scholarly journals Exercise and Sestrin Mediate Speed and Lysosomal Activity in Drosophila by Partially Overlapping Mechanisms

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2479
Author(s):  
Alyson Sujkowski ◽  
Robert Wessells
Keyword(s):  
Animal Models ◽  
Endurance Exercise ◽  
Critical Factor ◽  
Chronic Exercise ◽  
Key Factors ◽  
Lysosomal Activity ◽  
Evolutionarily Conserved ◽  
Physiological Adaptations ◽  
The Impact

Chronic exercise is widely recognized as an important contributor to healthspan in humans and in diverse animal models. Recently, we have demonstrated that Sestrins, a family of evolutionarily conserved exercise-inducible proteins, are critical mediators of exercise benefits in flies and mice. Knockout of Sestrins prevents exercise adaptations to endurance and flight in Drosophila, and similarly prevents benefits to endurance and metabolism in exercising mice. In contrast, overexpression of dSestrin in muscle mimics several of the molecular and physiological adaptations characteristic of endurance exercise. Here, we extend those observations to examine the impact of dSestrin on preserving speed and increasing lysosomal activity. We find that dSestrin is a critical factor driving exercise adaptations to climbing speed, but is not absolutely required for exercise to increase lysosomal activity in Drosophila. The role of Sestrin in increasing speed during chronic exercise requires both the TORC2/AKT axis and the PGC1⍺ homolog spargel, while dSestrin requires interactions with TORC1 to cell-autonomously increase lysosomal activity. These results highlight the conserved role of Sestrins as key factors that drive diverse physiological adaptations conferred by chronic exercise.

scholarly journals What Kept the Boat Afloat? Sustainability of Employment in Knowledge-Intensive Sectors Due to Government Measures during COVID-19 Pandemic

2021 ◽  
Vol 13 (15) ◽  
pp. 8441
Author(s):  
Michal Hrivnák ◽  
Peter Moritz ◽  
Marcela Chreneková
Keyword(s):  
Key Factors ◽  
Economic Shocks ◽  
Management Tools ◽  
Employment Retention ◽  
State Compensation ◽  
Business Resilience ◽  
Knowledge Intensive ◽  
Econometric Approach ◽  
The Impact

The COVID-19 pandemic has exposed new aspects of sustainable entrepreneurship and the resilience of SMEs in the conditions of individual countries. This empirical study contributes to entrepreneurship sustainability literature and business resilience literature by estimating the impact of various utilized internal crisis management tools and state compensation measures on retaining the pre-crisis levels of employment after two waves of the pandemic on the conditions of a V4 country. The study adopts an econometric approach towards assessing the influence of key factors of mitigating the problems caused by the pandemic, and the results suggest a crucial role of digitalization, internal policies optimizing variable costs, and utilization of direct governmental supportive measures to compensate for restrictions in force for employment retention in knowledge-intensive SMEs. According to the results, knowledge-intensive SMEs appears to have increased resilience towards economic shocks due to the capability to swiftly change the management of ventures to adapt to a crisis.

scholarly journals Collaboration, Mentoring and Co-Teaching in Teacher Education

2011 ◽  
Vol 13 (2) ◽  
pp. 70-86 ◽  
Author(s):  
Gertrude Sachs ◽  
Terry Fisher ◽  
Joanna Cannon
Keyword(s):  
Teacher Education ◽  
Doctoral Students ◽  
Junior Faculty ◽  
Key Factors ◽  
Collaborative Relationships ◽  
The University ◽  
The Impact ◽  
Individual Accountability

Collaboration, Mentoring and Co-Teaching in Teacher EducationCollaboration at the university level is a fundamental element needed to enhance teaching (Cochran-Smith & Fries, 2005) and reflection is a critical component of teacher education (Dewey, 1933, 1938). A case study is presented of one senior university faculty member's experiences co-teaching with two doctoral students seeking to understand the impact of shared decision-making and authentic collaboration on individuals entering the academy. An analysis of the authors' shared experiences indicated that, through this mentoring, collaborative and mutually beneficial relationships were built. An analysis of the authors' experiences also indicated that these collaborative relationships were built upon several key factors, specifically (a) a strong sense of individual accountability and professionalism; (b) the mutual creation and demonstration of respect; (c) affirmation and overt participation in reciprocal growth and development; (d) attention to issues of power and abeyance. The findings of the study highlight the need for further exploration into the role of mentorship of junior faculty and the efficacy of co-teaching processes in the development of professional identities of junior faculty entering the academy.

scholarly journals NEW ZEALAND HORTICULTURAL EXPORTS

HortScience ◽  
1992 ◽  
Vol 27 (6) ◽  
pp. 589a-589
Author(s):  
D. H. Turner
Keyword(s):  
New Zealand ◽  
Tertiary Education ◽  
Marketing Strategies ◽  
Key Factors ◽  
Marketing Technology ◽  
The Past ◽  
Export Expansion ◽  
Future 2 ◽  
The Impact

New Zealand horticultural exports expanded rapidly during 1970-1990. These increases did not occur without some difficulties. Details of the export expansion including main products and major markets (such as the U. S. and Pacific Rim Countries) will be discussed. Key factors such as: 1) marketing strategies of the past, present, and future; 2) the impact of new marketing technology; and 3) importance of New Zealand image will be detailed. The role of education and technology and the skill level of New Zealand horticulture will be reviewed. This will include the New Zealand tertiary education system as well as relevant examples of how universities can assist.

scholarly journals The Possible Role Of Toll-Like Receptor 4 In The Pathology Of Stroke

2017 ◽  
pp. 8
Author(s):  
Mohammad Allahtavakoli ◽  
Ali Shamsizadeh ◽  
Ali Roohbakhsh ◽  
Amir Moghadam-Ahmadi ◽  
Mohammad Reza Rahmani ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Inflammatory Response ◽  
System Response ◽  
Toll Like Receptor ◽  
Key Factors ◽  
Toll Like Receptor 4 ◽  
Brain Functions ◽  
Essential Components ◽  
The Impact

Stroke is a prevalent and dangerous health problem, which triggers an intense inflammatory response to Toll-like receptors (TLRs) activation. TLRs are the essential components of innate immunity system response, and therefore, they are one of the key factors involved in recognizing pathogens and internal ligands. Among TLRs, TLR4 significantly participates in the induction of inflammation and brain functions, hence, it has been hypothesized that this molecule is associated with several brain immune-related diseases such as stroke. It has also been proved that animals with TLR4 deficiency have higher protection against ischemia and the absence of TLR4 reduces the neuroinflammation and injuries associated with brain trauma. TLR4 deficiency may play a neuroprotective role in the occurrence of stroke. This article will review recent information regarding the impact of TLR4 in the pathogenicity of stroke.

scholarly journals Stent strut streamlining and thickness reduction promote endothelialization

2021 ◽  
Vol 18 (181) ◽  
pp. 20210023
Author(s):  
Duy T. Nguyen ◽  
Alexander F. Smith ◽  
Juan M. Jiménez
Keyword(s):  
Stent Thrombosis ◽  
Critical Factor ◽  
Prognostic Indicator ◽  
Dependent Manner ◽  
Wound Healing Assay ◽  
Strut Thickness ◽  
Stent Strut ◽  
Static Conditions ◽  
The Impact

Stent thrombosis (ST) carries a high risk of myocardial infarction and death. Lack of endothelial coverage is an important prognostic indicator of ST after stenting. While stent strut thickness is a critical factor in ST, a mechanistic understanding of its effect is limited and the role of haemodynamics is unclear. Endothelialization was tested using a wound-healing assay and five different stent strut models ranging in height between 50 and 150 µm for circular arc (CA) and rectangular (RT) geometries and a control without struts. Under static conditions, all stent strut surfaces were completely endothelialized. Reversing pulsatile disturbed flow caused full endothelialization, except for the stent strut surfaces of the 100 and 150 µm RT geometries, while fully antegrade pulsatile undisturbed flow with a higher mean wall shear stress caused only the control and the 50 µm CA geometries to be fully endothelialized. Modest streamlining and decrease in height of the stent struts improved endothelial coverage of the peri-strut and stent strut surfaces in a haemodynamics dependent manner. This study highlights the impact of the stent strut height (thickness) and geometry (shape) on the local haemodynamics, modulating reendothelialization after stenting, an important factor in reducing the risk of stent thrombosis.

Geographies of the Protestant Reformation

2015 ◽  
Author(s):  
Graeme Murdock
Keyword(s):  
Protestant Reformation ◽  
Key Factors ◽  
Shared Space ◽  
Spatial Imagination ◽  
The Impact ◽  
The Relationship

This chapter considers the dynamic geography of Protestant Europe. It analyzes attempts to map the impact of Protestantism across the Continent, highlighting the difficulty of presenting any sort of reliable depiction of the complex ways in which Protestant and Catholic societies divided and shared space in Europe. It examines the relationship between Protestant confessional frontiers and state borders. It also considers key factors that help to explain the spread and extent of Protestantism focusing on the role of towns and of linguistic affinity. It concludes by referencing a text on traveling across Europe on the outbreak of the Thirty Years War to reflect on the spatial imagination of Protestants.

scholarly journals Corporate entrepreneurship and financial performance: The role of management

2002 ◽  
Vol 33 (4) ◽  
pp. 21-27 ◽  
Author(s):  
C. J. Goosen ◽  
T. J. De Coning ◽  
E. V.D.M. Smit
Keyword(s):  
Financial Performance ◽  
Positive Relationship ◽  
Stock Exchange ◽  
Corporate Entrepreneurship ◽  
Industrial Sector ◽  
Key Factors ◽  
Financial Outcomes ◽  
Johannesburg Stock Exchange ◽  
The Impact

It is hypothesised that a positive relationship exists between the financial performance of an organisation and the level of intrapreneurship within the organisation with causation running from entrepreneurship to financial outcomes. Using a three-factor key intrapreneurship model developed by Goosen, De Coning and Smit (2002) and financial outcomes from a sample of companies listed in the industrial sector of the Johannesburg Stock Exchange, this proposition is put to the test. The results support the hypothesis that the key factors innovativeness, proactiveness and management’s internal influence all significantly contribute to financial performance if regarded individually, but that the last factor dominates the first two external factors when used simultaneously. The conclusion underscores the importance of the impact of leadership on financial outcomes.

scholarly journals THE ROLE OF INNOVATIVE ENTREPRENEURSHIP IN ECONOMIC DEVELOPMENT: A CASE OF G20 COUNTRIES

2021 ◽  
pp. 6-14
Author(s):  
Fayzullokh Sattoriy ◽  
Behzod Abdupaizov
Keyword(s):  
Economic Growth ◽  
Economic Development ◽  
Growing Up ◽  
Key Factors ◽  
Growth And Survival ◽  
Innovative Firms ◽  
The Impact ◽  
Innovation And Entrepreneurship

Innovation and entrepreneurship are considered key factors of growth and survival of modern economies. According to Schumpeter (1934), “carrying out innovations is the only function which is fundamental in history". The review of recent studies reveals that high levels of newly growing up innovative firms are strongly related to economic growth (Stam, 2008).The vinculum of innovation, entrepreneurship and economic development is a matter of great interest at the present time. Given this context, the aim of this study is to explore the relation of Innovative Entrepreneurship and economic growth and its role in economic development of G20 member countries. For this, an overview of literature regarding the impact of innovation and entrepreneurship on economic development is discussed. KEYWORDS: Entrepreneurship, Innovation, Economic Development, SMEs, G20 Countries

Humanitarian Negotiation with Parties to Armed Conflict

2020 ◽  
Vol 11 (1) ◽  
pp. 68-96
Author(s):  
Rob Grace
Keyword(s):  
Armed Conflict ◽  
Final Section ◽  
International Humanitarian Law ◽  
Humanitarian Law ◽  
Key Factors ◽  
Structured Interviews ◽  
Negotiation Processes ◽  
Two Factors ◽  
The Impact

This article examines the role of international humanitarian law (ihl) and humanitarian principles in the discourse of humanitarian negotiation. The article is based on extensive, semi-structured interviews conducted with 53 humanitarian practitioners about their experiences engaging in negotiations in the field. The article proceeds in four parts. Part 1 discusses two key factors at play during humanitarian negotiation processes. The first factor is the counterpart’s familiarity with relevant legal and normative frameworks. The second factor is the interests that can drive counterparts’ behavior. Part 2 presents a framework for understanding how the interaction of these two factors – familiarity and interest-alignment – can shape the discourse of humanitarian negotiation. Part 3 addresses the impact of these same issues on the humanitarian side of the negotiation. In particular, there is the possibility that humanitarian actors themselves might also lack familiarity with ihl and/or humanitarian principles and might find that their interests exist in tension with humanitarian laws and principles. The final section offers concluding remarks.

Bacteriocins: antibiotics in the age of the microbiome

2017 ◽  
Vol 1 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Kevin Egan ◽  
R. Paul Ross ◽  
Colin Hill
Keyword(s):  
Infectious Disease ◽  
Animal Models ◽  
Antimicrobial Resistance ◽  
Animal Health ◽  
Collateral Damage ◽  
Safety And Efficacy ◽  
Antibiotic Development ◽  
The Impact ◽  
Activity Animal

Antibiotics have revolutionised the treatment of infectious disease and improved the lives of billions of people worldwide over many decades. With the rise in antimicrobial resistance (AMR) and corresponding lack of antibiotic development, we find ourselves in dire need of alternative treatments. Bacteriocins are a class of bacterially produced, ribosomally synthesised, antimicrobial peptides that may be narrow or broad in their spectra of activity. Animal models have demonstrated the safety and efficacy of bacteriocins in treating a broad range of infections; however, one of the principal drawbacks has been their relatively narrow spectra when compared with small-molecule antibiotics. In an era where we are beginning to appreciate the role of the microbiota in human and animal health, the fact that bacteriocins cause much less collateral damage to the host microbiome makes them a highly desirable therapeutic. This review makes a case for the implementation of bacteriocins as therapeutic antimicrobials, either alone or in combination with existing antibiotics to alleviate the AMR crisis and to lessen the impact of antibiotics on the host microbiome.

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