scholarly journals Mesenchymal Stem Cells Derived from Healthy and Diseased Human Gingiva Support Osteogenesis on Electrospun Polycaprolactone Scaffolds

2018 ◽  
Vol 5 (1) ◽  
pp. 8 ◽  
Author(s):  
Catherine Jauregui ◽  
Suyog Yoganarasimha ◽  
Parthasarathy Madurantakam
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Gingiva

scholarly journals Successful Treatment of Plaque Psoriasis with Allogeneic Gingival Mesenchymal Stem Cells: A Case Study

2020 ◽  
Vol 2020 ◽  
pp. 1-4 ◽  
Author(s):  
Sebo Gene Wang ◽  
Nicholas C. Hsu ◽  
Sebo Michelle Wang ◽  
Fu Nan Wang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Plaque Psoriasis ◽  
Inflammatory Diseases ◽  
Treatment Options ◽  
Gingival Tissue ◽  
Complete Regression ◽  
Allogeneic Mscs ◽  
Human Gingiva

Plaque psoriasis is the most common type of psoriasis that manifests as red scaly patches with white scales affecting body areas including scalp, elbows, knees, trunk, and buttocks. Although many treatment options are available including novel biologics, no cure is available. Mesenchymal stem cells (MSCs) have been safely used to treat a variety of human diseases. Allogeneic MSCs possess unique characteristics including hypoimmunogenicity, immunomodulatory, and anti-inflammatory properties, and they are currently being explored for potential therapeutic use for many systemic inflammatory diseases. The human gingival tissue is an easily accessible and obtainable source for the isolation of MSCs. MSCs from adult human gingiva are of fetal-like phenotype, multipotent, and easy to isolate and expand in vitro. Herein, we report a case of a 19-year-old man with a 5-year history of severe plaque psoriasis refractory to multiple topical and systemic therapies who was treated with allogeneic human gingival MSCs. Complete regression was achieved after 5 infusions with no adverse reaction occurred. The patient has been followed for three years and has remained disease free.

Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine

2010 ◽  
Vol 393 (3) ◽  
pp. 377-383 ◽  
Author(s):  
Geetanjali B. Tomar ◽  
Rupesh K. Srivastava ◽  
Navita Gupta ◽  
Amruta P. Barhanpurkar ◽  
Satish T. Pote ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Human Gingiva

Human gingiva-derived mesenchymal stem cells are therapeutic in lupus nephritis through targeting of CD39−CD73 signaling pathway

2020 ◽  
Vol 113 ◽  
pp. 102491
Author(s):  
Junlong Dang ◽  
Zhenjian Xu ◽  
Anping Xu ◽  
Yan Liu ◽  
Qingling Fu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lupus Nephritis ◽  
Signaling Pathway ◽  
Human Gingiva

Neural Crest Stem-Like Cells Non-genetically Induced from Human Gingiva-Derived Mesenchymal Stem Cells Promote Facial Nerve Regeneration in Rats

2018 ◽  
Vol 55 (8) ◽  
pp. 6965-6983 ◽  
Author(s):  
Qunzhou Zhang ◽  
Phuong D. Nguyen ◽  
Shihong Shi ◽  
Justin C. Burrell ◽  
Qilin Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Facial Nerve ◽  
Neural Crest ◽  
Nerve Regeneration ◽  
Human Gingiva

Prolonged Expansion Induces Spontaneous Neural Progenitor Differentiation from Human Gingiva-Derived Mesenchymal Stem Cells

2017 ◽  
Vol 19 (6) ◽  
pp. 389-401 ◽  
Author(s):  
Thangavelu Soundara Rajan ◽  
Domenico Scionti ◽  
Francesca Diomede ◽  
Adriano Piattelli ◽  
Placido Bramanti ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neural Progenitor ◽  
Human Gingiva

scholarly journals B7-H1 Promotes the Functional Effect of Human Gingiva-Derived Mesenchymal Stem Cells on Collagen-Induced Arthritis Murine Model

2020 ◽  
Vol 28 (11) ◽  
pp. 2417-2429
Author(s):  
Wenbin Wu ◽  
Ze Xiu Xiao ◽  
Donglan Zeng ◽  
Feng Huang ◽  
Julie Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Murine Model ◽  
Functional Effect ◽  
Collagen Induced Arthritis ◽  
Human Gingiva

Effects of Hypoxia on the Immunomodulatory Properties of Human Gingiva–Derived Mesenchymal Stem Cells

2014 ◽  
Vol 94 (1) ◽  
pp. 69-77 ◽  
Author(s):  
C.M. Jiang ◽  
J. Liu ◽  
J.Y. Zhao ◽  
L. Xiao ◽  
S. An ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Gingiva ◽  
Immunomodulatory Properties

Isolation and Characterization of Mesenchymal Stem Cells from Human Gingiva

2020 ◽  
Vol 14 (1) ◽  
pp. 16-27 ◽  
Author(s):  
A. M. Koltsova ◽  
V. V. Zenin ◽  
V. I. Turilova ◽  
T. K. Yakovleva ◽  
G. G. Poljanskaya
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Isolation And Characterization ◽  
Human Gingiva

scholarly journals Human Gingiva-Derived Mesenchymal Stem Cells Elicit Polarization of M2 Macrophages and Enhance Cutaneous Wound Healing

Stem Cells ◽  
2010 ◽  
Vol 28 (10) ◽  
pp. 1856-1868 ◽  
Author(s):  
Qun-Zhou Zhang ◽  
Wen-Ru Su ◽  
Shi-Hong Shi ◽  
Petra Wilder-Smith ◽  
Andy Peng Xiang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Cutaneous Wound Healing ◽  
M2 Macrophages ◽  
Cutaneous Wound ◽  
Human Gingiva

scholarly journals Short-term application of dexamethasone on stem cells derived from human gingiva reduces the expression of RUNX2 and β-catenin

2017 ◽  
Vol 45 (3) ◽  
pp. 993-1006 ◽  
Author(s):  
Bo-Bae Kim ◽  
Minji Kim ◽  
Yun-Hee Park ◽  
Youngkyung Ko ◽  
Jun-Beom Park
Keyword(s):  
Stem Cells ◽  
Polymerase Chain Reaction ◽  
Mesenchymal Stem Cells ◽  
Western Blot ◽  
Blot Analysis ◽  
Chain Reaction ◽  
Short Term ◽  
Mrna Sequencing ◽  
Human Gingiva ◽  
Polymerase Chain

Objective Next-generation sequencing was performed to evaluate the effects of short-term application of dexamethasone on human gingiva-derived mesenchymal stem cells. Methods Human gingiva-derived stem cells were treated with a final concentration of 10−7 M dexamethasone and the same concentration of vehicle control. This was followed by mRNA sequencing and data analysis, gene ontology and pathway analysis, quantitative real-time polymerase chain reaction of mRNA, and western blot analysis of RUNX2 and β-catenin. Results In total, 26,364 mRNAs were differentially expressed. Comparison of the results of dexamethasone versus control at 2 hours revealed that 7 mRNAs were upregulated and 25 mRNAs were downregulated. The application of dexamethasone reduced the expression of RUNX2 and β-catenin in human gingiva-derived mesenchymal stem cells. Conclusion The effects of dexamethasone on stem cells were evaluated with mRNA sequencing, and validation of the expression was performed with qualitative real-time polymerase chain reaction and western blot analysis. The results of this study can provide new insights into the role of mRNA sequencing in maxillofacial areas.

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