scholarly journals Pluripotent Stem Cells for Spinal Cord Injury Repair

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3334
Author(s):  
Maria Martin-Lopez ◽  
Beatriz Fernandez-Muñoz ◽  
Sebastian Canovas
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cell Therapy ◽  
Pluripotent Stem Cells ◽  
Therapeutic Potential ◽  
Cell Types ◽  
Differentiation Potential ◽  
Cell Therapies ◽  
Cord Injury

Spinal cord injury (SCI) is a devastating condition of the central nervous system that strongly reduces the patient’s quality of life and has large financial costs for the healthcare system. Cell therapy has shown considerable therapeutic potential for SCI treatment in different animal models. Although many different cell types have been investigated with the goal of promoting repair and recovery from injury, stem cells appear to be the most promising. Here, we review the experimental approaches that have been carried out with pluripotent stem cells, a cell type that, due to its inherent plasticity, self-renewal, and differentiation potential, represents an attractive source for the development of new cell therapies for SCI. We will focus on several key observations that illustrate the potential of cell therapy for SCI, and we will attempt to draw some conclusions from the studies performed to date.

scholarly journals Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury

2010 ◽  
Vol 107 (28) ◽  
pp. 12704-12709 ◽  
Author(s):  
Osahiko Tsuji ◽  
Kyoko Miura ◽  
Yohei Okada ◽  
Kanehiro Fujiyoshi ◽  
Masahiko Mukaino ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Therapeutic Potential ◽  
Cord Injury ◽  
Induced Pluripotent

Regenerative potential of Stem cell-derived extracellular vesicles in spinal cord injury (SCI)

2021 ◽  
Vol 16 ◽  
Author(s):  
Franklin J Herbert ◽  
Dhivya Bharathi ◽  
Sevanthy Suresh ◽  
Ernest David ◽  
Sanjay Kumar
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Therapy ◽  
Extracellular Vesicles ◽  
Immune Modulation ◽  
Cell Types ◽  
Medical Attention ◽  
Cord Injury

: Spinal cord injury is a devastating condition that is critically challenging and progressive, needing immediate medical attention due to its complex pathophysiology and affecting the social status and economic burden. Stem cell therapy has been the emerging therapeutic trend to treat various diseases for decades. Mesenchymal stem cells pose more advantages over other stem cells in immune-modulation, immune evasiveness, self-renewal, multipotency, etc. Due to various issues in the recent past related to allogenic transplants, ethical concerns in obtaining tissues and adult cells, host immune response, GMP grade production and certification, cell-derived products or cell secretome have proven to be a promising approach and have been implicated in many studies and also in many clinical trials. Utilization of these human MSC-derived exosomes/extracellular vesicles in spinal cord injury has also been demonstrated in many pre-clinical animal models. It is now proven to be therapeutically more efficient and safer than cell therapy. This review focuses on employing human MSC derived EVs for SCI and continues to elucidate the recent advances and emerging EVs trends from other cell types. We discuss biomaterial-based synergistic intervention, mention mimetics and nanovesicles and finally touch upon safety concerns in EV therapy.

scholarly journals Cell therapy for spinal cord injury using induced pluripotent stem cells

2019 ◽  
Vol 11 ◽  
pp. 75-80 ◽  
Author(s):  
Narihito Nagoshi ◽  
Osahiko Tsuji ◽  
Masaya Nakamura ◽  
Hideyuki Okano
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cell Therapy ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Cord Injury ◽  
Induced Pluripotent

Stem Cell Transplantation: A Promising Therapy for Spinal Cord Injury

2020 ◽  
Vol 15 (4) ◽  
pp. 321-331 ◽  
Author(s):  
Zhe Gong ◽  
Kaishun Xia ◽  
Ankai Xu ◽  
Chao Yu ◽  
Chenggui Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Potential ◽  
Embryonic Stem ◽  
Current Status ◽  
Cord Injury

Spinal Cord Injury (SCI) causes irreversible functional loss of the affected population. The incidence of SCI keeps increasing, resulting in huge burden on the society. The pathogenesis of SCI involves neuron death and exotic reaction, which could impede neuron regeneration. In clinic, the limited regenerative capacity of endogenous cells after SCI is a major problem. Recent studies have demonstrated that a variety of stem cells such as induced Pluripotent Stem Cells (iPSCs), Embryonic Stem Cells (ESCs), Mesenchymal Stem Cells (MSCs) and Neural Progenitor Cells (NPCs) /Neural Stem Cells (NSCs) have therapeutic potential for SCI. However, the efficacy and safety of these stem cellbased therapy for SCI remain controversial. In this review, we introduce the pathogenesis of SCI, summarize the current status of the application of these stem cells in SCI repair, and discuss possible mechanisms responsible for functional recovery of SCI after stem cell transplantation. Finally, we highlight several areas for further exploitation of stem cells as a promising regenerative therapy of SCI.

scholarly journals Therapeutic potential of human olfactory bulb neural stem cells for spinal cord injury in rats

Spinal Cord ◽  
2016 ◽  
Vol 54 (10) ◽  
pp. 785-797 ◽  
Author(s):  
H E Marei ◽  
A Althani ◽  
S Rezk ◽  
A Farag ◽  
S Lashen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Olfactory Bulb ◽  
Neural Stem Cells ◽  
Therapeutic Potential ◽  
Cord Injury

Cell therapy of combat related spinal cord injury with use of adult neural crest-derived multipotent stem cells

Cytotherapy ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. S223 ◽  
Author(s):  
V Grytsyk ◽  
A Rodnichenko ◽  
O Gubar ◽  
O Rybachuk ◽  
A Zlatska ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cell Therapy ◽  
Neural Crest ◽  
Multipotent Stem Cells ◽  
Cord Injury
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