scholarly journals Analysis of Circulating microRNA Signatures and Preeclampsia Development

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1003
Author(s):  
Margarita L. Martinez-Fierro ◽  
Idalia Garza-Veloz
Keyword(s):  
Pregnant Women ◽  
Expression Profiling ◽  
Gene Prediction ◽  
Microrna Expression ◽  
Differentially Expressed ◽  
Control Group ◽  
Case Group ◽  
Circulating Microrna ◽  
Activated T Cells ◽  
Serum Microrna

microRNAs are important regulators of cell processes and have been proposed as potential preeclampsia biomarkers. We evaluated serum microRNA expression profiling to identify microRNAs involved in preeclampsia development. Serum microRNA expression profiling was evaluated at 12, 16, and 20 weeks of gestation (WG), and at the time of preeclampsia diagnosis. Two groups were evaluated using TaqMan low-density array plates: a control group with 18 normotensive pregnant women and a case group with 16 patients who developed preeclampsia during the follow-up period. Fifty-three circulating microRNAs were differentially expressed between groups (p < 0.05). Compared with controls, hsa-miR-628-3p showed the highest relative quantity values (at 12 WG = 7.7 and at 20 WG = 3.45) and the hsa-miRs -151a-3p and -573 remained differentially expressed from 16 to 20 WG (p < 0.05). Signaling pathways including cancer-related, axon guidance, Neurotrophin, GnRH, VEGF, and B/T cell receptor, were most commonly altered. Further target gene prediction revealed that nuclear factor of activated T-cells 5 gene was included among the transcriptional targets of preeclampsia-modulated microRNAs. Specific microRNAs including hsa-miRs -628-3p, -151a-3p, and -573 were differentially expressed in serum of pregnant women before they developed preeclampsia compared with controls and their participation in the preeclampsia development should be considered.

scholarly journals The Predictive Value of the Mother’s Risk Factors in Formation of Fetal Developmental Delay

2021 ◽  
Vol 8 ◽  
pp. 2333794X2199914
Author(s):  
Maka Chigladze
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Predictive Value ◽  
Negative Impact ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Retrospective Case ◽  
Standards Of Living ◽  
Poor Nutrition

The research aimed at studying the mother’s social-hygienic and medical biological risk factors and determining their predictive value. The retrospective case-control study was conducted with 142 pregnant women participating in it. In the case group there were involved 92 mothers whose pregnancy was completed by the birth of a newborn baby suffering from the intrauterine growth restriction. The control group was made of 50 pregnant women, whose pregnancy was completed by the birth of a healthy neonate. The research resulted in specifying the risk factors of high priority: the low standards of living (OR 3.61), chronic stress (OR-3.06), sleeping disorder (OR-3.33) and poor nutrition (OR-3.81). As regards the coexisting pathology the following was revealed: endocrine pathology (OR-3.27), ischemic heart disease (OR-4.35), arterial hypertension (OR-6.47), iron deficiency anemia (OR-4.11), pathology of respiratory system (OR-3.42), chronic genital inflammatory and infectious processes. The preeclampsia (92%) and low amniotic fluid (89%) were detected to have the high predictive value. The awareness of risk factors allows us to employ the timely measures for the reduction of negative impact on the fetus and neonate.

scholarly journals Obesity in Pregnancy – Implications on Pregnancy Events

2020 ◽  
Vol 8 (B) ◽  
pp. 1157-1161
Author(s):  
Lilia Koleva ◽  
Victoria Spasova ◽  
Marieta Popova ◽  
Valentina Petkova ◽  
Milen Dimitrov
Keyword(s):  
Pregnant Women ◽  
Preterm Births ◽  
Developed Countries ◽  
Overweight And Obesity ◽  
University Hospital ◽  
Control Group ◽  
Case Group ◽  
Normal Limits ◽  
The University ◽  
Maternal Overweight

BACKGROUND: Overweight and obesity are serious health problems in most developed countries. The percentage of young women with excessive weight who get pregnant continues to grow every year. This raises a concern about the risks of the mother and the baby during pregnancy and after birth. AIM: This study aims to determine health risk for overweight mothers and especially the risk for preterm birth. MATERIALS AND METHODS: This is a prospective and retrospective study taking place in the outpatient clinic of the University Hospital “Maichin Dom”. Our study included 105 pregnant women with BMI ≥25 kg/m2 as a case group and 91 pregnant women with BMI within normal limits as a control group. RESULTS: Mean BMI in the case group was 34.79 ± 3.71 kg/m2 and 20.20 ± 2.24 kg/m2 in the control group. Among 105 women in the case group, we registered 24.8% (n = 26) who gave birth before term. Preterm births among 91 women in the control group were registered in 17.6% (n = 16) patients. We found a significant correlation between increased BMI and the risk of increased systolic and diastolic blood pressure. Moreover, we found comorbidities in 43.8% of cases and 24.2% of controls. CONCLUSION: Maternal overweight and obesity during pregnancy are associated with increased risks of preterm delivery and complications of pregnancy. Extra efforts should be made to help women lose weight before this important period of life.

Serum microRNA expression profiling identifies serum biomarkers for HCV-related hepatocellular carcinoma

2019 ◽  
Vol 26 (4) ◽  
pp. 501-512 ◽  
Author(s):  
Jian Li ◽  
Boxun Jin ◽  
Tiezheng Wang ◽  
Wenlei Li ◽  
Zhenshun Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Expression Profiling ◽  
Serum Biomarkers ◽  
Microrna Expression ◽  
Serum Microrna

scholarly journals Serum microRNA expression profiling revealing potential diagnostic biomarkers for lung adenocarcinoma

2020 ◽  
Vol 133 (21) ◽  
pp. 2532-2542
Author(s):  
Xia Shan ◽  
Lan Zhang ◽  
Dan-Xia Zhu ◽  
Xin Zhou ◽  
Huo Zhang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Expression Profiling ◽  
Microrna Expression ◽  
Diagnostic Biomarkers ◽  
Serum Microrna

scholarly journals Genome–wide microRNA expression profiling in placentas from pregnant women exposed to BPA

2015 ◽  
Vol 8 (1) ◽  
Author(s):  
Bruna De Felice ◽  
Francesco Manfellotto ◽  
Annarita Palumbo ◽  
Jacopo Troisi ◽  
Fulvio Zullo ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Expression Profiling ◽  
Microrna Expression ◽  
Genome Wide

Serum microRNA expression profiling predict response to R-CHOP treatment in diffuse large B cell lymphoma patients

2014 ◽  
Vol 93 (10) ◽  
pp. 1735-1743 ◽  
Author(s):  
Guoqi Song ◽  
Ling Gu ◽  
Junhong Li ◽  
Zhipeng Tang ◽  
Hong Liu ◽  
...  
Keyword(s):  
B Cell ◽  
Expression Profiling ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Microrna Expression ◽  
Serum Microrna ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jun Wang ◽  
Jin-Tai Yu ◽  
Lin Tan ◽  
Yan Tian ◽  
Jing Ma ◽  
...  
Keyword(s):  
Expression Profiling ◽  
Microrna Expression ◽  
Circulating Microrna ◽  
Genome Wide

scholarly journals Risk Factors for premature birth in a hospital

2016 ◽  
Vol 24 (0) ◽  
Author(s):  
Margarita E. Ahumada-Barrios ◽  
German F. Alvarado
Keyword(s):  
Risk Factors ◽  
Prenatal Care ◽  
Pregnant Women ◽  
Premature Birth ◽  
Bivariate Analysis ◽  
Control Group ◽  
Case Group ◽  
Retrospective Case ◽  
History Of ◽  
Inadequate Prenatal Care

Abstract Objective: to determine the risk factors for premature birth. Methods: retrospective case-control study of 600 pregnant women assisted in a hospital, with 298 pregnant women in the case group (who gave birth prematurely <37 weeks) and 302 pregnant women who gave birth to a full-term newborn in the control group. Stata software version 12.2 was used. The Chi-square test was used in bivariate analysis and logistic regression was used in multivariate analysis, from which Odds Ratios (OR) and Confidence Intervals (CI) of 95% were derived. Results: risk factors associated with premature birth were current twin pregnancy (adjusted OR= 2.4; p= 0.02), inadequate prenatal care (< 6 controls) (adjusted OR= 3.2; p <0.001), absent prenatal care (adjusted OR= 3.0; p <0.001), history of premature birth (adjusted OR= 3.7; p <0.001) and preeclampsia (adjusted OR= 1.9; p= 0.005). Conclusion: history of premature birth, preeclampsia, not receiving prenatal care and receiving inadequate prenatal care were risk factors for premature birth.

scholarly journals Maternal Serum 25-Hydroxy Vitamin D Concentrations and Calcium Levels in Preeclamptic Women, Sindh, Pakistan

2021 ◽  
pp. 216-221
Author(s):  
Khalil Ahmed Memon ◽  
Hazoora Shaikh ◽  
Rukhsana Soomoro ◽  
Yasmeen Joyo ◽  
Saira Parveen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Multinomial Logistic Regression ◽  
Serum Vitamin ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

Objectives: To analyse the levels of serum 25-hydroxyvitamin D 25(OH) Dand calcium concentrations in patients with pre-eclampsia, Hyderabad, Sindh, Pakistan. Methodology: Cross sectional study was conducted at the Gynaecology and Obstetrics Department, LUHS, Hyderabad during the period of January 2020 to June 2020. Total 150 pregnant women were selected according to predesign Proforma and divided into two groups. 50 females were normal normotensive pregnant women as a control group, 100 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken for the analysis of 25-hydroxyvitamin D or 25(OH)D and calcium levels. 25(OH)D were performed on chemiluminescence, While calcium concentration of Microlab 300. Data was analysed by using SPSS version 23. Student t-test was used for analysed of continuous variables. Results: The maternal serum vitamin D and calcium levels were significantly decreased as compared to patient with preeclampsia and normotensive healthy pregnant ladies. The blood pressure also declined in case group with P<0.001.Multinomial logistic regression showed significant odd ratio of Vitamin-D and Calcium deficiency in preeclampsia. Conclusion: The present study reveals that 25-hydroxyvitamin D, and Calcium levels declined significantly in preeclamptic women, and mighty be biomarker of this life threating disease.

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