scholarly journals Raman Spectroscopy of Head and Neck Cancer: Separation of Malignant and Healthy Tissue Using Signatures Outside the “Fingerprint” Region

Biosensors ◽  
2017 ◽  
Vol 7 (4) ◽  
pp. 20 ◽  
Author(s):  
Stephen Holler ◽  
Elaina Mansley ◽  
Christopher Mazzeo ◽  
Michael Donovan ◽  
Maximiliano Sobrero ◽  
...  
2019 ◽  
Vol 10 (18) ◽  
pp. 4876-4882 ◽  
Author(s):  
Sajanlal R. Panikkanvalappil ◽  
Chakravarthy Garlapati ◽  
Nasrin Hooshmand ◽  
Ritu Aneja ◽  
Mostafa A. El-Sayed

Real-time monitoring of the dynamics of pharmacologically generated HO-1 in mammalian cells by using plasmonically enhanced Raman spectroscopy (PERS).


2018 ◽  
Vol 23 (8) ◽  
pp. 3351-3358 ◽  
Author(s):  
Rafael Resende de Miranda ◽  
Anielle Christine Almeida Silva ◽  
Noelio Oliveira Dantas ◽  
Carlos José Soares ◽  
Veridiana Resende Novais

2010 ◽  
Vol 2 (1) ◽  
Author(s):  
Andrew T Harris ◽  
Andrew Rennie ◽  
Haroon Waqar-Uddin ◽  
Sarah R Wheatley ◽  
Samit K Ghosh ◽  
...  

Author(s):  
Daniel Troeltzsch ◽  
Seyd Shnayien ◽  
Robert Gaudin ◽  
Keno Bressem ◽  
Kilian Kreutzer ◽  
...  

BACKGROUND: Post-therapeutic tissue is bradytrophic and thus has low perfusion values in PCT. In contrast, malignant tissue is expected to show higher perfusion values as cancer growth partially depends on angiogenesis. OBJECTIVES: This prospective study investigates perfusion computed tomography (PCT) for the post-therapeutic detection of cancer in the head and neck region. METHODS: 85 patients underwent PCT for 1) initial work-up of head and neck cancer (HNC; n=22) or 2) for follow-up (n=63). Regions of interest (ROIs) were placed in confirmed tumour, a corresponding location of benign tissue, and reference tissue. Perfusion was calculated using a single input maximum slope algorithm. Statistical analysis was performed with the Mann-Whitney U-test. RESULTS: PCT allowed significant differentiation of malignant tissue from post-therapeutic tissue after treatment for HNC (p=0.018). Significance was even greater after normalization of perfusion values (p=0.007). PCT allowed highly significant differentiation of HNC from reference tissue (p<0.001). CONCLUSIONS: PCT provides significantly distinct perfusion values for malignant and benign as well as post-therapeutically altered tissue in the head and neck area, thus allowing differentiation of cancer from healthy tissue. Our results show that PCT in conjunction with a standard algorithm is a potentially powerful HNC diagnostic tool.


1998 ◽  
Vol 23 (4) ◽  
pp. 376-376
Author(s):  
Quak ◽  
Van Bokhorst ◽  
Klop ◽  
Van Leeuwen ◽  
Snow

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