scholarly journals Abdominal Obesity-Related Disturbance of Insulin Sensitivity Is Associated with CD8+ EMRA Cells in the Elderly

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 998
Author(s):  
Tim K. Boßlau ◽  
Paulina Wasserfurth ◽  
Britta Krüger ◽  
Thomas Reichel ◽  
Jana Palmowski ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Abdominal Obesity ◽  
Linear Regression Analysis ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Mediation Analyses ◽  
Plasma Tryptophan ◽  
Older Volunteers ◽  
T Cell Subpopulations

Aging and overweight increase the risk of developing type 2 diabetes mellitus. In this cross-sectional study, we aimed to investigate the potential mediating role of T-EMRA cells and inflammatory markers in the development of a decreased insulin sensitivity. A total of 134 healthy older volunteers were recruited (age 59.2 (SD 5.6) years). T cell subpopulations were analyzed by flow cytometry. Furthermore, body composition, HOMA-IR, plasma tryptophan (Trp) metabolites, as well as cytokines and adipokines were determined. Using subgroup and covariance analyses, the influence of BMI on the parameters was evaluated. Moreover, correlation, multiple regression, and mediation analyses were performed. In the subgroup of participants with obesity, an increased proportion of CD8+EMRA cells and elevated concentrations of plasma kynurenine (KYN) were found compared to the lower-weight subgroups. Linear regression analysis revealed that an elevated HOMA-IR could be predicted by a higher proportion of CD8+EMRA cells and KYN levels. A mediation analysis showed a robust indirect effect of the Waist-to-hip ratio on HOMA-IR mediated by CD8+EMRA cells. Thus, the deleterious effects of abdominal obesity on glucose metabolism might be mediated by CD8+EMRA cells in the elderly. Longitudinal studies should validate this assumption and analyze the suitability of CD8+EMRA cells as early predictors of incipient prediabetes.

scholarly journals Cognitive performance and engagement in physical, social and intellectual activities in older adults: The FIBRA study

2015 ◽  
Vol 9 (3) ◽  
pp. 270-278 ◽  
Author(s):  
Giovana Sposito ◽  
Anita Liberalesso Neri ◽  
Mônica Sanches Yassuda
Keyword(s):  
Cognitive Decline ◽  
Cognitive Performance ◽  
Family Income ◽  
Linear Regression Analysis ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Multivariate Linear Regression Analysis ◽  
Cross Sectional ◽  
Cognitive Domains ◽  
Intellectual Activities

Cognitive decline in aging can negatively impact quality of life in the elderly. However, studies have shown that elderly engaged in advanced activities of daily living (AADLs) can maintain or enhance global cognitive function or specific domains. Objective: To investigate the relationship between engagement in AADLs and domains of cognition in elderly from seven different locations in Brazil. Methods: A cross-sectional study involving 2,549 elderly without cognitive deficits suggestive of dementia was conducted. Data were collected on sociodemographic characteristics, health status, the Mini-Mental State Exam (MMSE) by subdomain (orientation, memory, attention/calculus, language and constructional praxis), and engagement in AADL grouped under physical, social and intellectual activities. Results: Multivariate linear regression analysis revealed an association, albeit modest, between intellectual AADLs and the domains orientation, attention/calculus, language and constructional praxis (R2=0.005, 0.008, 0.021, and 0.021 respectively). Social AADLs were correlated with memory (R2=0.002) and language (R2=0.004) domains. No association was found between physical AADLs and MMSE domains. Schooling and family income were the sociodemographic variables exhibiting the strongest relationship with cognitive domains. Conclusion: The study found associations between intellectual and social AADLs with higher cognitive performance, suggesting that active aging can provide opportunities to attenuate cognitive decline in aging.

scholarly journals Association of sedentary behavior with overweight and abdominal obesity in older adults

2019 ◽  
Vol 24 ◽  
pp. 1-7
Author(s):  
Talita Inácio Martins Resende ◽  
Joilson Meneguci ◽  
Jeffer Eidi Sasaki ◽  
Álvaro da Silva Santos ◽  
Renata Damião
Keyword(s):  
Older Adults ◽  
Waist Circumference ◽  
Sedentary Behavior ◽  
Body Mass ◽  
Abdominal Obesity ◽  
The Elderly ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Behavioral Variables

The aim of this study was to examine the association of sedentary behavior with overweight and abdominal obesity in older adults. This was a cross-sectional study with older men and women residing in the municipalities of the Regional Health Superintendency of Uberaba, Minas Gerais. Sedentary behavior was assessed according to the time spent sitting on a weekday and a weekend day. Body mass, height and waist circumference were measured. Excess weight was determined by means of body mass index, while abdominal obesity by waist circumference. Poisson regression analyzes with robust variance were used to examine the association of sedentary behavior with overweight and abdominal obesity. The total sample consisted of 3223 older people (61.3% women), with a mean age of 70 ± 7.26 years. There was no association between quartiles of sedentary behavior and overweight (2nd quartile: PR = 0.99; 95%CI: 0.94–1.05; 3rd quartile: PR = 0.99; 95%CI: 0.93–1.07; 4th quartile: PR = 1.07; 95%CI: 1.00–1.13) and abdominal obesity (2nd quartile: PR = 1.04; 95%CI: 1.00–1.08; 3rd quartile: PR = 1.03; 95%CI: 0.98–1.08; 4th quartile: PR = 0.98; 95%CI: 0.94–1.03) when analyses were adjusted for sociodemographic, health perception and behavioral variables. The sedentary behavior was not associated with overweight and abdominal obesity in the elderly.

scholarly journals Socio-Demographic Determinants of Quality of Life among Older People, a Population-Based Study

2018 ◽  
Author(s):  
Victoria Momenabadi ◽  
Mohammad Hossein Kaveh ◽  
Mahin Nazari ◽  
Leila Ghahremani
Keyword(s):  
Quality Of Life ◽  
Social Participation ◽  
Linear Regression Analysis ◽  
Life Quality ◽  
The Elderly ◽  
Population Based ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional

Introduction: Social participation is considered one dimension and also determinant of quality of life. The level of social participation of the elderly is influenced by various components such as socio-economic and demographic factors. The present study aimed to assess the relationship between social participation, quality of life, and some socio- economic factors in community dwelling elderly in Kerman, Iran. Methods: This cross-sectional study was conducted on 250 communities dwelling old people in Kerman in 2017 selected through random sampling. The data were collected using researcher-made Social Participation questionnaire and WHOQOL-BREF questionnaires. The data were analyzed using Pearson’s correlation coefficient, t-test, one-way ANOVA, and linear regression analysis. Results: The results revealed the participants’ mean score of social participation was above fifty. Social participation was significantly associated with age (p < 0.001), marital status (p = 0.004), education level (p < 0.001), and occupation (p = 0.021). A significant direct correlation was also observed between social participation and quality of life (p < 0.001), and social participation determined 21 % of variance of life quality score (p < 0.001). Conclusion: With the increase in social participation of the elderly, their quality of life improves. Establishing nongovernmental organizations, charities, and associations for retirement and aging can increase the level of social participation of the elderly.

A Cross-Sectional Study of Common Health Problems of the Elderly

2011 ◽  
Vol 4 (5) ◽  
pp. 509-511
Author(s):  
Pranay Gandhi ◽  
◽  
Sunita Sharma ◽  
Prateek Gandhi
Keyword(s):  
The Elderly ◽  
Cross Sectional Study ◽  
Health Problems ◽  
Sectional Study ◽  
Cross Sectional

PHYSICAL, SOCIAL ACTIVITIES AND QUALITY OF LIFE OF THE ELDERLY LIVING IN TRUONG AN WARD, HUE CITY IN 2016

2019 ◽  
pp. 55-62
Author(s):  
Vuong Diem Khanh Doan ◽  
Ngoc Minh Chau Ho ◽  
Thi Van Ngo ◽  
Thi Bao Nga Phan ◽  
Thi Hong Phan Nguyen
Keyword(s):  
Quality Of Life ◽  
The Elderly ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Physical Activities ◽  
Social Activities ◽  
Sectional Study ◽  
Cross Sectional ◽  
Elderly Living

Background: Vietnam is entering the stage of aging population; as a result, the quality of life (QOL) of the elderly is really a matter of concern. There is a great deal of research on the quality of life of the elderly while Vietnam witnesses a lack of research on this topic, especially on how physical and social activities have impact on QOL of the elderly. Objectives: (1) To describe the situation of participation in physical, social activities and QOL of the elderly residing in Truong An Ward, Hue city. (2) To examine the association between physical, social activities and QOL among participants. Methodology: This study used cross-sectional study design. A total sample of 420 people aged 60 and above in Truong An Ward, Hue city were interviewd. The SF36 was used to measure the QOL of participants. Results: Percentage of the elderly taking part in physical activity were 66%. 49% reported having the habit of taking part in social activities. The majority of the elderly get their QOL level in three health fields, namely physical, mental and general health at above average. (56.0, 60.7 and 60.8 respectively). There were significant associations between physical activities, social activities and QOL among participants. Conclusion: The percentage of the elderly taking part in physical and social activities were still low. Besides, QOL of the elderly at the research location was not really high. It’s important to encourage the elderly taking part in physical and social activities to improve their quality of life. Key words: Physical activities, social activities, QOL, the elderly

scholarly journals Prevalence of Insomnia and Factors Associated with it Among the Elderly People of Sarangdanda VDC in Panchthar District

1970 ◽  
Vol 4 ◽  
pp. 129-142 ◽  
Author(s):  
Raj Kumar Subedi
Keyword(s):  
Elderly People ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Interview Schedule ◽  
Chi Square ◽  
Cross Sectional ◽  
Factors Associated ◽  
Keywords Alcohol ◽  
Chi Square Test ◽  
Restorative Sleep

Insomnia is one of the major and unsolved problems in older people. Most of the sleep studies report that the different forms of insomnia like Difficulty Initiating Sleep (DIS), Difficulty Maintaining Sleep (DMS) and Non-Restorative Sleep (NRS) are common among the elderly that are associated to many factors. The objective of the study was to measure the prevalence of insomnia and the factors associated to it among the elderly people. A cross-sectional study was conducted among 142 elderly people of and above 60 years of age in Sarangdanda VDC of Panchthar District of Eastern Nepal. The presence or absence of insomnia and the associated factors were assessed on them by the help of interview schedule. The results were analyzed using chi-square test in SPSS (version 11.5). DMS was the most common reported form of insomnia among the elderly followed by DIS and NRS. Association between insomnia and each of factors like use of tobacco before sleeping hours, eating too close to bedtime, use of tea/coffee before sleeping hours and use of alcohol before sleeping hours were statistically significant at 95% level of confidence. Insomnia affects a large proportion of elderly and is triggered by many factors like use of tobacco before sleeping hours, use of tea/coffee before sleeping hours, eating too close to bedtime and use of alcohol before sleeping hours. Keywords: Alcohol; tea/coffee; difficulty initiating sleep (DIS); difficulty maintaining sleep (DMS); non-restorative sleep (NRS); tobacco DOI: 10.3126/dsaj.v4i0.4517 Dhaulagiri Journal of Sociology and Anthropology Vol.4 2010 pp.129-142

scholarly journals Perceived Efficiency Outcomes, Sources and Awareness of Online Health Information among the Elderly during COVID-19

2021 ◽  
Vol 18 (15) ◽  
pp. 8121
Author(s):  
Gizell Green ◽  
Riki Tesler ◽  
Cochava Sharon
Keyword(s):  
Health Status ◽  
Health Information ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Online Health Information ◽  
Online Information ◽  
Safety Skills ◽  
Cross Sectional ◽  
Information Efficiency ◽  
Online Sources

The Internet and social media are crucial platforms for health information. Factors such as the efficiency of online health information, the outcomes of seeking online health information and the awareness of reliable sources have become increasingly important for the elderly during the COVID-19 pandemic. This study aimed to examine differences between elderly individuals’ income above and below the average monthly wage in relation to their online health information efficiency and the outcomes of seeking online health information; to evaluate types of online information sources with online health information efficiency and the outcomes of seeking online health information; and to explore online health information efficiency as a mediator between health status and awareness of online sources. A cross-sectional study design was conducted with 336 elderly participants age 65 or older. The participants volunteered to complete a questionnaire. No differences were found between the two groups regarding efficiency in retrieving health information from official online health sites and Google. Perceived efficiency mediated health status and awareness of online sources. In these challenging times, it is important to provide a tailor-made education strategy plan for reliable sources of online health information for the elderly, in order to enhance their technology safety skills. It is also important to explore other mediating variables between health status and awareness of online sources.

scholarly journals Prevalence of disabilities and non-communicable diseases in an elderly population in the Telangana state, India: a population-based cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e041755
Author(s):  
Srinivas Marmamula ◽  
Satya Brahmanandam Modepalli ◽  
Thirupathi Reddy Kumbham ◽  
Rajesh Challa ◽  
Jill E Keeffe
Keyword(s):  
Elderly Population ◽  
Self Care ◽  
The Elderly ◽  
Population Based ◽  
Cross Sectional Study ◽  
Communicable Diseases ◽  
Self Report ◽  
Sectional Study ◽  
Cross Sectional ◽  
Non Communicable Diseases

ObjectivesTo assess the prevalence of disabilities (vision, hearing, mobility, cognitive, self-care and communication) and non-communicable diseases (NCDs) among the elderly population in two districts in Telangana, India.DesignPopulation-based cross-sectional study using a cluster random sampling method to select the study clusters.SettingElderly population in Khammam and Warangal districts were recruited. Detailed interviews were conducted by trained community health workers. Personal and demographic information such as age, gender, level of education and a self-report of NCDs was collected. The Washington Disability Questionnaire was administered to assess the presence of disabilities.Participants1821 participants aged ≥60 years, 54.5% were women, and 73.3% had no education.Primary outcome measurePrevalence of disabilities and NCDs.ResultsOverall, the prevalence of at least disability was 20.3% (95% CI 16.3 to 24.9). The prevalence of self- reported disabilities were: seeing (5.9%; 95% CI 4.4 to 7.8), mobility (12.8%; 95% CI 9.7 to 16.8), hearing (3.6%; 95% CI 2.7 to 4.8), cognition (4.8%; 95% CI 3.5 to 6.7), self-care (3.3%; 95% CI 2.3 to 4.7) and communication (1.8%; 95% CI 1.2 to 2.6). Overall, the prevalence of at least one NCD was 34.2% (95% CI 30.9 to 37.7). Hypertension was the most common systemic condition (25.4%; 95% CI 22.4 to 28.7), followed by diabetes (9.0%; 95% CI 7.3 to 11.0), and body pains (muscle-skeletal) (9.9%; 95% CI 8.1 to 12.2).ConclusionEvery fifth elderly person in the districts of Khammam and Warangal in Telangana had at least one self-reported disability. Besides, a third of the elderly had at least one NCD. There is a definite need to develop comprehensive public health strategies to address disabilities and NCDs in Telangana.

scholarly journals Attitudes of pharmacy students towards patient safety: a cross-sectional study from six developing countries

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e039459
Author(s):  
Abdallah Y Naser ◽  
Zahra Khalil Alsairafi ◽  
Ahmed Awaisu ◽  
Hassan Alwafi ◽  
Oriana Awwad ◽  
...  
Keyword(s):  
Developing Countries ◽  
Saudi Arabia ◽  
Patient Safety ◽  
Quality Improvement ◽  
Core Competencies ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Pharmacy Students ◽  
Sectional Study ◽  
Cross Sectional

ObjectiveTo evaluate the attitudes of undergraduate pharmacy students towards patient safety in six developing countries.DesignA cross-sectional study.SettingParticipants were enrolled from the participating universities in six countries.ParticipantsUndergraduate pharmacy students from the participating universities in six developing countries (Jordan, Saudi Arabia, Kuwait, Qatar, India and Indonesia) were invited to participate in the study between October 2018 and September 2019.Primary outcomeAttitudes towards patient safety was measured using 14-item questionnaire that contained five subscales: being quality-improvement focused, internalising errors regardless of harm, value of contextual learning, acceptability of questioning more senior healthcare professionals’ behaviour and attitude towards open disclosure. Multiple-linear regression analysis was used to identify predictors of positive attitudes towards patient safety.ResultsA total of 2595 students participated in this study (1044 from Jordan, 514 from Saudi Arabia, 134 from Kuwait, 61 from Qatar, 416 from India and 429 from Indonesia). Overall, the pharmacy students reported a positive attitude towards patient safety with a mean score of 37.4 (SD=7.0) out of 56 (66.8%). The ‘being quality-improvement focused’ subscale had the highest score, 75.6%. The subscale with the lowest score was ‘internalising errors regardless of harm’, 49.2%. Female students had significantly better attitudes towards patient safety scores compared with male students (p=0.001). Being at a higher level of study and involvement in or witnessing harm to patients while practising were important predictors of negative attitudes towards patient safety (p<0.001).ConclusionPatient safety content should be covered comprehensively in pharmacy curricula and reinforced in each year of study. This should be more focused on students in their final year of study and who have started their training. This will ensure that the next generation of pharmacists are equipped with the requisite knowledge, core competencies and attitudes to ensure optimal patient safety when they practice.

scholarly journals The relationship between the atherogenic index of plasma and arterial stiffness in essential hypertensive patients from China: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Juan Yin ◽  
Minghui Li ◽  
Lingling Yu ◽  
Feng Hu ◽  
Yu Yu ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Arterial Stiffness ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Atherogenic Index ◽  
Chinese Patients ◽  
Multivariate Linear Regression Analysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Atherogenic Index Of Plasma

Abstract Background The atherogenic index of plasma (AIP) always remains in a potential association with arterial stiffness, however, this association has not been fully discovered and needs to be studied in depth in large hypertensive patient populations. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in Chinese patients diagnosed with arterial hypertension. Methods This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides to high-density lipoprotein cholesterol levels indicated in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV). Results Data were adjusted for potential confounding variables, and multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, the same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05). Conclusion AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2. Clinical trial registration ChiCTR1800017274.

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