scholarly journals Preparation of Polyacrylate Hollow Microspheres via Facile Spray Drying

2019 ◽  
Vol 9 (2) ◽  
pp. 228 ◽  
Author(s):  
Pingxu Chen ◽  
Nanbiao Ye ◽  
Chaoxiong He ◽  
Lei Tang ◽  
Shuliang Li ◽  
...  
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Hollow Structure ◽  
Hollow Microspheres ◽  
Inlet Temperature ◽  
Feed Speed ◽  
Drying Method ◽  
Drying Process ◽  
Widespread Application ◽  
Hollow Structures

Polyacrylate microspheres with a hollow structure were prepared by a facile spray drying method. The effects of spray drying process parameters, including inlet temperature, atomizer rotational speed, and feed speed, on the particle size, bulk density, and morphology of the resultant polyacrylate hollow microspheres were investigated and discussed. The mechanism for the formation of the polyacrylate hollow microspheres was proposed. This facile and scalable method for preparing hollow polymer microspheres is expected to be valuable to prepare various polymer hollow structures for widespread application.

Formulation and Process Optimization of Solid Dispersion of Meloxicam and PEG8000 Prepared by Spray Drying

2009 ◽  
Vol 2 (3) ◽  
pp. 647-653
Author(s):  
Patel R.P. ◽  
Patel M. P. ◽  
Suthar A. M. ◽  
Baria A.H.
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Solid Dispersion ◽  
Feed Rate ◽  
Polymer Concentration ◽  
Drug Dissolution ◽  
In Vitro Dissolution ◽  
Inlet Temperature ◽  
Drying Method ◽  
Melting Method

The poor solubility and wettability of meloxicam leads to poor dissolution and hence shows poor bioavailability. The present study is aimed at increasing solubility of drug using solid dispersion technique. The solid binary systems were prepared using different drug: polymer ratio (1:1, 1:5 and 1:10) with polyethylene glycol 8000 by different techniques like physical mixing, melting method and spray drying method. The formulations were characterized by differential scanning colorimetry, scanning electron microscopy and in vitro dissolution rate studies. The solubility of drug increased linearly with the increase in polymer concentration. The solid dispersion of drug prepared by spray drying method demonstrated higher drug dissolution rates in comparison to solid dispersion prepared by physical mixtures, melting method and pure meloxicam. Moreover, spray drying process parameters inlet air temperature and feed rate were also optimized to obtain maximum powder yield and satisfactory particle size and compressibility. The outcome indicated that with the increase in feed rate, the powder yield and Carr’s index decreases but particle size increases. On the other hand, as the inlet temperature increases, powder yield and Carr’s index increases.

scholarly journals A DESIGN OF EXPERIMENT APPROACH FOR OPTIMIZATION AND CHARACTERIZATION OF ETODOLAC TERNARY SYSTEM USING SPRAY DRYING

2017 ◽  
Vol 9 (2) ◽  
pp. 233
Author(s):  
Amir A. Shaikh ◽  
Praveen D. Chaudhari ◽  
Sagar S. Holkar
Keyword(s):  
Particle Size ◽  
Ternary System ◽  
Spray Drying ◽  
Design Of Experiment ◽  
Particle Size Analysis ◽  
Polyvinyl Pyrrolidone ◽  
Size Analysis ◽  
Drying Method ◽  
Physical Mixtures ◽  
Pvp K30

<p><strong>Objective: </strong>The objective of the present investigation was to prepare and characterize Etodolac (ETO), Polyvinyl pyrrolidone K30 (PVP K30) and Hydroxypropyl β-cyclodextrin (HPB) ternary system in order to study the effect of complexation on solubility of ETO.</p><p><strong>Methods: </strong>Physical mixtures of a drug and polymers in different weight ratios (1:1, 1:2, 1:4) were prepared to study the effect of individual polymers on solubility of ETO. Spray drying method was used to investigate the combined effect of PVP K30 and HPB on saturation solubility (SS), Dissolution efficiency (DE) and mean dissolution time (MDT) of ETO. Design of experiment (DoE) was used for preparation and optimization of ternary system. Drug polymer interactions were analyzed with Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), Scanning electron microscopy (SEM), Xray diffraction (XRD) and particle size analysis.<strong></strong></p><p><strong>Results: </strong>Results of solubility study suggested that there was significant increase in solubility of ETO with increase in the concentration of PVP K30, Polyvinyl pyrrolidone K 90 (PVP K90) and HPB (*p&lt;0.05). This might be due to the solubilizing effect of PVP K30, PVPK90 and complex formation of ETO with HPB. Various combinations of PVP K30 and HPB prepared using DoE approach by spray drying method showed greater solubility of ETO than its physical mixtures (*p&lt;0.05). Results of FTIR, DSC, SEM, XRD and particle size analysis revealed the interaction between ETO, PVP K30 and HPB. This suggested formation of amorphous ternary system with mean particle diameter in the range of 763±1.35 nm.</p><p><strong>Conclusion: </strong>Combine use of PVP K30 and HPB with DoE approach was an effective tool for formulating ternary system of ETO.</p>

scholarly journals Effect of spray drying process parameters on Uncaria tomentosa (Willd. ex Schult.) DC. dried extracts

Revista Fitos ◽  
2020 ◽  
Vol 14 (4) ◽  
pp. 469-475
Author(s):  
Lucas Oliveira Rodrigues ◽  
Rachel Andrade de Faria ◽  
Marcos Martins Gouvêa ◽  
Carlos Augusto de Freitas Peregrino ◽  
Elizabeth Valverde Macedo ◽  
...  
Keyword(s):  
Spray Drying ◽  
Process Parameters ◽  
Inlet Temperature ◽  
Airflow Rate ◽  
Spray Nozzle ◽  
Drying Process ◽  
Process Yield ◽  
Uncaria Tomentosa ◽  
Acacia Gum ◽  
Higher Temperature

Uncaria tomentosa (Willd. ex Schult.) DC. (Cat's claw) is a plant member of the Rubiaceae family, from the Amazon region, and used in traditional medicine as raw material for phytomedicines indicated for arthritis and osteoarthritis. This study aimed to evaluate the spray drying process parameters on the properties of different extracts obtained from Uncaria tomentosa. A reduced 24-1 multifactorial design was applied to evaluate the importance of the equipment variables (pump speed, spray nozzle diameter, air inlet temperature, and atomization airflow rate) in the process. Maltodextrin and acacia gum were used as carriers in a 1:1 (m/m) ratio, considering the solid residue content of the liquid plant extract. Process yield, moisture, and hygroscopicity were evaluated as dependent variables. Higher atomization airflow rate led to higher process yield for powdered dried extracts with maltodextrin. Higher temperature led to lower moisture contents regarding powdered dried extracts with acacia gum. No variable, for any carrier, was considered significant for hygroscopicity. The best spray drying configuration for the desired characteristics (i.e. lower hygroscopicity and moisture) used the larger spray nozzle with a diameter of 1.2 mm and the higher temperature of 150 °C, with both carriers.

Effect of Several Factors on the Synthesis of Calcium Hydroxide Prepared by Spray Drying Method Using Limestone

2007 ◽  
Vol 544-545 ◽  
pp. 733-736
Author(s):  
Moon Kwan Choi ◽  
Jin Sang Cho ◽  
Sung Min Joo ◽  
Jin Koo Park ◽  
Ji Whan Ahn ◽  
...  
Keyword(s):  
Particle Size ◽  
Calcium Carbonate ◽  
Spray Drying ◽  
Feeding Rate ◽  
Spherical Shape ◽  
Initial Reaction ◽  
Outlet Temperature ◽  
Drying Method ◽  
Precipitated Calcium Carbonate ◽  
Carbonation Process

The purpose of this work is to influence of CaO concentrations of 5.0 wt.% and 10.0 wt.%, slurry feeding rate of 200~400 /min, rotating rate of drum of 5,000 and 10,000 rpm, inlet and outlet temperature on the synthesis of Ca(OH)2 powder, and the synthesis of precipitated calcium carbonate by carbonation process using Ca(OH)2 prepared by spray drying method. As the feeding rate of slurry was increased, the particle size of Ca(OH)2 was decreased. Regardless of rotating rate of drum, when the concentration of CaO was 5.0 wt.% and 10.0 wt.%, the morphology of Ca(OH)2 showed spherical shape of 10~30 μm and 20~60 μm, respectively. The specific surface area of synthesized Ca(OH)2 was 27~30 m2/g. When the initial reaction temperature was 11 °C and 30 °C, the shape and particle size of precipitated calcium carbonate synthesized in the carbonation process showed the rectangular shape of 0.1~0.4 μm and the spindle shape of 0.5~1.0 μm, respectively.

scholarly journals Application of Fuzzy Logic for Controlling Spray Drying Parameters in Production of Bignay (Antidesma Bunius) Juice Powder

2021 ◽  
Vol 25 (5) ◽  
pp. 625-631
Author(s):  
Danielle Grace D. Evangelista ◽  
Ryan Rhay P. Vicerra ◽  
Argel A. Bandala ◽  
Edwin Sybingco ◽  
Elmer P. Dadios ◽  
...  
Keyword(s):  
Fuzzy Logic ◽  
Moisture Content ◽  
Spray Drying ◽  
Fuzzy System ◽  
Cost Effective ◽  
Product Yield ◽  
Inlet Temperature ◽  
Drying Process ◽  
Production Automation ◽  
Efficiency And Productivity

Spray drying is a rapid, continuous, cost-effective, reproducible, and scalable process for reducing the moisture content of a fluid material into a solid powder. To improve this process in juice powder production, automation can be applied to increase efficiency and productivity. Hence, fuzzy logic is used in this study as a control system in the spray-drying process of concentrated liquid bignay juice into juice powder, where the inlet temperature and carrier agent concentrations affecting the properties of the juice powder, such as moisture content and product yield, are considered. The proposed fuzzy system can provide feedback to the control variables, inlet temperature, and carrier agent concentration based on the moisture content and product yield of the juice powder.

scholarly journals Effect of Drying Temperature of Small Scale Spray Dryer on Physical Properties of Coffee Powder

2020 ◽  
Vol 28 (4) ◽  
Author(s):  
Joko Nugroho Wahyu Karyadi ◽  
Dwi Ayuni ◽  
Tsania Ayu Rohani ◽  
Devi Yuni Susanti
Keyword(s):  
Moisture Content ◽  
Physical Properties ◽  
Spray Drying ◽  
Product Yield ◽  
Feed Solution ◽  
Small Scale ◽  
Inlet Temperature ◽  
Spray Dryer ◽  
Drying Process ◽  
High Product Yield

Nowadays, coffee has become one of the most favorable commodities for beverages, flavoring as well as for cosmetic industries. In Indonesia, coffee becomes more popular, especially among youngsters. In this study, the spray drying process was evaluated, giving the potential of how simple spray dryer can help local farmers of Indonesia to produce their coffee powders. One small scale of spray dryer was constructed with the total dimensions of 2.85 x 0.64 for length x width, with a height of 2.32 m. The spray dryer was equipped with a digital thermo regulator, the pneumatic nozzle system, and 4 finned heaters with the power of 2700 watt for each. The spray drying constructed was revealed to be able to produce coffee powders with fine quality. The inlet temperature of the drying chamber, as well as the initial Brix content of feed solution, were proven to affect the physical properties of powder produced such as moisture content, product yield, and solubility. The final moisture content of powders was ranged from 3 - 7% db, with the high product yield of the drying process, which could reach up to 70%.

scholarly journals Influence of combined hydrolyzed collagen and maltodextrin as carrier agents in spray drying of cocona pulp

2020 ◽  
Vol 23 ◽  
Author(s):  
Diana Patricia Vargas-Muñoz ◽  
Louise Emy Kurozawa
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Chemical Structure ◽  
Particle Diameter ◽  
Spray Dryer ◽  
Drying Process ◽  
Hydrolyzed Collagen ◽  
Bioactive Properties ◽  
Encapsulation Process ◽  
Mean Particle Diameter

Abstract This work aimed to evaluate the effect of carrier agents containing maltodextrin and protein, represented by hydrolyzed collagen on the spray drying process of cocona (Solanum sessiliflorum Dunal), and on the properties of the resulting powders. We used pre-established proportions between the solids of cocona pulp and the carrier agents (P:CA), and among carrier agents themselves, maltodextrin and hydrolyzed collagen, (MD:HC). The process was carried out in a spray dryer at an inlet air temperature of 120 ºC. We prepared twelve feed solutions containing 20% of total solids, with P:CA ratios of 1:3, 1:4, 1:5 and 1:6, and MD:HC ratios of 0:100, 50:50, and 100:0. Solids recovery was obtained for the evaluation of the spray drying process. The cocona pulp powders were analyzed for moisture content, water activity, particle size distribution, mean particle diameter, chemical structure (FTIR) and color. For a P:CA of 1:6, for the sample formulated with hydrolyzed collagen only, solids recovery (96.2%) was much higher than that of the sample with maltodextrin only (39.2%). The chemical structure of cocona powders can be considered a sign of a good encapsulation process. The color of the cocona pulp powder was similar to that of the carrier agents. The formulation with highest content of hydrolyzed collagen improved the recovery of solids, guaranteed the cocona pulp encapsulation, and obtained fruit powders with bioactive properties.

Formulation of Dry Powder Inhaler of Anti-tuberculous Drugs Using Spray Drying Technique and Optimization Using 23 Level Factorial Design Approach

2019 ◽  
Vol 14 (3) ◽  
pp. 239-260
Author(s):  
Vaishali Thakkar ◽  
Ekta Pandey ◽  
Tosha Pandya ◽  
Purvi Shah ◽  
Asha Patel ◽  
...  
Keyword(s):  
Particle Size ◽  
Factorial Design ◽  
Spray Drying ◽  
Dry Powder Inhaler ◽  
Entrapment Efficiency ◽  
Inlet Temperature ◽  
Compatibility Study ◽  
Dry Powder ◽  
Residual Solvent ◽  
Critical Process

Background: Targeting anti-tubercular therapeutics to alveolar macrophages using microparticles technology mainly focuses on increasing local concentrations of therapeutics and potentially reducing the frequency of dosing requirements. Rifampicin (RIF), Ofloxacin (OFX) and Ethambutol (ETH) combination show synergism. Objective: In light of the above facts, the focus of the present study was to develop and characterize novel Dry powder Inhaler formulation incorporating novel drug combination as a pulmonary delivery for the effective eradication of Tuberculosis. Method: Biodegradable microparticles containing RIF, OFX and ETH were prepared by a spray drying technique using PLGA polymer through the critical process as well as polymer attributes were screened and optimized using 23 factorial design. The identified critical process parameters (CPP’s) viz. Inlet temperature, Aspiration rate, and feed rate were selected as independent variables while percentage yield, percentage entrapment efficiency, and particle size were selected as a response. The formulated microparticles were evaluated for particle size, drug-polymer compatibility study, aerodynamic behavior, morphology, particle size distribution, crystallinity, residual solvent content, in-vitro drug release study, and stability study. Results: By choosing the optimum spray drying conditions maximum yield of 73%, entrapment efficiency of 86% and particle size of 1.4 μm was attained of the optimized batch. Thus the results revealed that spherical microparticles are suitable for inhalation and sustained release for 12 h. Conclusion: The successful formulation and evaluation of dry powder could be used as an enhanced therapeutic alternative of the standard oral anti-tubercular regimen, rescuing oral dosing, shortening drug regimen and limiting toxicity. This will ultimately improve patient compliance and diminish the prevalence of MDR resistance.

Survival of Listeria monocytogenes During the Manufacture and Storage of Nonfat Dry Milk

1985 ◽  
Vol 48 (9) ◽  
pp. 740-742 ◽  
Author(s):  
MICHAEL P. DOYLE ◽  
LOUISE M. MESKE ◽  
ELMER H. MARTH
Keyword(s):  
Listeria Monocytogenes ◽  
Spray Drying ◽  
Skim Milk ◽  
Inlet Temperature ◽  
Outlet Temperature ◽  
Drying Process ◽  
Dry Milk ◽  
Nonfat Dry Milk ◽  
And Storage ◽  
Moisture Resistant

The ability of Listeria monocytogenes to survive in skim milk during spray drying and to persist in nonfat dry milk during storage was examined. Concentrated (30% solids) and unconcentrated skim milks were inoculated with ca. 105 to 106 L. monocytogenes/ml and spray dried (inlet temperature, 165 ± 2°C; outlet temperature 67 ± 2°C) to a moisture content of 3.6 to 6.4%. The nonfat dry milk was packaged in moisture-resistant film and stored at 25°C for up to 16 wk. A reduction of ca. 1 to 1.5 log10 L. monocytogenes/g occurred during the spray drying process, irrespective of whether the milk was concentrated or not before spray drying. The organism progressively died during storage at 25°C, with a &gt;4-log10 CFU/g decrease occurring within 16 wk of storage.

Process Factors Using Centrifugal Spray Drying to Prepare Bauxite Microspheres

2011 ◽  
Vol 399-401 ◽  
pp. 828-833
Author(s):  
Xiao Su Cheng ◽  
Meng Qi Peng ◽  
Yu Fa Zhong
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Spray Drying ◽  
Average Diameter ◽  
Optimal Operation ◽  
Solid Content ◽  
Diameter Distribution ◽  
Drying Process ◽  
Process Factors

The centrifugal spray drying process of bauxite slurry was studied to investigate the influence of slurry solid content on the particle size distribution and the sphericity of the microspheres, and so was operation technology on average diameter and the sphericity of the microspheres. The optimal operation parameters are obtained to prepare high spherical microspheres bauxite with the diameter distribution of 100 μm and whose particle size distribution is narrow: the slurry solid content is 70 wt%, the dry air temperature is 250 °C, the rotation rate of spray head is 6000 rpm and the feed flow rate is 1 L/h in the experiments.

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