scholarly journals EndoBarrier™ Implantation Rapidly Improves Insulin Sensitivity in Obese Individuals with Type 2 Diabetes Mellitus

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 574
Author(s):  
Anna Obermayer ◽  
Norbert J. Tripolt ◽  
Faisal Aziz ◽  
Christoph Högenauer ◽  
Felix Aberer ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Gastric Bypass Surgery ◽  
Glycated Haemoglobin ◽  
Haemoglobin A1c ◽  
Long Term Effects ◽  
Beneficial Effects

The EndoBarrier™ medical device is a duodenal-jejunal bypass liner designed to mimic the effects of gastric bypass surgery to induce weight loss and glycaemic improvement. In this study, 10 participants with type 2 diabetes mellitus (T2DM), a mean body mass index (BMI) of 43.3 ± 5.0 (kg/m2) and a mean glycated haemoglobin A1c (HbA1c) of 60.6 ± 8.6 mmol/mol were examined at baseline (before implantation of EndoBarrier™), 4 weeks after implantation, at 36 weeks (right before explantation) and 24 weeks after the removal of the device to explore the short and long-term effects on glucose metabolism. Besides a significant reduction in body weight and fat mass, EndoBarrier™ treatment significantly improved insulin sensitivity during Botnia clamp investigations after four weeks of implantation. The beneficial effects decreased over time but remained significant 24 weeks after removal of the device.

scholarly journals Beneficial Effects of Vitamin K Status on Glycemic Regulation and Diabetes Mellitus: A Mini-Review

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2485
Author(s):  
Hsin-Jung Ho ◽  
Michio Komai ◽  
Hitoshi Shirakawa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Vitamin K ◽  
Glycemic Status ◽  
Beneficial Effects ◽  
Onset Of Diabetes ◽  
Glycemic Regulation

Type 2 diabetes mellitus is a chronic disease that is characterized by hyperglycemia, insulin resistance, and dysfunctional insulin secretion. Glycemic control remains a crucial contributor to the progression of type 2 diabetes mellitus as well as the prevention or delay in the onset of diabetes-related complications. Vitamin K is a fat-soluble vitamin that plays an important role in the regulation of the glycemic status. Supplementation of vitamin K may reduce the risk of diabetes mellitus and improve insulin sensitivity. This mini-review summarizes the recent insights into the beneficial effects of vitamin K and its possible mechanism of action on insulin sensitivity and glycemic status, thereby suppressing the progression of diabetes mellitus.

Long-term effects of pioglitazone and metformin on insulin sensitivity in patients with Type 2 diabetes mellitus

2005 ◽  
Vol 22 (8) ◽  
pp. 1101-1106 ◽  
Author(s):  
M. Roden ◽  
M. Laakso ◽  
D. Johns ◽  
M. Widel ◽  
R. Urquhart ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Long Term Effects

scholarly journals Relation of Serum Adenosine Deaminase to Some Risk Factors in Type 2 Diabetes Mellitus

2016 ◽  
Vol 1 (1) ◽  
pp. 13
Author(s):  
Shashikala Magadi Dasegowda ◽  
Ashok Kumar Jeppu ◽  
Sushith ◽  
Kavitha Ashok Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Lipid Profile ◽  
Adenosine Deaminase ◽  
Serum Uric Acid ◽  
Glycated Haemoglobin ◽  
Long Term Effects

<strong>Aim</strong>: Study was conducted to compare and correlate the levels of serum adenosine deaminase and serum uric acid with Fasting Plasmaglucose (FPG), Post Prandial Blood Sugar (PPBS) and glycated hemoglobin in type 2 diabetes mellitus. <strong>Materials and Method</strong>: Study group consisted of 60 diabetics and 50 age and sex matched healthy individuals. Blood sample was collected in fasting state and two hours after the food for estimation of serum Adenosine Deaminase (ADA), uric acid, parameters of lipid profile, fasting and postprandial glucose. <strong>Result</strong>: An increased level of serum ADA, FPG, PPBS, parameters of lipid profile and glycated haemoglobin in type 2 diabetes mellitus compared to controls. A statistically significant correlation was seen between serum ADA as well as serum uric acid with, Fasting Plasma Glucose (FPG), Post Prandial Blood Glucose (PPBS), glycated haemoglobin. Serum ADA had shown significant correlation with the Triglyceride (TG), Total Cholesterol (TC), Low Density Cholesterol (LDL cholesterol). A negative correlation was seen between serum ADA acid and High Density Lipoprotein cholesterol (HDL cholesterol). <strong>Conclusion</strong>: Adenosine deaminase and serum uric acid levels increased and positively correlated with parameters of lipid profile and glycemic control. This indicates that ADA and serum uric acid can serve as predictor of glycaemic index and help to monitor the long term effects of diabetes mellitus.

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