient-derived ADPKD cells with and without ANKHD1 siRNA silencing, revealing a major role for ANKHD1 in the control of cell proliferation and matrix remodelling. We validated the role of ANKHD1 in enhancing proliferation in patient-derived cells. Mechanistically ANKHD1 promotes STAT5 signalling in ADPKD mice. Hence, ANKHD1 is a novel driver of ADPKD, and its inhibition may be of therapeutic benefit.

scholarly journals Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor

2012 ◽  
Vol 287 (43) ◽  
pp. 36305-36311 ◽  
Author(s):  
Ka Young Chung ◽  
Tae Hun Kim ◽  
Aashish Manglik ◽  
Rohan Alvares ◽  
Brian K. Kobilka ◽  
...  
Keyword(s):  
G Protein ◽  
Conformational Exchange ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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