scholarly journals Measurement of the Absolute Value of Cerebral Blood Volume and Optical Properties in Term Neonates Immediately after Birth Using Near-Infrared Time-Resolved Spectroscopy: A Preliminary Observation Study

2019 ◽  
Vol 9 (10) ◽  
pp. 2172 ◽  
Author(s):  
Aya Morimoto ◽  
Shinji Nakamura ◽  
Masashiro Sugino ◽  
Kosuke Koyano ◽  
Yinmon Htun ◽  
...  
Keyword(s):  
Optical Properties ◽  
Blood Volume ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Transition Period ◽  
Observation Study ◽  
Time Resolved ◽  
Term Neonates ◽  
Time Resolved Spectroscopy ◽  
The Absolute

The aim of this study was to use near-infrared time-resolved spectroscopy (TRS) to determine the absolute values of cerebral blood volume (CBV) and cerebral hemoglobin oxygen saturation (ScO2) during the immediate transition period in term neonates and the changes in optical properties such as the differential pathlength factor (DPF) and reduced scattering coefficient (μs’). CBV and ScO2 were measured using TRS during the first 15 min after birth by vaginal delivery in term neonates who did not need resuscitation. Within 2–3 min after birth, CBV showed various changes such as increases or decreases, followed by a gradual decrease until 15 min and then stability (mean (SD) mL/100 g brain: 2 min, 3.09 (0.74); 3 min, 3.01 (0.77); 5 min, 2.69 (0.77); 10 min, 2.40 (0.61), 15 min, 2.08 (0.47)). ScO2 showed a gradual increase, then kept increasing or became a stable reading. The DPF and μs’ values (mean (SD) at 762, 800, and 836 nm) were stable during the first 15 min after birth (DPF: 4.47 (0.38), 4.41 (0.32), and 4.06 (0.28)/cm; μs’: 6.54 (0.67), 5.82 (0.84), and 5.43 (0.95)/cm). Accordingly, we proved that TRS can stably measure cerebral hemodynamics, despite the dramatic physiological changes occurring at this time in the labor room.

scholarly journals Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tsutomu Mitsuie ◽  
Shinji Nakamura ◽  
Yinmon Htun ◽  
Yasuhiro Nakao ◽  
Makoto Arioka ◽  
...  
Keyword(s):  
Blood Volume ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Brain Injuries ◽  
Time Resolved ◽  
Time Resolved Spectroscopy ◽  
The Difference ◽  
The Relationship ◽  
Inspired Oxygen ◽  
Ischemic Encephalopathy

AbstractNeonatal hypoxic–ischemic encephalopathy is a notable cause of neonatal death and developmental disabilities. To achieve better outcomes, it is important in treatment strategy selection to categorize the degree of hypoxia ischemia and evaluate dose response. In an asphyxia piglet model with histopathological brain injuries that we previously developed, animals survived 5 days after insult and showed changes in cerebral blood volume (CBV) that reflected the severity of injuries. However, little is known about the relationship between changes in CBV during and after insult. In this study, an HI event was induced by varying the amount and timing of inspired oxygen in 20 anesthetized piglets. CBV was measured using near-infrared time-resolved spectroscopy before, during, and 6 h after insult. Change in CBV was calculated as the difference between the peak CBV value during insult and the value at the end of insult. The decrease in CBV during insult was found to correlate with the increase in CBV within 6 h after insult. Heart rate exhibited a similar tendency to CBV, but blood pressure did not. Because the decrement in CBV was larger in severe HI, the CBV increment immediately after insult is considered useful for assessing degree of HI insult.

scholarly journals Cerebral hemodynamics during neonatal transition according to mode of delivery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aya Morimoto ◽  
Shinji Nakamura ◽  
Masashiro Sugino ◽  
Kosuke Koyano ◽  
Noriko Fuke ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Transition Period ◽  
Elective Caesarean Section ◽  
Mode Of Delivery ◽  
Group Differences ◽  
Time Resolved ◽  
Term Neonates ◽  
Total Haemoglobin

AbstractCerebral haemodynamics during the immediate transition period in neonates may differ depending on whether delivery is vaginal or by caesarean section. However, these differences have never been confirmed by near-infrared time-resolved spectroscopy (TRS). Therefore, the purpose of this study was to compare cerebral blood volume (CBV) and cerebral haemoglobin oxygen saturation (ScO2) between healthy term neonates by mode of delivery. Subjects were 31 healthy term neonates who did not require resuscitation. Thirteen neonates were delivered vaginally (VD group) and 18 were delivered by elective caesarean section (CS group). Absolute oxyhaemoglobin, deoxyhaemoglobin, and total haemoglobin concentrations were measured continuously by TRS; oxyHb × 100/totalHb (ScO2) (%) and CBV (mL/100 g brain tissue) were also calculated. Measurements were started as soon as possible after birth, obtained from 1 to 2 min after birth, and continued until 15 min after birth. CBV was significantly higher in the VD group than in the CS group in the 4 min after birth but not thereafter. There were no significant between-group differences in ScO2 and SpO2. These findings indicate that there is a difference in cerebral haemodynamic patterns in the first 4 min after delivery between term neonates by mode of delivery when CBV is monitored by TRS.

scholarly journals Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy

2005 ◽  
Vol 58 (3) ◽  
pp. 568-573 ◽  
Author(s):  
Sonoko Ijichi ◽  
Takashi Kusaka ◽  
Kenichi Isobe ◽  
Kensuke Okubo ◽  
Kou Kawada ◽  
...  
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Developmental Changes ◽  
Time Resolved ◽  
Time Resolved Spectroscopy

Relationship between Changes in Cerebral Blood Volume During Hypoxic-ischemic Insult and Early Period after Insult

2021 ◽  
Author(s):  
Tsutomu Mitsuie ◽  
Shinji Nakamura ◽  
Yinmon Htun ◽  
Yasuhiro Nakao ◽  
Makoto Arioka ◽  
...  
Keyword(s):  
Blood Volume ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Brain Injuries ◽  
Treatment Strategies ◽  
Early Period ◽  
Additional Treatment ◽  
Time Resolved ◽  
Precise Prediction ◽  
The Difference

Abstract To achieve better outcomes in hypoxic-ischemic encephalopathy, categorizing the degree of the hypoxia-ischemia (HI) is important for selecting suitable candidates for therapeutic hypothermia and any additional treatment strategies. We previously developed a novel model of asphyxiated piglets with a uniform degree of histopathological brain injuries that survived for 5 days after insult and showed changes in cerebral blood volume (CBV) that reflected the severity of the brain injuries. However, little is known about the relationship between changes in CBV during and after insult. In this study, an HI event was induced by low inspired oxygen in 23 anesthetized newborn piglets, including three sham controls. CBV was measured using near-infrared time-resolved spectroscopy (TRS). Data were collected before, during, and 6 h after insult. The change in CBV was calculated as the difference between the peak CBV value during insult and the value at the end of insult. The decrease in CBV during insult was found to correlate with the increase in CBV within 6 h after insult. Heart rate exhibited a similar tendency to CBV but blood pressure did not. The CBV increment immediately after resuscitation provides a relatively precise prediction of the severity of HI insult.

Developmental changes of optical properties in infants determined by near-infrared time-resolved spectroscopy

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S228-S228 ◽  
Author(s):  
Sonoko Ijichi ◽  
Takashi Kusaka ◽  
Kenichi Isobe ◽  
Kensuke Okubo ◽  
Saneyuki Yasuda ◽  
...  
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Developmental Changes ◽  
Time Resolved ◽  
Time Resolved Spectroscopy
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