scholarly journals Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica

2017 ◽  
Vol 7 (3) ◽  
pp. 237 ◽  
Author(s):  
Alina Stefanache ◽  
Maria Ignat ◽  
Catalina Peptu ◽  
Alina Diaconu ◽  
Iulian Stoleriu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Prolonged Release ◽  
Functionalized Mesoporous Silica ◽  
Release Drug

Functionalized Mesoporous Silica Particles for Application in Drug Delivery System

2012 ◽  
Vol 12 (8) ◽  
pp. 775-788 ◽  
Author(s):  
J. Pang ◽  
Y. Luan ◽  
X. Yang ◽  
Y. Jiang ◽  
L. Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Silica Particles ◽  
Functionalized Mesoporous Silica

scholarly journals Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential

2021 ◽  
Vol 22 (9) ◽  
pp. 4708
Author(s):  
Adrian Szewczyk ◽  
Adrianna Skwira ◽  
Agnieszka Konopacka ◽  
Rafał Sądej ◽  
Magdalena Prokopowicz
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Activity ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Amorphous Silica ◽  
Prolonged Release ◽  
Human Osteoblasts ◽  
Mcm 41

For decades, local bone drug delivery systems have been investigated in terms of their application in regenerative medicine. Among them, inorganic polymers based on amorphous silica have been widely explored. In this work, we combined two types of amorphous silica: bioglass and doxycycline-loaded mesoporous silica MCM-41 into the form of spherical granules (pellets) as a bifunctional bone drug delivery system. Both types of silica were obtained in a sol-gel method. The drug adsorption onto the MCM-41 was performed via adsorption from concentrated doxycycline hydrochloride solution. Pellets were obtained on a laboratory scale using the wet granulation-extrusion-spheronization method and investigated in terms of physical properties, drug release, antimicrobial activity against Staphylococcus aureus, mineralization properties in simulated body fluid, and cytotoxicity towards human osteoblasts. The obtained pellets were characterized by satisfactory mechanical properties which eliminated the risk of pellets cracking during further investigations. The biphasic drug release from pellets was observed: burst stage (44% of adsorbed drug released within the first day) followed by prolonged release with zero-order kinetics (estimated time of complete drug release was 19 days) with maintained antimicrobial activity. The progressive biomimetic apatite formation on the surface of the pellets was observed. No cytotoxic effect of pellets towards human osteoblasts was noticed.

scholarly journals pH-responsive mesoporous silica drug delivery system, its biocompatibility and co-adsorption/co-release of 5-Fluorouracil and Naproxen

2021 ◽  
pp. 150011
Author(s):  
Eva Benova ◽  
Virginie Hornebecq ◽  
Vladimír Zelenak ◽  
Veronika Huntosova ◽  
Miroslav Almasi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Co Adsorption ◽  
Ph Responsive
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