scholarly journals Autophagy and Mitophagy as Essential Components of Atherosclerosis

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 443
Author(s):  
Anastasia V. Poznyak ◽  
Nikita G. Nikiforov ◽  
Wei-Kai Wu ◽  
Tatiana V. Kirichenko ◽  
Alexander N. Orekhov
Keyword(s):  
Cardiovascular Disease ◽  
Control Mechanism ◽  
Deep Understanding ◽  
Component Process ◽  
Lipid Metabolism Disorders ◽  
Essential Components ◽  
Common Causes ◽  
Prevention And Treatment ◽  
Cellular Control

Cardiovascular disease (CVD) is one of the greatest health problems affecting people worldwide. Atherosclerosis, in turn, is one of the most common causes of cardiovascular disease. Due to the high mortality rate from cardiovascular diseases, prevention and treatment at the earliest stages become especially important. This requires developing a deep understanding of the mechanisms underlying the development of atherosclerosis. It is well-known that atherogenesis is a complex multi-component process that includes lipid metabolism disorders, inflammation, oxidative stress, autophagy disorders and mitochondrial dysfunction. Autophagy is a cellular control mechanism that is critical to maintaining health and survival. One of the specific forms of autophagy is mitophagy, which aims to control and remove defective mitochondria from the cell. Particularly defective mitophagy has been shown to be associated with atherogenesis. In this review, we consider the role of autophagy, focusing on a special type of it—mitophagy—in the context of its role in the development of atherosclerosis.

scholarly journals Inflammation as a determinant of healing response after coronary stent implantation

2021 ◽  
Author(s):  
Dorota Ochijewicz ◽  
Mariusz Tomaniak ◽  
Grzegorz Opolski ◽  
Janusz Kochman
Keyword(s):  
Cardiovascular Disease ◽  
High Risk ◽  
Inflammatory Response ◽  
Percutaneous Coronary Interventions ◽  
Coronary Stent Implantation ◽  
Percutaneous Coronary ◽  
Prevention And Treatment ◽  
Risk Patients ◽  
Excessive Inflammatory Response

AbstractCardiovascular disease remains the leading cause of death and morbidity worldwide. Inflammation plays an important role in the development of atherosclerosis and is associated with adverse clinical outcomes in patients after percutaneous coronary interventions. Data on stent elements that lead to excessive inflammatory response, proper identification of high–risk patients, prevention and treatment targeting residual inflammatory risk are limited. This review aims to present the role of inflammation in the context of evolving stent technologies and appraise the potential imaging modalities in detection of inflammatory response and anti-inflammatory therapies.

The role of carotenoids in the prevention and treatment of cardiovascular disease – Current state of knowledge

2017 ◽  
Vol 38 ◽  
pp. 45-65 ◽  
Author(s):  
Bartosz Kulczyński ◽  
Anna Gramza-Michałowska ◽  
Joanna Kobus-Cisowska ◽  
Dominik Kmiecik
Keyword(s):  
Cardiovascular Disease ◽  
Current State ◽  
Prevention And Treatment

The Evolving Role of Angiotensin Receptor Blockers in Heart Failure

2002 ◽  
Vol 37 (5) ◽  
pp. 474-482
Author(s):  
Patricia A. Howard
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Angiotensin Receptor Blockers ◽  
Angiotensin Receptor ◽  
Cardiovascular Pharmacotherapy ◽  
The Us ◽  
Prevention And Treatment ◽  
Recent Developments ◽  
Receptor Blockers

This continuing feature will update readers on recent developments in cardiovascular pharmacotherapy. Cardiovascular disease remains the number one killer in the US, and more clinical outcome trials have been conducted in cardiology than in any other field of medicine. Given this rapidly expanding knowledge base, pharmacists can have a significant impact on the prevention and treatment of cardiovascular disease—if they keep current with developments in drug therapy.

scholarly journals The Role of RIPK1 and RIPK3 in Cardiovascular Disease

2020 ◽  
Vol 21 (21) ◽  
pp. 8174
Author(s):  
Elise DeRoo ◽  
Ting Zhou ◽  
Bo Liu
Keyword(s):  
Cardiovascular Disease ◽  
Protein Kinase ◽  
Current Evidence ◽  
Venous Disease ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Interacting Protein ◽  
Prevention And Treatment ◽  
Peripheral Arterial

Cardiovascular diseases, including peripheral arterial and venous disease, myocardial infarction, and stroke, are the number one cause of death worldwide annually. In the last 20 years, the role of necroptosis, a newly identified form of regulated necrotic cell death, in cardiovascular disease has come to light. Specifically, the damaging role of two kinase proteins pivotal in the necroptosis pathway, Receptor Interacting Protein Kinase 1 (RIPK1) and Receptor Interacting Protein Kinase 3 (RIPK3), in cardiovascular disease has become a subject of great interest and importance. In this review, we provide an overview of the current evidence supporting a pathologic role of RIPK1 and RIPK3 in cardiovascular disease. Moreover, we highlight the evidence behind the efficacy of targeted RIPK1 and RIPK3 inhibitors in the prevention and treatment of cardiovascular disease.

Role of Panchakarma intervention in Amlapitta (Gastritis): A Critical Review

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Kaushal Kumar Sinha ◽  
Sahu Lalravi ◽  
S. Shruthi ◽  
B. A. Lohith ◽  
Imli Kumba
Keyword(s):  
Medical Science ◽  
Signs And Symptoms ◽  
The Body ◽  
Common Disease ◽  
Essential Components ◽  
Common Causes ◽  
Purification Methods ◽  
Inflammatory Drugs ◽  
H Pylori

Amlapiita is a very common disease of present era and a disease of Annavaha Strotas, and is commonly observed in these days of modernization and industrialization. 30% of the general population is suffering from gastro-oesophageal reflux and gastritis resulting in heartburn. It is very troublesome disease and can give rise to many serious problems if not treated in time. Signs and symptoms of Amlapiita are very similar to gastritis or hyperacidity. According to conventional medical science the most common causes of gastritis are H. pylori infections and prolonged use of Non-Steroidal Anti Inflammatory Drugs (NSAIDS). Gastritis is believed to affect about half of people worldwide. In 2015 there were approximately 90 million new cases of this condition. As people get older the disease becomes more common. It, along with a similar condition in the first part of the intestines known as duodenitis, resulted in 50,000 deaths in 2017. The five procedure of Panchakarma done through several procedures purify the body system by removing morbid Doshas from the body. These purification methods are essential components of the curative management of these diseases that are not controlled by palliative management.

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