scholarly journals Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

2020 ◽  
Vol 7 (3) ◽  
pp. 104 ◽  
Author(s):  
Pasquale Marrazzo ◽  
Cian O’Leary
Keyword(s):  
Tissue Engineering ◽  
Recent Literature ◽  
Natural Antioxidants ◽  
Antioxidant Compounds ◽  
Injury Site ◽  
Promising Strategy ◽  
Tissue Healing ◽  
Large Panel ◽  
Tissue Recovery

Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments can be realized with the development of biocompatible redox-modulating materials. The incorporation of antioxidant compounds within implanted biomaterials should be able to retain the antioxidant activity, while also allowing graft survival and tissue recovery. This review summarizes the recent literature reporting the combined role of natural antioxidants with biomaterials. Our review highlights how such functionalization is a promising strategy in tissue engineering to improve the engraftment and promote tissue healing or regeneration.

scholarly journals Innovative and Sustainable Technologies to Enhance the Oxidative Stability of Vegetable Oils

2022 ◽  
Vol 14 (2) ◽  
pp. 849
Author(s):  
Angela Fadda ◽  
Daniele Sanna ◽  
El Hassan Sakar ◽  
Said Gharby ◽  
Maurizio Mulas ◽  
...  
Keyword(s):  
Food Processing ◽  
Edible Oils ◽  
Natural Antioxidants ◽  
Antioxidant Compounds ◽  
Food Industries ◽  
Plant Parts ◽  
Sustainable Technologies ◽  
Vegetable Wastes ◽  
Natural Foods

To meet consumers’ demand for natural foods, edible oil producers and food processing industries are searching for alternatives to synthetic antioxidants to protect oils against oxidation. Antioxidant compounds extracted from different plant parts (e.g., flowers, leaves, roots, and seeds) or sourced from agri-food industries, including residues left after food processing, attract consumers for their health properties and natural origins. This review, starting from a literature research analysis, highlights the role of natural antioxidants in the protection of edible oils against oxidation, with an emphasis on the emerging and sustainable strategies to preserve oils against oxidative damage. Sustainability and health are the main concerns of food processing industries. In this context, the aim of this review is to highlight the emerging strategies for the enrichment of edible oils with biomolecules or extracts recovered from plant sources. The use of extracts obtained from vegetable wastes and by-products and the blending with oils extracted from various oil-bearing seeds is also pointed out as a sustainable approach. The safety concerns linked to the use of natural antioxidants for human health are also discussed. This review, using a multidisciplinary approach, provides an updated overview of the chemical, technological, sustainability, and safety aspects linked to oil protection.

scholarly journals Algal Terpenoids: A Potential Source of Antioxidants for Cancer Therapy

2021 ◽  
Author(s):  
Umme Tamanna Ferdous ◽  
Zetty Norhana Balia Yusof
Keyword(s):  
Cell Cycle ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Anticancer Agents ◽  
High Sensitivity ◽  
Natural Antioxidants ◽  
Antioxidant Compounds ◽  
Preclinical And Clinical Studies ◽  
Antioxidative Property

In cancer treatment, increase in drug resistance and decrease in new chemotherapeutic drugs have become a pressing problem. Hence, searching for novel anticancer agents with less toxicity and high sensitivity is expanding gradually. Many preclinical and clinical studies indicate that natural antioxidants can help combating carcinogenicity and reduce the adverse effects on cancer therapy, when used alone or as adjuvant in chemotherapy. Consequently, marine algae pave the way for exploring more potential antioxidant compounds which have pharmaceutical importance. Algal terpenoids comprise a large group of bioactive compounds that have excellent antioxidative property and can be used as source of antioxidant in cancer therapy. This chapter summarizes the potential role of terpenoids from algal sources in inhibiting cancer cells, blocking cell cycle, hindering angiogenesis and metastasis as well as in inducing apoptosis.

scholarly journals Emergence of Three-Dimensional Printing Technology and Its Utility in Spine Surgery

2018 ◽  
Vol 12 (2) ◽  
pp. 365-371 ◽  
Author(s):  
Akshay Gadia ◽  
Kunal Shah ◽  
Abhay Nene
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Spine Surgery ◽  
Recent Literature ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
New Research ◽  
Dimensional Printing

<p>In the last decade, spine surgery has advanced tremendously. Tissue engineering and three-dimensional (3D) printing/additive manufacturing have provided promising new research avenues in the fields of medicine and orthopedics in recent literature, and their emergent role in spine surgery is encouraging. We reviewed recent articles that highlighted the role of 3D printing in medicine, orthopedics, and spine surgery and summarized the utility of 3D printing. 3D printing has shown promising results in various aspects of spine surgery and can be a useful tool for spine surgeons. The growing research on tissue bioengineering and its application in conjunction with additive manufacturing has revealed great potential for tissue bioengineering in the treatment of spinal ailments.</p>

scholarly journals The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging

2021 ◽  
Vol 11 ◽  
Author(s):  
Liuqing Yang ◽  
Yun Chen ◽  
Yan Liu ◽  
Yu Xing ◽  
Chenyun Miao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reproductive Potential ◽  
Natural Antioxidants ◽  
Protective Role ◽  
Therapeutic Interventions ◽  
Telomere Shortening ◽  
Ovarian Aging ◽  
Promising Strategy ◽  
Apoptosis And Inflammation

The ovarian system comprises vital organs in females and is of great significance for the maintenance of reproductive potential and endocrine stability. Although complex pathogenesis undoubtedly contributes to ovarian aging, increasing attention is being paid to the extensive influence of oxidative stress. However, the role of oxidative stress in ovarian aging is yet to be fully elucidated. Exploring oxidative stress-related processes might be a promising strategy against ovarian aging. In this review, compelling evidence is shown that oxidative stress plays a role in the etiology of ovarian aging and promotes the development of other ovarian aging-related etiologies, including telomere shortening, mitochondrial dysfunction, apoptosis, and inflammation. In addition, some natural antioxidants such as quercetin, resveratrol, and curcumin have a protective role in the ovaries through multiple mechanisms. These findings raise the prospect of oxidative stress modulator-natural antioxidants as therapeutic interventions for delaying ovarian aging.

scholarly journals Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders?

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1186
Author(s):  
Luca Pangrazzi ◽  
Luigi Balasco ◽  
Yuri Bozzi
Keyword(s):  
Autism Spectrum Disorders ◽  
Natural Antioxidants ◽  
Autism Spectrum ◽  
Nutraceutical Compounds ◽  
Promising Strategy ◽  
Autistic People ◽  
Spectrum Disorders ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Autism spectrum disorders (ASD) are a group of neurodevelopmental syndromes with both genetic and environmental origins. Several recent studies have shown that inflammation and oxidative stress may play a key role in supporting the pathogenesis and the severity of ASD. Thus, the administration of anti-inflammatory and antioxidant molecules may represent a promising strategy to counteract pathological behaviors in ASD patients. In the current review, results from recent literature showing how natural antioxidants may be beneficial in the context of ASD will be discussed. Interestingly, many antioxidant molecules available in nature show anti-inflammatory activity. Thus, after introducing ASD and the role of the vitamin E/vitamin C/glutathione network in scavenging intracellular reactive oxygen species (ROS) and the impairments observed with ASD, we discuss the concept of functional food and nutraceutical compounds. Furthermore, the effects of well-known nutraceutical compounds on ASD individuals and animal models of ASD are summarized. Finally, the importance of nutraceutical compounds as support therapy useful in reducing the symptoms in autistic people is discussed.

scholarly journals The Potential of Honeybee Products for Biomaterial Applications

Biomimetics ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 6
Author(s):  
Martina Rossi ◽  
Pasquale Marrazzo
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Natural Products ◽  
Functional Properties ◽  
Recent Literature ◽  
Polymeric Scaffolds ◽  
Tissue Healing ◽  
Antioxidant Agents ◽  
Biomaterial Scaffolds ◽  
Healing Property

The development of biomaterials required continuous improvements in their properties for new tissue engineering applications. Implants based on biocompatible materials and biomaterial-based dressings are susceptible to infection threat; moreover, target tissues can suffer injuring inflammation. The inclusion of nature-derived bioactive compounds usually offers a suitable strategy to expand or increase the functional properties of biomaterial scaffolds and can even promote tissue healing. Honey is traditionally known for its healing property and is a mixture of phytochemicals that have a proven reputation as antimicrobial, anti-inflammatory, and antioxidant agents. This review discusses on the potential of honey and other honeybee products for biomaterial improvements. Our study illustrates the available and most recent literature reporting the use of these natural products combined with different polymeric scaffolds, to provide original insights in wound healing and other tissue regenerative approaches.

Role of Growth Factors and Endothelial Cells in Therapeutic Angiogenesis and Tissue Engineering

2006 ◽  
Vol 1 (3) ◽  
pp. 333-343 ◽  
Author(s):  
Masashi Nomi ◽  
Hideaki Miyake ◽  
Yoshifumi Sugita ◽  
Masato Fujisawa ◽  
Shay Soker
Keyword(s):  
Tissue Engineering ◽  
Endothelial Cells ◽  
Growth Factors ◽  
Therapeutic Angiogenesis

Effects of Myo-inositol Alone and in Combination with Seleno-Lmethionine on Cadmium-Induced Testicular Damage in Mice

2019 ◽  
Vol 12 (4) ◽  
pp. 311-323 ◽  
Author(s):  
Salvatore Benvenga ◽  
Antonio Micali ◽  
Giovanni Pallio ◽  
Roberto Vita ◽  
Consuelo Malta ◽  
...  
Keyword(s):  
Structural Changes ◽  
Natural Antioxidants ◽  
Minor Role ◽  
Positive Role ◽  
Testosterone Levels ◽  
Tnf Α ◽  
Testicular Lesions ◽  
A Minor ◽  
Immunohistochemical Analyses

Background: Cadmium (Cd) impairs gametogenesis and damages the blood-testis barrier. Objective: As the primary mechanism of Cd-induced damage is oxidative stress, the effects of two natural antioxidants, myo-inositol (MI) and seleno-L-methionine (Se), were evaluated in mice testes. Methods: Eighty-four male C57 BL/6J mice were divided into twelve groups: 0.9% NaCl (vehicle; 1 ml/kg/day i.p.); Se (0.2 mg/kg/day per os); Se (0.4 mg/kg/day per os); MI (360 mg/kg/day per os); MI plus Se (0.2 mg/kg/day); MI plus Se (0.4 mg/kg/day); CdCl2 (2 mg/kg/day i.p.) plus vehicle; CdCl2 plus MI; CdCl2 plus Se (0.2 mg/kg/day); CdCl2 plus Se (0.4 mg/kg/day); CdCl2 plus MI plus Se (0.2 mg/kg/day); and CdCl2 plus MI plus Se (0.4 mg/kg/day). After 14 days, testes were processed for biochemical, structural and immunohistochemical analyses. Results: CdCl2 increased iNOS and TNF-α expression and Malondialdehyde (MDA) levels, lowered glutathione (GSH) and testosterone, induced testicular lesions, and almost eliminated claudin-11 immunoreactivity. Se administration at 0.2 or 0.4 mg/kg significantly reduced iNOS and TNF-α expression, maintained GSH, MDA and testosterone levels, structural changes and low claudin-11 immunoreactivity. MI alone or associated with Se at 0.2 or 0.4 mg/kg significantly reduced iNOS and TNF-α expression and MDA levels, increased GSH and testosterone levels, ameliorated structural organization and increased claudin-11 patches number. Conclusion: We demonstrated a protective effect of MI, a minor role of Se and an evident positive role of the association between MI and Se on Cd-induced damages of the testis. MI alone or associated with Se might protect testes in subjects exposed to toxicants, at least to those with behavior similar to Cd.

Study of antioxidant potential in leaves, stems, nuts of Juglans regia L.

2012 ◽  
Vol 1 (10) ◽  
pp. 79 ◽  
Author(s):  
G. Raja* ◽  
Ivvala Anand Shaker ◽  
Inampudi Sailaja ◽  
R. Swaminathan ◽  
S. Saleem Basha ◽  
...  
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Juglans Regia ◽  
Radical Scavenging ◽  
Antioxidant Compounds ◽  
Free Radical Damage ◽  
Radical Damage

Natural antioxidants can protect the human body from free radicals and retard the progress of many chronic diseases as well as lipid oxidative rancidity in foods. The role of antioxidants has protected effect against free radical damage that may cause many diseases including cancer. Primary sources of naturally occurring antioxidants are known as whole grains, fruits, and vegetables. Several studies suggest that regular consumption of nuts, mostly walnuts, may have beneficial effects against oxidative stress mediated diseases such as cardiovascular disease and cancer. The role of antioxidants has attracted much interest with respect to their protective effect against free radical damage that may cause many diseases including cancer. Juglans regia L. (walnut) contains antioxidant compounds, which are thought to contribute to their biological properties. Polyphenols, flavonoids and flavonols concentrations and antioxidant activity of Leaves, Stems and Nuts extract of Juglans regia L. as evaluated using DPPH, ABTS, Nitric acid, hydroxyl and superoxide radical scavenging activity, lipid peroxidation and total oxidation activity were determined. The antioxidant activities of Leaves, Stems and Nuts extract of Juglans regia L. were concentration dependent in different experimental models and it was observed that free radicals were scavenged by the test compounds in all the models.

The Non-Causal Character of Renormalization Group Explanations

2018 ◽  
Author(s):  
Margaret Morrison
Keyword(s):  
Probability Theory ◽  
Renormalization Group ◽  
Dynamical Systems ◽  
Recent Literature ◽  
Mathematical Explanation ◽  
Causal Status ◽  
Physical Information ◽  
The Relationship ◽  
Structural Aspects

After reviewing some of the recent literature on non-causal and mathematical explanation, this chapter develops an argument as to why renormalization group (RG) methods should be seen as providing non-causal, yet physical, information about certain kinds of systems/phenomena. The argument centres on the structural character of RG explanations and the relationship between RG and probability theory. These features are crucial for the claim that the non-causal status of RG explanations involves something different from simply ignoring or “averaging over” microphysical details—the kind of explanations common to statistical mechanics. The chapter concludes with a discussion of the role of RG in treating dynamical systems and how that role exemplifies the structural aspects of RG explanations which in turn exemplifies the non-causal features.

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