scholarly journals Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1768
Author(s):  
Elżbieta Wieczorek ◽  
Andrzej Ożyhar
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Cardiovascular Diseases ◽  
Environmental Factors ◽  
Blood Coagulation ◽  
Structural Stability ◽  
Nutrition Status ◽  
Tissue Calcification ◽  
Amyloid Deposits ◽  
And Oxidative Stress

Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain, which has many other activities that have not been fully acknowledged. TTR is a positive indicator of nutrition status and is negatively correlated with inflammation. TTR is a neuroprotective and oxidative-stress-suppressing factor. The TTR structure is destabilized by mutations, oxidative modifications, aging, proteolysis, and metal cations, including Ca2+. Destabilized TTR molecules form amyloid deposits, resulting in senile and familial amyloidopathies. This review links structural stability of TTR with the environmental factors, particularly oxidative stress and Ca2+, and the processes involved in the pathogenesis of TTR-related diseases. The roles of TTR in biomineralization, calcification, and osteoarticular and cardiovascular diseases are broadly discussed. The association of TTR-related diseases and vascular and ligament tissue calcification with TTR levels and TTR structure is presented. It is indicated that unaggregated TTR and TTR amyloid are bound by vicious cycles, and that TTR may have an as yet undetermined role(s) at the crossroads of calcification, blood coagulation, and immune response.

scholarly journals Effects of pyrene exposure on immune response and oxidative stress in the pearl oyster, Pinctada martensii

2017 ◽  
Vol 63 ◽  
pp. 237-244 ◽  
Author(s):  
Jia Xie ◽  
Chunfeng Zhao ◽  
Qian Han ◽  
Hailong Zhou ◽  
Qingxiao Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Pearl Oyster ◽  
Pinctada Martensii ◽  
And Oxidative Stress

Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms

2015 ◽  
Vol 129 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Andreia Z. Chignalia ◽  
Maria Aparecida Oliveira ◽  
Victor Debbas ◽  
Randal O. Dull ◽  
Francisco R.M. Laurindo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Nadph Oxidase ◽  
Vascular Disease ◽  
Leucocyte Migration ◽  
And Oxidative Stress

Testosterone triggers leucocyte migration and oxidative stress, important features in inflammation and in the development of cardiovascular diseases. The mechanisms by which testosterone increase cardiovascular risk are unknown. We describe one pathway whereby testosterone can potentially contribute to vascular disease.

scholarly journals Autophagy and oxidative stress in cardiovascular diseases

2015 ◽  
Vol 1852 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Yu Mei ◽  
Melissa D. Thompson ◽  
Richard A. Cohen ◽  
XiaoYong Tong
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
And Oxidative Stress

scholarly journals Review of polymorphisms, associated with cardiovascular diseases

2021 ◽  
pp. 333-338
Author(s):  
A. A. Akopyan ◽  
I. D. Strazhesko ◽  
O. N. Tkacheva ◽  
A. P. Yesakova ◽  
I. A. Orlova
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cardiovascular Diseases ◽  
Chronic Inflammation ◽  
Gene Polymorphisms ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
System Activation ◽  
And Oxidative Stress

In this research we examined studies of gene polymorphisms, associated with cardiovascular diseases through renin-angiotensin-aldosterone system activation (AGT с.521С>Т, AСE Ins>Del), nitric oxide decline (NOS3 с.894G>T), chronic inflammation (TNF -238G>A, MMP9 -1562С>T) and oxidative stress (CYBA c.214Т>С).

scholarly journals Biochemical and immunological investigation of fascioliasis in cattle in Egypt

2020 ◽  
Vol 13 (5) ◽  
pp. 923-930
Author(s):  
Nani Nasreldin ◽  
Rania Samir Zaki
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Meat Quality ◽  
Stress Factors ◽  
Postmortem Changes ◽  
Immunological Parameters ◽  
Serum Biochemical ◽  
Fasciola Spp ◽  
Glutamyl Transferase ◽  
And Oxidative Stress

Background and Aim: Fasciola hepatica and Fasciola gigantica are two commonly reported liver flukes that cause fascioliasis in ruminants. Among the members of the genus Fasciola, F. hepatica was identified in the study area. Fascioliasis is a major disease that affects the production of livestock by causing liver damage. F. hepatica has developed advanced mechanisms to trick, elude, and alter the host immune response, similar to an extrinsic stressor. These mechanisms consequently affect the animals' physiological and metabolic functions in vivo and postmortem changes, which have significant influences on animal welfare and meat quality development. Therefore, this study aimed to determine the current prevalence of cattle fascioliasis at abattoirs in El-Kharga city, New Valley Governorate, Egypt, and to investigate the changes in serum biochemical and immunological parameters and oxidative stress factors due to Fasciola spp. infection in terms of meat quality and immune response. Materials and Methods: A total of 226 cattle were inspected for the presence of Fasciola spp. The liver of each cattle was examined by making several incisions for detecting adult Fasciola spp. in El- Kharga . The blood samples were collected to analyze the changes in serum biochemical and immunological parameters and oxidative stress factors. Results: Of the 226 cattle, 38 (16.81%) were positive for F. hepatica at the postmortem examination. Cattle infected with F. hepatica had highly elevated serum alanine aminotransferase, aspartate aminotransferase, glutamate dehydrogenase, γ-glutamyl transferase, urea, and creatinine levels. Immunological cytokine profiles showed significantly increased serum interleukin (IL)-4, IL-10, and transforming growth factor-beta levels and a significantly decreased interferon-γ level. Furthermore, oxidative stress profiles showed significantly increased serum malondialdehyde and nitric oxide levels and significantly decreased total antioxidant capacity and reduced glutathione level. Conclusion: This study demonstrated that F. hepatica infection alone is an oxidative stress factor that affects slaughtered animals, leading to biochemical and metabolic alterations in the early postmortem period.

scholarly journals Effect of COVID-19 Infection on the Immune System and Risk of Developing Diabetes Complications: A Review

2020 ◽  
Author(s):  
Samir Derouiche ◽  
Cheradid Taissir ◽  
Djoumana Abdelmalek ◽  
Ikram Achi
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Immune System ◽  
Diabetes Complications ◽  
Vascular Complications ◽  
Health Concern ◽  
Diabetic Patients ◽  
Global Public Health ◽  
Chronic Hyperglycemia ◽  
And Oxidative Stress

Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. The pandemic outbreak of COVID-19 is rapidly spreading all over the world. In this review, we try to summarize studies of the relationship between the alteration of immune system during COVID-19 infection and the risk of developing diabetes complications. The data were collected by searching Science Direct, Google Scholar, PubMed, Scopus, Springer and National Center for Biotechnology Information (NCBI). The Keywords used as search terms were “COVID-19”, “SARS-COV2 induced inflammatory reaction”, “ACE2 and COVID-19 infection”, “Diabetes and Oxidative stress” and “COVID-19 induced Diabetes complication”. The risk of COVID-19 infection in patients is due to the severity of the viral infection and also to the host's immune response. The risk of infection is one of the main complications of diabetics, as it has been suggested that diabetes inhibits the immune response which contributes to infection and progression to symptoms. Also, the evidence of generation of oxygen free radicals and oxidative stress is a key process in the onset of diabetes mellitus which participate in the development of the systemic inflammatory response syndrome. In addition, chronic hyperglycemia during COVID-19 infection may increase the release of inflammatory cytokines, a high ability to bind to the virus ACE2 glycosylated, worsen the ketoacidosis and vascular complications that may explain the severity of the SARS-CoV-2 infection in diabetic patients.

Immune Response and Oxidative Stress in Obesity-Induced Cancer

2021 ◽  
pp. 109-128
Author(s):  
Pradip Kumar Jaiswara ◽  
Pratishtha Sonker ◽  
Ajay Kumar
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
And Oxidative Stress

scholarly journals Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?

2013 ◽  
Vol 140 (3) ◽  
pp. 239-257 ◽  
Author(s):  
Luc Rochette ◽  
Julie Lorin ◽  
Marianne Zeller ◽  
Jean-Claude Guilland ◽  
Luc Lorgis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cardiovascular Diseases ◽  
Nitric Oxide Synthase ◽  
Therapeutic Targets ◽  
Oxide Synthase ◽  
And Oxidative Stress
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