scholarly journals 3D-PAD: Paper-Based Analytical Devices with Integrated Three-Dimensional Features

Biosensors ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 84
Author(s):  
James S. Ng ◽  
Michinao Hashimoto
Keyword(s):  
Melting Point ◽  
Organic Solvents ◽  
Fused Deposition Modeling ◽  
Colorimetric Assay ◽  
Three Dimensional ◽  
Biological Assays ◽  
Fused Deposition ◽  
Interfacial Energies ◽  
Liquid Samples ◽  
Deposition Modeling

This paper describes the use of fused deposition modeling (FDM) printing to fabricate paper-based analytical devices (PAD) with three-dimensional (3D) features, which is termed as 3D-PAD. Material depositions followed by heat reflow is a standard approach for the fabrication of PAD. Such devices are primarily two-dimensional (2D) and can hold only a limited amount of liquid samples in the device. This constraint can pose problems when the sample consists of organic solvents that have low interfacial energies with the hydrophobic barriers. To overcome this limitation, we developed a method to fabricate PAD integrated with 3D features (vertical walls as an example) by FDM 3D printing. 3D-PADs were fabricated using two types of thermoplastics. One thermoplastic had a low melting point that formed hydrophobic barriers upon penetration, and another thermoplastic had a high melting point that maintained 3D features on the filter paper without reflowing. We used polycaprolactone (PCL) for the former, and polylactic acid (PLA) for the latter. Both PCL and PLA were printed with FDM without gaps at the interface, and the resulting paper-based devices possessed hydrophobic barriers consisting of PCL seamlessly integrated with vertical features consisting of PLA. We validated the capability of 3D-PAD to hold 30 μL of solvents (ethanol, isopropyl alcohol, and acetone), all of which would not be retained on conventional PADs fabricated with solid wax printers. To highlight the importance of containing an increased amount of liquid samples, a colorimetric assay for the formation of dimethylglyoxime (DMG)-Ni (II) was demonstrated using two volumes (10 μL and 30 μL) of solvent-based dimethylglyoxime (DMG). FDM printing of 3D-PAD enabled the facile construction of 3D structures integrated with PAD, which would find applications in paper-based chemical and biological assays requiring organic solvents.

Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering

2021 ◽  
pp. 002199832098856
Author(s):  
Marcela Piassi Bernardo ◽  
Bruna Cristina Rodrigues da Silva ◽  
Luiz Henrique Capparelli Mattoso
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Poly Lactic Acid ◽  
Scanning Calorimetry ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

Injured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft.

Synthesis and properties of modified PBT for FDM

2017 ◽  
Vol 23 (4) ◽  
pp. 804-810 ◽  
Author(s):  
Shiqing Cao ◽  
Dandan Yu ◽  
Weilan Xue ◽  
Zuoxiang Zeng ◽  
Wanyu Zhu
Keyword(s):  
Mechanical Properties ◽  
Impact Strength ◽  
Fused Deposition Modeling ◽  
Complex Structure ◽  
Three Dimensional ◽  
Sebacic Acid ◽  
Wire Drawing ◽  
Content Type ◽  
Fused Deposition ◽  
Deposition Modeling

Purpose The purpose of this paper is to prepare a new modified polybutylene terephalate (MPBT) for fused deposition modeling (FDM) to increase the variety of materials compatible with printing. And the printing materials can be used to print components with a complex structure and functional mechanical parts. Design/methodology/approach The MPBT, poly(butylene terephalate-co-isophthalate-co-sebacate) (PBTIS), was prepared for FDM by direct esterification and subsequent polycondensation using terephthalic acid (PTA), isophthalic acid (PIA), sebacic acid (SA) and 1,4-butanediol (BDO). The effects of the content of PIA (20-40 mol%) on the mechanical properties of PBTIS were investigated when the mole per cent of SA (αSA) is zero. The effects of αSA (0-7mol%) on the thermal, rheological and mechanical properties of PBTIS were investigated at nPTA/nPIA = 7/3. A desktop wire drawing and extruding machine was used to fabricate the filaments, whose printability and anisotropy were tested by three-dimensional (3D) printing experiments. Findings A candidate content of PIA introducing into PBT was obtained to be about 30 per cent, and the Izod notched impact strength of PBTIS increased with the increase of αSA. The results showed that the PBTIS (nPTA/nPIA = 7/3, αSA = 3-5mol%) is suitable for FDM. Originality/value New printing materials with good Izod notched impact strength were obtained by introducing PIA and SA (nPTA/nPIA = 7/3, αSA = 3-5 mol%) into PBT and their anisotropy are better than that of ABS.

scholarly journals Fabrication of a Malaria-Ab ELISA Bioassay Platform with Utilization of Syringe-Based and 3D Printed Assay Automation

Micromachines ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 502 ◽  
Author(s):  
Christopher Lim ◽  
Yangchung Lee ◽  
Lawrence Kulinsky
Keyword(s):  
Fused Deposition Modeling ◽  
Color Change ◽  
Colorimetric Assay ◽  
Smart Phone ◽  
Automated System ◽  
Fused Deposition ◽  
Colorimetric Test ◽  
Qualitative Detection ◽  
Deposition Modeling ◽  
Automated Platform

We report on the fabrication of a syringe-based platform for automation of a colorimetric malaria-Ab assay. We assembled this platform from inexpensive disposable plastic syringes, plastic tubing, easily-obtainable servomotors, and an Arduino microcontroller chip, which allowed for system automation. The automated system can also be fabricated using stereolithography (SLA) to print elastomeric reservoirs (used instead of syringes), while platform framework, including rack and gears, can be printed with fused deposition modeling (FDM). We report on the optimization of FDM and SLA print parameters, as well as post-production processes. A malaria-Ab colorimetric test was successfully run on the automated platform, with most of the assay reagents dispensed from syringes. Wash solution was dispensed from an SLA-printed elastomeric reservoir to demonstrate the feasibility of both syringe and elastomeric reservoir-based approaches. We tested the platform using a commercially available malaria-Ab colorimetric assay originally designed for spectroscopic plate readers. Unaided visual inspection of the assay solution color change was sufficient for qualitative detection of positive and negative samples. A smart phone application can also be used for quantitative measurement of the assay color change.

scholarly journals Accuracy of three-dimensional dental resin models created by fused deposition modeling, stereolithography, and Polyjet prototype technologies: A comparative study

2018 ◽  
Vol 88 (3) ◽  
pp. 363-369 ◽  
Author(s):  
Raymund E. Rebong ◽  
Kelton T. Stewart ◽  
Achint Utreja ◽  
Ahmed A. Ghoneima
Keyword(s):  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Vertical Plane ◽  
Physical Models ◽  
Dental Resin ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
School Of Dentistry ◽  
Plaster Models ◽  
Plaster Casts

ABSTRACT Objectives: The aim of this study was to assess the dimensional accuracy of fused deposition modeling (FDM)–, Polyjet-, and stereolithography (SLA)–produced models by comparing them to traditional plaster casts. Materials and A total of 12 maxillary and mandibular posttreatment orthodontic plaster casts were selected from the archives of the Orthodontic Department at the Indiana University School of Dentistry. Plaster models were scanned, saved as stereolithography files, and printed as physical models using three different three-dimensional (3D) printers: Makerbot Replicator (FDM), 3D Systems SLA 6000 (SLA), and Objet Eden500V (Polyjet). A digital caliper was used to obtain measurements on the original plaster models as well as on the printed resin models.Methods: Results: Comparison between the 3D printed models and the plaster casts showed no statistically significant differences in most of the parameters. However, FDM was significantly higher on average than were plaster casts in maxillary left mixed plane (MxL-MP) and mandibular intermolar width (Md-IMW). Polyjet was significantly higher on average than were plaster casts in maxillary intercanine width (Mx-ICW), mandibular intercanine width (Md-ICW), and mandibular left mixed plane (MdL-MP). Polyjet was significantly lower on average than were plaster casts in maxillary right vertical plane (MxR-vertical), maxillary left vertical plane (MxL-vertical), mandibular right anteroposterior plane (MdR-AP), mandibular right vertical plane (MdR-vertical), and mandibular left vertical plane (MdL-vertical). SLA was significantly higher on average than were plaster casts in MxL-MP, Md-ICW, and overbite. SLA was significantly lower on average than were plaster casts in MdR-vertical and MdL-vertical. Conclusions: Dental models reconstructed by FDM technology had the fewest dimensional measurement differences compared to plaster models.

scholarly journals 3D-Printed Soft Structure of Polyurethane and Magnetorheological Fluid: A Proof-of-Concept Investigation of its Stiffness Tunability

Micromachines ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 655 ◽  
Author(s):  
Seong-Woo Hong ◽  
Ji-Young Yoon ◽  
Seong-Hwan Kim ◽  
Sun-Kon Lee ◽  
Yong-Rae Kim ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
Permanent Magnets ◽  
Thermoplastic Polyurethane ◽  
Three Dimensional ◽  
Magnetorheological Fluid ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed ◽  
Dimensional Printing

In this study, a soft structure with its stiffness tunable by an external field is proposed. The proposed soft beam structure consists of a skin structure with channels filled with a magnetorheological fluid (MRF). Two specimens of the soft structure are fabricated by three-dimensional printing and fused deposition modeling. In the fabrication, a nozzle is used to obtain channels in the skin of the thermoplastic polyurethane, while another nozzle is used to fill MRF in the channels. The specimens are tested by using a universal tensile machine to evaluate the relationships between the load and deflection under two different conditions, without and with permanent magnets. It is empirically shown that the stiffness of the proposed soft structure can be altered by activating the magnetic field.

Denture flask fabrication using fused deposition modeling three-dimensional printing

2020 ◽  
Vol 64 (2) ◽  
pp. 231-234 ◽  
Author(s):  
Heechul Kim ◽  
Doyun Lee ◽  
Soo Young Lee ◽  
Hongso Yang ◽  
Sang-Won Park ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Dimensional Printing

scholarly journals Additive Analytics: Easy Transformation of Low-Cost Fused Deposition Modeling Three-Dimensional Printers for HPTLC Sample Application

ACS Omega ◽  
2020 ◽  
Vol 5 (19) ◽  
pp. 11147-11150 ◽  
Author(s):  
Dirk Volker Woortman ◽  
Martina Haack ◽  
Norbert Mehlmer ◽  
Thomas B. Brück
Keyword(s):  
Fused Deposition Modeling ◽  
Low Cost ◽  
Three Dimensional ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Sample Application

scholarly journals Rice straw powder/polylactic acid biocomposites for three-dimensional printing

2020 ◽  
Vol 29 ◽  
pp. 2633366X2096736
Author(s):  
Wangwang Yu ◽  
Lili Dong ◽  
Wen Lei ◽  
Jianan Shi
Keyword(s):  
Polylactic Acid ◽  
Rice Straw ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Soil Burial ◽  
Fused Deposition ◽  
Before And After ◽  
Deposition Modeling ◽  
Burial Duration

The research aim of this work was to understand the effects of the soil burial of rice straw on the morphology and properties of 3D-printed rice straw powder (RSP)/polylactic acid (PLA) biocomposites. The rice straw buried in the soil for various days was grounded and sieved into powder at 120 mesh. The RSP was then mixed with PLA at a mass ratio of 15/100 and the mixture was extruded into filament, followed by a fused deposition modeling 3D printing process. The as-prepared products were characterized in terms of morphological, mechanical, thermal, and nonisothermal crystallization properties. The results show that cavities with large holes induced by fused deposition modeling exhibit on the cross section of RSP/PLA biocomposite. The longer the burial duration of rice straw, the more the cavities with large holes could be observed on the surface. Therefore, soil burial of rice straw improved the thermal stability of the biocomposites while depressing their mechanical properties due to the amplification of the cavities. The crystallinity of the biocomposites was maintained at a low level (<9%) before and after the soil burial process.

scholarly journals Novel Method for the Manufacture of Complex CFRP Parts Using FDM-based Molds

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2220
Author(s):  
Paul Bere ◽  
Calin Neamtu ◽  
Razvan Udroiu
Keyword(s):  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Acrylonitrile Butadiene Styrene ◽  
The Novel ◽  
Reinforced Polymers ◽  
Fused Deposition ◽  
Molded Parts ◽  
Deposition Modeling ◽  
Composite Tooling ◽  
Novel Method

Fibre-reinforced polymers (FRP) have attracted much interest within many industrial fields where the use of 3D printed molds can provide significant cost and time savings in the production of composite tooling. Within this paper, a novel method for the manufacture of complex-shaped FRP parts has been proposed. This paper features a new design of bike saddle, which was manufactured through the use of molds created by fused deposition modeling (FDM), of which two 3D printable materials were selected, polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS), and these molds were then chemically and thermally treated. The novel bike saddles were fabricated using carbon fiber-reinforced polymer (CFRP), by vacuum bag technology and oven curing, utilizing additive manufactured (AM) molds. Following manufacture the molded parts were subjected to a quality inspection, using non-contact three-dimensional (3D) scanning techniques, where the results were then statistically analyzed. The statistically analyzed results state that the main deviations between the CAD model and the manufactured CFRP parts were within the range of ±1 mm. Additionally, the weight of the upper part of the saddles was found to be 42 grams. The novel method is primarily intended to be used for customized products using CFRPs.

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