scholarly journals Microtubule-Associated Protein ATIP3, an Emerging Target for Personalized Medicine in Breast Cancer

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1080
Author(s):  
Maria M. Haykal ◽  
Sylvie Rodrigues-Ferreira ◽  
Clara Nahmias
Keyword(s):  
Breast Cancer ◽  
Prognostic Biomarker ◽  
Breast Tumors ◽  
Predictive Biomarker ◽  
Suppressor Gene ◽  
Molecular Characteristics ◽  
New Era ◽  
Candidate Tumor Suppressor Gene ◽  
Therapeutic Decisions ◽  
Anti Cancer

Breast cancer is the leading cause of death by malignancy among women worldwide. Clinical data and molecular characteristics of breast tumors are essential to guide clinician’s therapeutic decisions. In the new era of precision medicine, that aims at personalizing the treatment for each patient, there is urgent need to identify robust companion biomarkers for new targeted therapies. This review focuses on ATIP3, a potent anti-cancer protein encoded by candidate tumor suppressor gene MTUS1, whose expression levels are markedly down-regulated in breast cancer. ATIP3 is a microtubule-associated protein identified both as a prognostic biomarker of patient survival and a predictive biomarker of breast tumors response to taxane-based chemotherapy. We present here recent studies pointing out ATIP3 as an emerging anti-cancer protein and a potential companion biomarker to be combined with future personalized therapy against ATIP3-deficient breast cancer.

scholarly journals CDKN1C/p57kip2is a candidate tumor suppressor gene in human breast cancer

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Pamela S Larson ◽  
Benjamin L Schlechter ◽  
Chia-Lin King ◽  
Qiong Yang ◽  
Chelsea N Glass ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Human Breast Cancer ◽  
Suppressor Gene ◽  
Human Breast ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

scholarly journals Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer

Oncogene ◽  
1998 ◽  
Vol 16 (16) ◽  
pp. 2159-2164 ◽  
Author(s):  
Hiroaki Fujii ◽  
Margaret A Biel ◽  
Weibo Zhou ◽  
Sigmund A Weitzman ◽  
Stephen B Baylin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Human Breast Cancer ◽  
Suppressor Gene ◽  
Human Breast ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

scholarly journals Autoantibody Response to ZRF1 and KRR1 SEREX Antigens in Patients with Breast Tumors of Different Histological Types and Grades

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Lada Dyachenko ◽  
Kristina Havrysh ◽  
Anita Lytovchenko ◽  
Irina Dosenko ◽  
Stepan Antoniuk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antibody Response ◽  
Cancer Patients ◽  
Breast Tumors ◽  
Cancer Diagnostics ◽  
Protein Isoforms ◽  
Enzyme Linked Immunosorbent Assay ◽  
Molecular Characteristics ◽  
Breast Cancer Patients ◽  
Histological Types

Purpose. To investigate a frequency of antibody response to SEREX-identified medullary breast carcinoma autoantigens ZRF1 and KRR1 in sera of breast cancer patients taking into account clinical and molecular characteristics of tumors for opening of new perspectives in creation of minimally invasive immunological tests for cancer diagnostics. Methods. Enzyme-linked immunosorbent assay and bioinformatics analysis. Results. Increased frequency of antibody response was found in sera of breast cancer patients to ZRF and KRR1 antigens. The antibody response to these antigens was higher in sera of patients with invasive ductal carcinoma than in sera of patients with other histological types of breast tumors. Moreover, more frequent antibody response to ZRF antigen was found in sera of patients with less aggressive tumors. The sequence analysis of ZRF1 antigen SEREX clones obtained from cDNA libraries of different tumors demonstrates that they encode different protein isoforms. Conclusion. Tumor-associated antigens KRR1 and ZRF1 and their cognate autoantibodies could be considered as potential molecular markers of breast cancer which need to be further investigated.

scholarly journals Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer

2007 ◽  
Vol 121 (3) ◽  
pp. 547-554 ◽  
Author(s):  
Beatrix Versmold ◽  
Jörg Felsberg ◽  
Thomas Mikeska ◽  
Denise Ehrentraut ◽  
Juliane Köhler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Sporadic Breast Cancer ◽  
Suppressor Gene ◽  
Epigenetic Silencing ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

scholarly journals Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk

2007 ◽  
Vol 28 (7) ◽  
pp. 1442-1445 ◽  
Author(s):  
Bernd Frank ◽  
Justo Lorenzo Bermejo ◽  
Kari Hemminki ◽  
Christian Sutter ◽  
Barbara Wappenschmidt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Tumor Suppressor ◽  
Cancer Risk ◽  
Copy Number ◽  
Familial Breast Cancer ◽  
Copy Number Variant ◽  
Suppressor Gene ◽  
Candidate Tumor Suppressor Gene ◽  
Familial Breast Cancer Risk

Complex CGH alterations on chromosome arm 8p at candidate tumor suppressor gene loci in breast cancer cell lines

2005 ◽  
Vol 160 (2) ◽  
pp. 134-140 ◽  
Author(s):  
Deon J. Venter ◽  
Susan J. Ramus ◽  
Fleur M.A. Hammet ◽  
Melanie de Silva ◽  
Anne-Marie Hutchins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Suppressor Gene ◽  
Breast Cancer Cell Lines ◽  
Candidate Tumor Suppressor Gene ◽  
Chromosome Arm
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