scholarly journals Inflammaging, an Imbalanced Immune Response That Needs to Be Restored for Cancer Prevention and Treatment in the Elderly

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2562
Author(s):  
Juana Serrano-López ◽  
Beatriz Martín-Antonio
Keyword(s):  
Immune Response ◽  
Immune Cells ◽  
Public Health System ◽  
Ex Vivo ◽  
Acute Infection ◽  
The Elderly ◽  
Cellular Immunotherapy ◽  
Low Grade ◽  
The Public

Nowadays, new advances in society and health have brought an increased life expectancy. However, at the same time, aging comes with complications that impact the development of autoimmunity, neurodegenerative diseases and cancer. These complications affect the quality of life and impact the public health system. Specifically, with aging, a low-grade chronic sterile systemic inflammation with self-reactivity in the absence of acute infection occurs termed inflammaging. Inflammaging is related to an imbalanced immune response that can be either naturally acquired with aging or accelerated due to external triggers. Different molecules, metabolites and inflammatory forms of cell death are highly involved in these processes. Importantly, adoptive cellular immunotherapy is a modality of treatment for cancer patients that administers ex vivo expanded immune cells in the patient. The manipulation of these cells confers them enhanced proinflammatory properties. A general consequence of proinflammatory events is the development of autoimmune diseases and cancer. Herein, we review subsets of immune cells with a pertinent role in inflammaging,relevant proteins involved in these inflammatory events and external triggers that enhance and accelerate these processes. Moreover, we mention relevant preclinical studies that demonstrate associations of chronic inflammation with cancer development.

scholarly journals Adipocyte, Immune Cells, and miRNA Crosstalk: A Novel Regulator of Metabolic Dysfunction and Obesity

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1004
Author(s):  
Sonia Kiran ◽  
Vijay Kumar ◽  
Santosh Kumar ◽  
Robert L Price ◽  
Udai P. Singh
Keyword(s):  
Insulin Resistance ◽  
Immune Response ◽  
T Cells ◽  
Immune Cells ◽  
Metabolic Diseases ◽  
Liver Disorder ◽  
Low Grade ◽  
Peripheral Tissues ◽  
Nonalcoholic Fatty Liver ◽  
Cytokines And Chemokines

Obesity is characterized as a complex and multifactorial excess accretion of adipose tissue (AT) accompanied with alterations in the immune response that affects virtually all age and socioeconomic groups around the globe. The abnormal accumulation of AT leads to several metabolic diseases, including nonalcoholic fatty liver disorder (NAFLD), low-grade inflammation, type 2 diabetes mellitus (T2DM), cardiovascular disorders (CVDs), and cancer. AT is an endocrine organ composed of adipocytes and immune cells, including B-Cells, T-cells and macrophages. These immune cells secrete various cytokines and chemokines and crosstalk with adipokines to maintain metabolic homeostasis and low-grade chronic inflammation. A novel form of adipokines, microRNA (miRs), is expressed in many developing peripheral tissues, including ATs, T-cells, and macrophages, and modulates the immune response. miRs are essential for insulin resistance, maintaining the tumor microenvironment, and obesity-associated inflammation (OAI). The abnormal regulation of AT, T-cells, and macrophage miRs may change the function of different organs including the pancreas, heart, liver, and skeletal muscle. Since obesity and inflammation are closely associated, the dysregulated expression of miRs in inflammatory adipocytes, T-cells, and macrophages suggest the importance of miRs in OAI. Therefore, in this review article, we have elaborated the role of miRs as epigenetic regulators affecting adipocyte differentiation, immune response, AT browning, adipogenesis, lipid metabolism, insulin resistance (IR), glucose homeostasis, obesity, and metabolic disorders. Further, we will discuss a set of altered miRs as novel biomarkers for metabolic disease progression and therapeutic targets for obesity.

scholarly journals Professional interaction in management of the triad: Permanent Education in Health, patient safety and quality

2020 ◽  
Vol 28 ◽  
Author(s):  
Cintia Koerich ◽  
Alacoque Lorenzini Erdmann ◽  
Gabriela Marcellino de Melo Lanzoni
Keyword(s):  
Patient Safety ◽  
Organizational Structure ◽  
Cultural Change ◽  
Public Health System ◽  
Institutional Culture ◽  
The Public ◽  
Professional Interaction ◽  
Care Processes ◽  
Quality Of Nursing

Objective: to understand how professional interaction takes place in the hospital organizational structure for the management of Permanent Education in Health, to guarantee patient safety and the quality of nursing care. Method: this is a qualitative study, which used the structuralist aspect of the Grounded Theory as a methodological framework. 27 interviewers participated in the study, who made up four sample groups. Results: six categories and 13 subcategories were presented, representing the studied phenomenon and highlighting particularities of the public health system and the influence of the manager’s support and management priority, the disposition of the organizational structure, the institutional culture, the external encouragement to institution, and the nurses’ initiative and leadership in the professional interaction for the management of the Permanent Education in Health, patient safety, and quality of care triad, revealing the need for cultural change through interdisciplinarity. Conclusion: the professional interaction in the hospital organizational structure requires the creation of new management models with an emphasis on more participative management, in order to improve the care processes in hospital institutions.

IMMU-14. REVEALING THE MANY MYELOID STATES IN HUMAN BRAIN TUMORS AND WAYS TO PERTURB THEM

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi94-vi95
Author(s):  
Tyler Miller ◽  
Chadi El Farran ◽  
Julia Verga ◽  
Charles Couturier ◽  
Zeyu Chen ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Microenvironment ◽  
Immune Cells ◽  
Ex Vivo ◽  
Myeloid Cells ◽  
Human Tumor ◽  
Myeloid Cell ◽  
Low Grade ◽  
Tumor Patients ◽  
The Many

Abstract Recent breakthroughs in immunotherapy have revolutionized treatment for many types of cancer, but unfortunately trials of these therapies have failed to provide meaningful life-prolonging benefit for brain tumor patients, potentially due to abundant immunosuppressive myeloid cells in the tumor. Our ultimate goal is to reprogram immunosuppressive tumor associated myeloid cells to an antitumor state to enable effective immunotherapy. Towards this goal, we have deeply characterized the immune microenvironment of more than 50 primary high and low grade gliomas using high-throughput single-cell RNA-sequencing to reveal recurrent myeloid cell states and immunosuppressive programs across IDH1 wild-type and mutant tumors. We have also established a brain tumor organoid model from primary patient tissue that maintains all of the tumor microenvironment, including myeloid and other immune cells. We utilize the this model to functionally test data-driven reprogramming strategies and understand how they impact the states of tumor and immune cells in the ex vivo human tumor microenvironment.

scholarly journals Pain neuroscience education and physical exercise for patients with chronic spinal pain in primary healthcare: a randomised trial protocol

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Miguel A. Galán-Martín ◽  
Federico Montero-Cuadrado ◽  
Enrique Lluch-Girbes ◽  
M. Carmen Coca-López ◽  
Agustín Mayo-Iscar ◽  
...  
Keyword(s):  
Public Health ◽  
Quality Of Life ◽  
Primary Care ◽  
Chronic Pain ◽  
Clinical Practice ◽  
Physical Exercise ◽  
Public Health System ◽  
The Public ◽  
Neuroscience Education

Abstract Background Chronic musculoskeletal pain affects more than 20% of the population, and the prevalence is increasing, causing suffering, loss of quality of life, disability, and an enormous expenditure on healthcare resources. The most common location for chronic pain is the spine. Many of the treatments used are mainly passive (pharmacological and invasive) and poor outcomes. The treatments currently applied in the public health system do not comply with the recommendations of the main clinical practice guidelines, which suggest the use of educational measures and physical exercise as the first-line treatment. A protocol based on active coping strategies is described, which will be evaluated through a clinical trial and which could facilitate the transfer of the recommendations of the clinical practice guidelines to a primary care setting. Methods Randomised and multicentre clinical trials, which will be carried out in 10 Primary Care centres. The trial will compare the effect of a Pain Neuroscience Education program (six sessions, 10 h) and group physical exercise (18 sessions program carried out in six weeks, 18 h), with usual care physiotherapy treatment. Group physical exercise incorporates dual tasks, gaming, and reinforcement of contents of the educational program. The aim is to assess the effect of the intervention on quality of life, as well as on pain, disability, catastrophism, kinesiophobia, central sensitisation, and drug use. The outcome variables will be measured at the beginning of the intervention, after the intervention (week 11), at six months, and a year. Discussion Therapeutic interventions based on active coping strategies are essential for the treatment of chronic pain and the sustainability of the Public Health System. Demonstrating whether group interventions have an effect size is essential for optimising resources in such a prevalent problem. Trial registration NCT03654235 “Retrospectively registered” 31 August 2018.

scholarly journals Seating furniture for public interior (Creating of non-discriminatory interior for people with limitations and seniors)

2013 ◽  
Vol 61 (6) ◽  
pp. 1725-1731
Author(s):  
Věra Kameníková
Keyword(s):  
Public Space ◽  
The Elderly ◽  
Healthy Individuals ◽  
The Public ◽  
Standing Up ◽  
Physical Limitations ◽  
And Function ◽  
Near Future ◽  
Full Utilization

For optimal use and function in the public interior evaluation of seating furniture is important in terms of typology, ergonomics, safety, quality of design, used materials, ecology and other properties. The aim is to adjust the dimensional requirements of the seating furniture for public interior to meet the needs of the current population and reflect the proportional changes in the human body over the last decades.Due to the ageing of population and growing number of people with movement and physiological limitations (which also include the elderly), it will become, in near future, more topical need to modify the rules related to seating furniture that is used in public space. Particularly, in the term of simple and non-discriminatory sitting down and standing up.Proposal to change standards is based on the analysis of used values, the results of the current anthropometrical survey and addition of parameters that were processed by using ergonomic software.In most of the activities related to the seating there is an interaction with the surrounding furniture. Based on this assumption arise the importance of connection between seating furniture and reaching distance of the person sitting on it. Ranges are in the computer simulation divided according to intensity - static, dynamic and comfortable (with the preservation of the natural physiological limitations of joints). The resulting values of simulations can be defined distances suitable for placing objects near seating furniture to ensure the possibility of full utilization.If the principles are kept and they come from the needs of people with limitations, it is certain that the environment will suit all healthy individuals and at the same time it will be non-discriminatory for a greater proportion of people with physical limitations.

scholarly journals The Perception Customers about the Means Quality Infrastructure of Ngantang Public Health Center

2020 ◽  
Vol 4 (1) ◽  
pp. 258-264
Author(s):  
Dwi Ratna ◽  
Sandu Siyoto ◽  
Byba Melda Suhita
Keyword(s):  
Public Health ◽  
Human Resources ◽  
Health Center ◽  
Sampling Technique ◽  
The Elderly ◽  
Persons With Disabilities ◽  
Public Health Center ◽  
The Public ◽  
Customer Perceptions

Background: Ngantang Public Health Center, being a public health center, always tries to apply minimum service standards. Services provided are a form of effort organized to meet community needs. Purpose: The research objective was to explore customer perceptions about the quality of buildings, equipment, human resources at Public Health Center Ngantang. Methodhs: The design used in this research is a qualitative descriptive study with a case study design, which describes customer perceptions about infrastructure; quality of buildings, equipment, human resources at the Public Health Center Ngantang. The sampling technique of this research is purposive sampling technique. The informants in this study consisted of 21 people, namely 5 BPJS PBI, 5 General, 5 Independent BPJS and 6 patient companions as triangulation informants. Data collection techniques using observation, interviews and documentation. Results: The results of the research on customer perceptions about the Public Health Center Ngantang building are the contours of lands prone to landslides, adequate parking facilities, unsafe security facilities, building components and materials are good enough, facilities for persons with disabilities and the elderly are incomplete, consumables are not yet available, furniture is less structured, human resources or labor lack of sympathy and empathy. Conclusion: By conducting this research, it can be used as a reference for Public Health Center Ngantang in improving the quality of infrastructure. consumables are not yet available, water furniture is less structured, human resources or labor lack sympathy and empathy. By conducting this research, it can be used as a reference for Public Health Center Ngantang in improving the quality of infrastructure.

scholarly journals Saúde do idoso, o envelhecimento e as políticas públicas de saúde

2010 ◽  
Vol 1 (1) ◽  
pp. 37
Author(s):  
Thaís Mello de Souza ◽  
Luiz Faustino dos Santos Maia
Keyword(s):  
Public Health ◽  
Quality Of Life ◽  
Health Professionals ◽  
Population Aging ◽  
The Elderly ◽  
The Public ◽  
Calidad De Vida ◽  
The Sixties ◽  
Public Politics

Desde os anos sessenta do século passado, a expressão qualidade de vida tem sido referência de inúmeros discursos acadêmicos, políticos, ideológicos. A preocupação com a saúde do idoso vem promovendo a implantação de políticas públicas de saúde, visando cada vez mais melhoria da qualidade de vida. O envelhecimento populacional é um fenômeno que diz respeito a todos, não ficando circunscrito apenas aos cidadãos maiores de 60 anos. Portanto esta pesquisa através de uma revisão literária objetivou levar ao conhecimento dos profissionais de saúde a cerca da saúde do idoso e as políticas públicas de saúde para este segmento etário. Os resultados mostrou que os profissionais de saúde têm uma grande importância para a melhoria, implementação e execução das políticas públicas de saúde.Descritores: Qualidade de Vida, Saúde do Idoso, Envelhecimento. Health of the aged one, the aging and the public politics of healthAbstractSince the sixties of last century, the term quality of life has been a benchmark for many academic discourses, political, ideological. The concern with the health of the aged one comes promoting the implantation of public politics of health, aiming at each time more improvement of the quality of life. The population aging is a phenomenon that says respect to all, not being circumscribed only to the citizens biggest of 60 years. Therefore this research through a literature review aimed to inform health professionals about the health of the elderly and public health policies for this age group. The results showed that health professionals are of great importance for the improvement, implementation and enforcement of public health policies.OuvirDescriptors:Quality of Life, Health of the Aged one, Aging. Salud Del anciano, el envejecimiento y las politicas publica de saludResumenDesde los años sesenta del siglo pasado, el término calidad de vida ha sido un referente para muchos discursos académicos, políticos, ideológicos. La preocupación por la salud de las personas de edad ha estado promoviendo el despliegue de políticas de salud pública, en busca de mayor calidad y mejores de vida mejor. El envejecimiento poblacional es un fenómeno que concierne a todos, no limitándose sólo a los ciudadanos mayores de 60 años. Por tanto, esta investigación a través de una revisión de la literatura destinada a informar a los profesionales de salud acerca de la salud de las personas mayores y las politicas publicas de salud para este grupo de edad. Los resultados mostraron que los profesionales de la salud son de gran importancia para el mejoramiento, aplicación y ejecución de políticas de salud pública.Descriptores: Calidad de Vida, Salud del Adulto Mayor, Envejecimiento.

scholarly journals Review of evolution of the public long-term care insurance (LTCI) system in different countries: influence and challenge

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Linhong Chen ◽  
Lu Zhang ◽  
Xiaocang Xu
Keyword(s):  
Long Term Care ◽  
The Elderly ◽  
Term Care ◽  
The Public ◽  
Disabled Elderly ◽  
The Disabled ◽  
Long Term Care Insurance ◽  
The Relationship

Abstract Background The growing demand for LTC (Long-term care) services for disabled elderly has become a daunting task for countries worldwide, especially China, where population aging is particularly severe. According to CSY (China Statistical Yearbook,2019), the elderly aged 65 or above has reached 167 million in 2018, and the number of disabled elderly is as high as 54%. Germany and other countries have alleviated the crisis by promoting the public LTCI (Long-Term Care Insurance) system since the 1990s, while China’s public LTCI system formal pilot only started in 2016. Therefore, the development of the public LTCI system has gradually become a hot topic for scholars in various countries, including China. Methods This review has been systematically sorted the existing related literature to discuss the development of public LTCI (Long-Term Care Insurance)system form four aspects, namely, the comparison of public LTCI systems in different countries, the influence of public LTCI, challenge of public LTCI, and the relationship between public LTCI and private LTCI. We searched some databases including Web of Science Core Collection, Medline, SCOPUS, EBSCO, EMBASE, ProQuest and PubMed from January 2008 to September 2020. The quality of 38 quantitative and 21 qualitative articles was evaluated using the CASP(Critical Appraisal Skills Programme) critical evaluation checklist. Results The review systematically examines the development of public LTCI system from four aspects, namely, the comparison of public LTCI systems in different countries, the influence of public LTCI, the challenge of public LTCI, and the relationship between public LTCI and private LTCI. For example, LTCI has a positive effect on the health and life quality of the disabled elderly. However, the role of LTCI in alleviating the financial burden on families with the disabled elderly may be limited. Conclusion Some policy implications on the future development of China’s LTCI system can be obtained. For example, the government should fully consider the constraints such as price rise, the elderly disability rate, and the substantial economic burden. It also can strengthen the effective combination of public LTCI and private LTCI. It does not only help to expand the space for its theoretical research but also to learn the experiences in the practice of the LTCI system in various countries around the world. It will significantly help the smooth development and further promote the in-depth reform of the LTCI system in China.

scholarly journals Effect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 mice

2009 ◽  
Vol 58 (12) ◽  
pp. 1559-1567 ◽  
Author(s):  
Zhihong Ren ◽  
Raina Gay ◽  
Adam Thomas ◽  
Munkyong Pae ◽  
Dayong Wu ◽  
...  
Keyword(s):  
Immune Response ◽  
Ex Vivo ◽  
The Elderly ◽  
Mesenteric Lymph ◽  
Age Related ◽  
Serovar Typhimurium ◽  
Lymph Node Cells ◽  
Old Mice ◽  
Effect Of Age ◽  
Young Mice

Ageing is associated with a decline in immune function, which predisposes the elderly to a higher incidence of infections. Information on the mechanism of the age-related increase in susceptibility to Salmonella enterica serovar Typhimurium (S. Typhimurium) is limited. In particular, little is known regarding the involvement of the immune response in this age-related change. We employed streptomycin (Sm)-pretreated C57BL/6 mice to develop a mouse model that would demonstrate age-related differences in susceptibility and immune response to S. Typhimurium. In this model, old mice inoculated orally with doses of 3×108 or 1×106 c.f.u. S. Typhimurium had significantly greater S. Typhimurium colonization in the ileum, colon, Peyer's patches, spleen and liver than young mice. Old mice had significantly higher weight loss than young mice on days 1 and 2 post-infection. In response to S. Typhimurium infection, old mice failed to increase ex vivo production of IFN-γ and TNF-α in the spleen and mesenteric lymph node cells to the same degree as observed in young mice; this was associated with their inability to maintain the presence of neutrophils and macrophages at a ‘youthful’ level. These results indicate that Sm-pretreated C57BL/6 old mice are more susceptible to S. Typhimurium infection than young mice, which might be due to impaired IFN-γ and TNF-α production as well as a corresponding change in the number of neutrophils and macrophages in response to S. Typhimurium infection compared to young mice.

scholarly journals Quality of Life of Patients with early Onset Dementia in Nigeria

2013 ◽  
Vol 12 ◽  
pp. 28-42
Author(s):  
Elias Olukorede Wahab ◽  
Chioma Joan Ikebudu
Keyword(s):  
Cognitive Abilities ◽  
Early Onset ◽  
The Elderly ◽  
Health Impact ◽  
Early Onset Dementia ◽  
The Public ◽  
Interview Research ◽  
Dementia Prevention ◽  
Key Informant Interview

Dementia is a major cause of disability and mortality among the elderly, it becomes early onset of dementia, when it occurs before the age of 60 years. It is the loss of cognitive abilities, particularly the loss of memory; it appears to be one of the most dreaded conditions of old age. Around 5% of the population aged 65 and above is affected by dementia, and its prevalence rises with the rate nearly doubling every 5 years. The study used the key informant interview research tool to achieve its aim and objectives, thereby collecting data to answer its research questions. Purposive sampling was used, while ethnographic summary was used to analyse the data. The results of the study showed that the quality of patients with early onset of dementia is generally poor, in that the illness brings about the crippling of finance, loss of memory and independence, loss of position in the society. The study recommends detecting factors that can prevent or postpone the disease, and educating the public on early onset of dementia (OED). Interventions that could delay early onset of dementia would have a major positive public health impact and the prospect of dementia prevention may also reduce some of the common fears and anxieties of becoming older.

Sign in / Sign up

Export Citation Format

Share Document