scholarly journals Diagnostic Value of 11C-Methionine (MET) and 18F-Fluorothymidine (FLT) Positron Emission Tomography in Recurrent High-Grade Gliomas; Differentiation from Treatment-Induced Tissue Necrosis

Cancers ◽  
2012 ◽  
Vol 4 (1) ◽  
pp. 244-256 ◽  
Author(s):  
Hajime Shishido ◽  
Nobuyuki Kawai ◽  
Keisuke Miyake ◽  
Yuka Yamamoto ◽  
Yoshihiro Nishiyama ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Diagnostic Value ◽  
Emission Tomography ◽  
High Grade ◽  
Tissue Necrosis ◽  
Positron Emission ◽  
High Grade Gliomas

scholarly journals Dose-painted volumetric modulated arc therapy of high-grade glioma using 3,4-dihydroxy-6-[18F]fluoro-L-phenylalanine positron emission tomography

2019 ◽  
Vol 92 (1099) ◽  
pp. 20180901 ◽  
Author(s):  
Robert Kosztyla ◽  
Srinivas Raman ◽  
Vitali Moiseenko ◽  
Stefan A Reinsberg ◽  
Brian Toyota ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Volumetric Modulated Arc Therapy ◽  
Target Volume ◽  
Emission Tomography ◽  
High Grade ◽  
Dose Painting ◽  
Positron Emission ◽  
Pet Ct ◽  
Arc Therapy ◽  
High Grade Gliomas

Objective: To determine whether dose painting with volumetric modulated arc therapy for high-grade gliomas using 3,4-dihydroxy-6-[18F]fluoro-l-phenylalanine (18F-FDOPA) positron emission tomography (PET) could achieve dose-escalated coverage of biological target volumes (BTVs) without increasing the dose to cranial organs at risk (OARs). Methods: 10 patients with high-grade gliomas underwent CT, MRI, and 18F-FDOPA PET/CT images for post-operative radiation therapy planning. Two volumetric modulated arc therapy plans were retrospectively generated for each patient: a conventional plan with 60 Gy in 30 fractions to the planning target volume delineated on MRI and a dose-escalated plan with a maximum dose of 80 Gy in 30 fractions to BTVs. BTVs were created by thresholding 18F-FDOPA PET/CT uptake using a linear quadratic model that assumed tracer uptake was linearly related to tumour cell density. The maximum doses and equivalent uniform doses of OARs were compared. Results: The median volume of the planning target volume receiving at least 95% of the prescribed dose (V 95%) was 99.6% with and 99.5% without dose painting. The median V 95% was >99.2% for BTVs. The maximum doses and equivalent uniform doses to the OARs did not differ significantly between the conventional and dose-painted plans. Conclusion: Using commercially available treatment planning software, dose painting for high-grade gliomas was feasible with good BTV coverage and no significant change in the dose to OARs. Advances in knowledge: A novel treatment planning strategy was used to achieve dose painting for gliomas with BTVs obtained from 18F-FDOPA PET/CT using a radiobiological model.

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