scholarly journals The Role of Electronic Noses in Phenotyping Patients with Chronic Obstructive Pulmonary Disease

Biosensors ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 171 ◽  
Author(s):  
Simone Scarlata ◽  
Panaiotis Finamore ◽  
Martina Meszaros ◽  
Silvano Dragonieri ◽  
Andras Bikov
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Related Factors ◽  
Obstructive Pulmonary Disease ◽  
Electronic Noses ◽  
Non Invasive ◽  
Exhaled Breath Analysis ◽  
Invasive Method

Chronic obstructive pulmonary disease (COPD) is a common progressive disorder of the respiratory system which is currently the third leading cause of death worldwide. Exhaled breath analysis is a non-invasive method to study lung diseases, and electronic noses have been extensively used in breath research. Studies with electronic noses have proved that the pattern of exhaled volatile organic compounds is different in COPD. More recent investigations have reported that electronic noses could potentially distinguish different endotypes (i.e., neutrophilic vs. eosinophilic) and are able to detect microorganisms in the airways responsible for exacerbations. This article will review the published literature on electronic noses and COPD and help in identifying methodological, physiological, and disease-related factors which could affect the results.

scholarly journals Exhaled breath condensate: a potential tool to evaluate the relationship between inflammation and dyspnea in patients with chronic obstructive pulmonary disease

2021 ◽  
Vol 5 (1) ◽  
pp. 3-7
Author(s):  
Stephanos Patsiris ◽  
Grigoris Stelios ◽  
Ilias Papanikolaou ◽  
Themis Exarchos ◽  
Panayiotis Vlamos
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Exhaled Breath Condensate ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Subjective Character ◽  
Obstructive Pulmonary Disease ◽  
Non Invasive ◽  
Markers Of Inflammation ◽  
Breath Condensate

Chronic obstructive pulmonary disease (COPD) is a respiratory disease with high prevalence. Many factors contribute to its development, and probably that leads to its various clinical pictures. Inflammation is the mechanism responsible for the structural alterations in the lungs. Despite its heterogeneity, there are a couple of primary symptoms characterizing it, which are chronic and productive cough and dyspnea. The understanding of dyspnea in COPD is based on theories deriving from the interaction of a network formed between the cardiorespiratory and the neuromuscular system and their receptors. Many factors contribute to its occurrence, making it complex and giving it a very subjective character for a person to perceive. Various methods are used to study COPD. Non-invasive ones seem to attract attention nowadays. One of them is the exhaled breath condensate. It is a biofluid with rich content, which can capture a picture of the pathological processes happening in the lungs. Its study has shown that some markers of inflammation and oxidative stress, such as 8-isoprostane and H2O2, are elevated and able to connect dyspnea and inflammation. Additionally, they seem to provide information of the ongoing inflammatory process in the lungs as well as a picture of the severity of the symptoms. This evidence may enhance the association of dyspnea with dysfunctional breathing. Despite these interesting findings, further research is necessary both in dyspnea and inflammation in COPD to clarify their mechanisms and connective pathways. The utility of non-invasive techniques such as the exhaled breath condensate could be of significant help, but its establishment in the medical field requires extra studies.

scholarly journals Chronic non-invasive ventilation for chronic obstructive pulmonary disease

2021 ◽  
Vol 2021 (8) ◽  
Author(s):  
Tim Raveling ◽  
Judith Vonk ◽  
Fransien M Struik ◽  
Roger Goldstein ◽  
Huib AM Kerstjens ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Invasive Ventilation ◽  
Obstructive Pulmonary Disease ◽  
Non Invasive ◽  
Non Invasive Ventilation
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