scholarly journals Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustness

2016 ◽  
Vol 3 (1) ◽  
pp. 5 ◽  
Author(s):  
Viktor Konakovsky ◽  
Christoph Clemens ◽  
Markus Müller ◽  
Jan Bechmann ◽  
Martina Berger ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Metabolic Control ◽  
Cell Cultures ◽  
Fed Batch ◽  
Process Robustness ◽  
Acid Accumulation ◽  
Batch Cell

Controlling glycation of recombinant antibody in fed-batch cell cultures

2011 ◽  
Vol 108 (11) ◽  
pp. 2600-2610 ◽  
Author(s):  
Inn H. Yuk ◽  
Boyan Zhang ◽  
Yi Yang ◽  
George Dutina ◽  
Kimberly D. Leach ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Recombinant Antibody ◽  
Fed Batch ◽  
Batch Cell

scholarly journals Probabilistic Model by Bayesian Network for the Prediction of Antibody Glycosylation in Perfusion and Fed‐Batch Cell Cultures

2021 ◽  
Author(s):  
Liang Zhang ◽  
MingLiang Wang ◽  
Andreas Castan ◽  
Håkan Hjalmarsson ◽  
Veronique Chotteau
Keyword(s):  
Bayesian Network ◽  
Cell Cultures ◽  
Probabilistic Model ◽  
Fed Batch ◽  
Batch Cell

scholarly journals Dynamics of Fermentation Parameters and Bacterial Community in High-Moisture Alfalfa Silage with or without Lactic Acid Bacteria

2021 ◽  
Vol 9 (6) ◽  
pp. 1225
Author(s):  
Shanshan Zhao ◽  
Fengyuan Yang ◽  
Yuan Wang ◽  
Xiaomiao Fan ◽  
Changsong Feng ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Bacterial Community ◽  
Ph Value ◽  
Ammoniacal Nitrogen ◽  
High Concentration ◽  
High Moisture ◽  
Acid Accumulation ◽  
Alfalfa Silage ◽  
Fermentation Parameters

The aim of this study was to gain deeper insights into the dynamics of fermentation parameters and the bacterial community during the ensiling of high-moisture alfalfa. A commercial lactic acid bacteria (YX) inoculant was used as an additive. After 15 and 30 days of ensiling, the control silage (CK) exhibited a high pH and a high concentration of ammoniacal nitrogen (NH3-N); Enterobacter and Hafnia-Obesumbacterium were the dominant genera. At 60 d, the pH value and the concentration of NH3-N in CK silage increased compared with 15 and 30 d, propionic acid and butyric acid (BA) were detected, and Garciella had the highest abundance in the bacterial community. Compared with CK silage, inoculation of YX significantly promoted lactic acid and acetic acid accumulation and reduced pH and BA formation, did not significantly reduce the concentration of NH3-N except at 60 d, and significantly promoted the abundance of Lactobacillus and decreased the abundance of Garciella and Anaerosporobacter, but did not significantly inhibit the growth of Enterobacter and Hafnia-Obesumbacterium. In conclusion, high-moisture alfalfa naturally ensiled is prone to rot. Adding YX can delay the process of silage spoilage by inhibiting the growth of undesirable microorganisms to a certain extent.

Lactic Acid Accumulation During Work. A Suggested Standardization of Work Classification

1957 ◽  
Vol 10 (1) ◽  
pp. 51-55 ◽  
Author(s):  
J. Gordon Wells ◽  
Bruno Balke ◽  
Donald D. Van Fossan
Keyword(s):  
Lactic Acid ◽  
Acid Accumulation

The Effect Of Different Pedal Types On Maximal Oxygen Consumption And Lactic Acid Accumulation

2010 ◽  
Vol 24 ◽  
pp. 1
Author(s):  
Jean M Hiebert ◽  
Don L Hoover ◽  
Michael A Best ◽  
Ashlie B Black ◽  
Ryan K Hruska ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Lactic Acid ◽  
Maximal Oxygen Consumption ◽  
Acid Accumulation
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