scholarly journals 3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications

2021 ◽  
Vol 8 (6) ◽  
pp. 79
Author(s):  
Martyna Nizioł ◽  
Justyna Paleczny ◽  
Adam Junka ◽  
Amin Shavandi ◽  
Anna Dawiec-Liśniewska ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
3D Printing ◽  
Drug Release ◽  
Antimicrobial Agent ◽  
External Solution ◽  
Controlled Drug Release ◽  
Wound Dressings ◽  
Hydrogel Scaffolds ◽  
Thermoresponsive Hydrogel ◽  
Octenidine Dihydrochloride

Thermoresponsive hydrogel-based wound dressings with an incorporated antimicrobial agent can be fabricated employing 3D printing technology. A novel printable ink containing poly(N-isopropylacrylamide) (PNIPAAm) precursors, sodium alginate (ALG), methylcellulose (MC) that is laden with a mixture of octenidine dihydrochloride and 2-phenoxyethanol (Octenisept®, OCT) possess accurate printability and shape fidelity. This study also provides the protocol of ink’s use for the 3D printing of hydrogel scaffolds. The hydrogel’s physicochemical properties and drug release profiles from the hydrogel specimens to the external solution have been determined at two temperatures (20 and 37 °C). The release test showed a sustained OCT delivery into ultrapure water and the PBS solution. The temperature-responsive hydrogel exhibited antimicrobial activity against Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa and demonstrated non-cytotoxicity towards fibroblasts. The thermoresponsive behavior along with biocompatibility, antimicrobial activity, and controlled drug release make this hydrogel a promising class of materials for wound dressing applications.

scholarly journals A Study Based on Controlled Drug Release by 3D Printed Aloe-Vera Bi-Layer Tablet

2021 ◽  
pp. 522-531
Author(s):  
Anurag Verma ◽  
Piyush Mittal ◽  
Milind S. Pande ◽  
Neelanchal Trivedi
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Integral Functional ◽  
Aloe Vera ◽  
Controlled Drug Release ◽  
Immediate Release ◽  
Aloe Barbadensis ◽  
3D Printed ◽  
Medicinal Properties ◽  
Printing Techniques

Aloe-Vera or Aloe barbadensis (botanical name) is a plant with many medicinal properties and have great importance in Ayurveda. Its leaves are succulent, erect, forming a thick rosette. The internal translucent pulp of Aloe-Vera is bound to a waxy crust or cuticle, and its vascular tissues transport minerals as well as water from the soil. Aloe Vera is being used as a major skin rejuvenating product, although it has varied medicinal properties also. In the present study, an attempt to make a method to create bi-layer tablets of Aloe-Vera, utilizing 3D printing techniques is presented. The method created doesnt affect the integral functional characteristics of the tablet. The method here contains creating an immediate release and sustained release tablet for making the Aloe-Vera to be used directly by the person for its numerous health effects. The tablet is designed so to be consumed by vegans as well since it is completely herbal.

scholarly journals 3D printing of bioinspired compartmentalized capsular structure for controlled drug release

2021 ◽  
Vol 22 (12) ◽  
pp. 1022-1033
Author(s):  
Jingwen Li ◽  
Mingxin Wu ◽  
Wenhui Chen ◽  
Haiyang Liu ◽  
Di Tan ◽  
...  
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Controlled Drug Release

scholarly journals Antibiotic Conjugated Fluorescent Carbon Dots as a Theranostic Agent for Controlled Drug Release, Bioimaging, and Enhanced Antimicrobial Activity

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Mukeshchand Thakur ◽  
Sunil Pandey ◽  
Ashmi Mewada ◽  
Vaibhav Patil ◽  
Monika Khade ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Drug Release ◽  
Carbon Dots ◽  
Gradient Centrifugation ◽  
Gum Arabic ◽  
Controlled Drug Release ◽  
Careful Analysis ◽  
Vero Cells ◽  
Yeast Cells ◽  
Microwave Assisted Synthesis

A novel report on microwave assisted synthesis of bright carbon dots (C-dots) using gum arabic (GA) and its use as molecular vehicle to ferry ciprofloxacin hydrochloride, a broad spectrum antibiotic, is reported in the present work. Density gradient centrifugation (DGC) was used to separate different types of C-dots. After careful analysis of the fractions obtained after centrifugation, ciprofloxacin was attached to synthesize ciprofloxacin conjugated with C-dots (Cipro@C-dots conjugate). Release of ciprofloxacin was found to be extremely regulated under physiological conditions. Cipro@C-dots were found to be biocompatible on Vero cells as compared to free ciprofloxacin (1.2 mM) even at very high concentrations. Bare C-dots (∼13 mg mL−1) were used for microbial imaging of the simplest eukaryotic model—Saccharomyces cerevisiae (yeast). Bright green fluorescent was obtained when live imaging was performed to view yeast cells under fluorescent microscope suggesting C-dots incorporation inside the cells. Cipro@C-dots conjugate also showed enhanced antimicrobial activity against both model gram positive and gram negative microorganisms. Thus, the Cipro@C-dots conjugate paves not only a way for bioimaging but also an efficient new nanocarrier for controlled drug release with high antimicrobial activity, thereby serving potential tool for theranostics.

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

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