scholarly journals Plasmonic Tweezers towards Biomolecular and Biomedical Applications

2019 ◽  
Vol 9 (17) ◽  
pp. 3596
Author(s):  
Xue Han ◽  
Changsen Sun
Keyword(s):  
Optical Tweezers ◽  
Biomedical Applications ◽  
Short Review ◽  
Nanoscale Particles ◽  
Level Of Significance

With the capability of confining light into subwavelength scale, plasmonic tweezers have been used to trap and manipulate nanoscale particles. It has huge potential to be utilized in biomolecular research and practical biomedical applications. In this short review, plasmonic tweezers based on nano-aperture designs are discussed. A few challenges should be overcome for these plasmonic tweezers to reach a similar level of significance as the conventional optical tweezers.

From optical tweezers to optical forced oscillation: principles and potential biomedical applications

2007 ◽  
Author(s):  
Ming-Tzo Wei ◽  
Shang-Ling Liu ◽  
Te-Yu Tseng ◽  
A. Karmenyan ◽  
Arthur Chiou
Keyword(s):  
Optical Tweezers ◽  
Biomedical Applications ◽  
Forced Oscillation

Functional polymer thin films designed for antifouling materials and biosensors

2012 ◽  
Vol 66 (5) ◽  
Author(s):  
Chao Zhao ◽  
Ling-Yan Li ◽  
Ming-Ming Guo ◽  
Jie Zheng
Keyword(s):  
Thin Films ◽  
Biomedical Applications ◽  
Rational Design ◽  
Polymer Thin Films ◽  
Short Review ◽  
Photovoltaic Devices ◽  
Real World Applications ◽  
Energy Conversion And Storage ◽  
And Storage ◽  
Selection Of

AbstractPolymer thin films offer a versatile and ubiquitous platform for a wide variety of real-world applications in biomedicine, nanotechnology, catalysis, photovoltaic devices, and energy conversion and storage. Depending on the chemical composition of the polymers and the associated microenvironment, the physicochemical properties (biocompatibility, stability, wettability, adhesion, morphology, surface free energy, and others) of polymer films can be tuned for a specific application through precisely controlled surface synthesis and the incorporation of desirable and responsive functional groups. In this short review, we first summarise the methods most commonly used for the fabrication of polymer thin films. Then we discuss how these polymer thin films can be used in a selection of biomedical applications in antifouling materials and biosensors. Some directions for the rational design of polymer thin films to achieve a specific function or application are also provided.

scholarly journals "Click" chemistry as a tool to create novel biomaterials: a short review

2017 ◽  
Vol 1 (1) ◽  
pp. 22-34
Author(s):  
Mariana Barbosa ◽  
Cristina Martins ◽  
Paula Gomes
Keyword(s):  
Click Chemistry ◽  
Biomedical Applications ◽  
Recent Literature ◽  
Click Reaction ◽  
Cycloaddition Reaction ◽  
Polymeric Materials ◽  
Short Review ◽  
Dipolar Cycloaddition ◽  
Functionalization Of Polymers ◽  
Grafting Modification

In recent years, there has been a growing demand for novel strategies for biomedical applications. Chitosan is a typical cationic amino-containing polysaccharide that has been widely used due to its unique properties. The grafting modification of chitosan has been explored as an interesting method to develop multifunctional novel chitosan hybrid materials for drug delivery, tissue engineering, and other biomedical applications. Recently, “click” chemistry has been introduced into the synthesis of polymeric materials with well-defined and complex chain architectures. The Huisgen’s 1,3-dipolar cycloaddition reaction between alkynes and azides yielding triazoles is the principal example of a “click” reaction. Bioconjugation, surface modification, and orthogonal functionalization of polymers were successfully performed through this chemoselective reaction. In recent literature interest has been shown in this cycloaddition for the modification of polysaccharides, however, only a few chitosan graft copolymers have been synthesized by this technique.

scholarly journals Dark-Field Hyperspectral Microscopy for Carbon Nanotubes Bioimaging

2021 ◽  
Vol 11 (24) ◽  
pp. 12132
Author(s):  
Ilnur Ishmukhametov ◽  
Rawil Fakhrullin
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Optical Microscopy ◽  
Biomedical Applications ◽  
Dark Field ◽  
Chemical Identification ◽  
Nanoscale Particles ◽  
Spectral Identification ◽  
Tyndall Effect ◽  
Dark Field Microscopy

Carbon nanotubes have emerged as a versatile and ubiquitous nanomaterial, finding applications in industry and biomedicine. As a result, biosafety concerns that stimulated the research focused on evaluation of carbon nanotube toxicity. In addition, biomedical applications of carbon nanotubes require their imaging and identification in biological specimens. Among other methods, dark-field microscopy has become a potent tool to visualise and identify carbon nanotubes in cells, tissues, and organisms. Based on the Tyndall effect, dark-field optical microscopy at higher magnification is capable of imaging nanoscale particles in live objects. If reinforced with spectral identification, this technology can be utilised for chemical identification and mapping of carbon nanotubes. In this article we overview the recent advances in dark-field/hyperspectral microscopy for the bioimaging of carbon nanotubes.

scholarly journals Holographic acoustic tweezers

2018 ◽  
Vol 116 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Asier Marzo ◽  
Bruce W. Drinkwater
Keyword(s):  
Optical Tweezers ◽  
Biomedical Applications ◽  
Soft Matter ◽  
Input Power ◽  
Multiple Objects ◽  
Multiple Particles ◽  
Holographic Optical Tweezers ◽  
Wide Range ◽  
Acoustic Tweezers ◽  
Trapping Forces

Acoustic tweezers use sound radiation forces to manipulate matter without contact. They provide unique characteristics compared with the more established optical tweezers, such as higher trapping forces per unit input power and the ability to manipulate objects from the micrometer to the centimeter scale. They also enable the trapping of a wide range of sample materials in various media. A dramatic advancement in optical tweezers was the development of holographic optical tweezers (HOT) which enabled the independent manipulation of multiple particles leading to applications such as the assembly of 3D microstructures and the probing of soft matter. Now, 20 years after the development of HOT, we present the realization of holographic acoustic tweezers (HAT). We experimentally demonstrate a 40-kHz airborne HAT system implemented using two 256-emitter phased arrays and manipulate individually up to 25 millimetric particles simultaneously. We show that the maximum trapping forces are achieved once the emitting array satisfies Nyquist sampling and an emission phase discretization below π/8 radians. When considered on the scale of a wavelength, HAT provides similar manipulation capabilities as HOT while retaining its unique characteristics. The examples shown here suggest the future use of HAT for novel forms of displays in which the objects are made of physical levitating voxels, assembly processes in the micrometer and millimetric scale, as well as positioning and orientation of multiple objects which could lead to biomedical applications.

Design of polyglycidol-containing microspheres for biomedical applications

2012 ◽  
Vol 66 (5) ◽  
Author(s):  
Teresa Basinska ◽  
Stanislaw Slomkowski
Keyword(s):  
Biomedical Applications ◽  
Particle Diameter ◽  
Short Review ◽  
Optical Biosensors ◽  
Average Particle ◽  
Average Particle Diameter ◽  
Surface Fraction ◽  
Adsorbed Protein ◽  
Emulsion Polymerisation ◽  
Medical Diagnostic

AbstractThe paper presents a short review on the synthesis, characterisation and selected medical applications of poly(styrene/α-tert-butoxy-ω-vinylbenzyl-polyglycidol) (P(S/PGL)) microspheres. The soap-free emulsion-polymerisation of styrene and α-tert-butoxy-ω-vinylbenzyl-polyglycidol macromonomer (PGL) in water yielded core-shell microspheres with a low particle-diameter dispersity (ratio of the weight average particle diameter and the number average particle diameter). The interfacial fraction of PGL units, estimated by XPS, was in the range of 0–42 mole % depending on the concentration of the macromonomer in the polymerisation feed. The studies of adsorption of model proteins showed that the surface fraction of adsorbed protein was significantly reduced when the PGL interfacial fraction was higher than 40 mole %. The P(S/PGL) particles with covalently immobilised proteins were used for the preparation of photonic crystal assemblies suitable for applications in optical biosensors and the medical diagnostic test for the detection of Helicobacter pylori antibodies in the blood serum.

scholarly journals Biodegradable Polycaprolactone Nanoparticles Based Drug Delivery Systems: A Short Review

2018 ◽  
Vol 15 (3) ◽  
pp. 679-685 ◽  
Author(s):  
Ranjith Ramanujam ◽  
Balraj Sundaram ◽  
Ganesh Janarthanan ◽  
Elamparithi Devendran ◽  
Moorthy Venkadasalam ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Drug Carrier ◽  
Short Review ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Simple Method ◽  
Nanoprecipitation Method

Nanoparticles based drug delivery systems showing greater potential in various biomedical applications to deliver the drugs/bioactive molecules in controlled manner to the targeted site. Polycaprolactone, biodegradable polyester, owing its tailorable properties, various forms of polycaprolactone are used as drug carrier for a range of biomedical applications. Nanoprecipitation is a simple method to prepare the polycaprolactone nanoparticles to improve the bioavailability and therapeutic potential of various drugs/bioactive molecules. This short review focused on the preparation of polycaprolactone nanoparticles using nanoprecipitation method, nanoparticles-drug formulations and its use in various drug delivery applications.

scholarly journals Microfluidics Mediated Production of Foams for Biomedical Applications

Micromachines ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 83 ◽  
Author(s):  
Ilham Maimouni ◽  
Cesare M. Cejas ◽  
Janine Cossy ◽  
Patrick Tabeling ◽  
Maria Russo
Keyword(s):  
Tissue Engineering ◽  
Pore Size ◽  
Biomedical Applications ◽  
Size Control ◽  
Short Review ◽  
Solid Polymer ◽  
Liquid Foams ◽  
Solid Foams ◽  
Design Customization ◽  
Pore Size Control

Within the last decade, there has been increasing interest in liquid and solid foams for several industrial uses. In the biomedical field, liquid foams can be used as delivery systems for dermatological treatments, for example, whereas solid foams are frequently used as scaffolds for tissue engineering and drug screening. Most of the foam functionalities are largely correlated to their mechanical properties and their structure, especially bubble/pore size, shape, and interconnectivity. However, the majority of conventional foaming fabrication techniques lack pore size control which can induce important inhomogeneities in the foams and subsequently decrease their performance. In this perspective, new advanced technologies have been introduced, such as microfluidics, which offers a highly controlled production, allowing for design customization of both liquid foams and solid foams obtained through liquid-templating. This short review explores both the fabrication and the characterization of foams, with a focus on solid polymer foams, and sheds the light on how microfluidics can overcome some existing limitations, playing a crucial role in their production for biomedical applications, especially as scaffolds in tissue engineering.

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