scholarly journals Drugs from Marine Sources

2021 ◽  
Vol 11 (24) ◽  
pp. 12115
Author(s):  
Carmela Gallo ◽  
Genoveffa Nuzzo
Keyword(s):  
Natural Products ◽  
Rich Source

Throughout history, natural products have afforded a rich source of compounds that have found many applications in the fields of pharmacology [...]

scholarly journals Natural products as a rich source of tau-targeting drugs for Alzheimer’s disease

2012 ◽  
Vol 4 (13) ◽  
pp. 1751-1761 ◽  
Author(s):  
Laurent Calcul ◽  
Bo Zhang ◽  
Umesh K Jinwal ◽  
Chad A Dickey ◽  
Bill J Baker
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Rich Source

scholarly journals Comparison of analytical techniques for the identification of bioactive compounds from natural products

2016 ◽  
Vol 33 (10) ◽  
pp. 1131-1145 ◽  
Author(s):  
Łukasz Cieśla ◽  
Ruin Moaddel
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Bioactive Compounds ◽  
Analytical Techniques ◽  
Rich Source

Natural product extracts are a rich source of bioactive compounds.

scholarly journals A Comparison of the Bioactivity of Usnic Acid versus Methylphloroacetophenone

2018 ◽  
Vol 13 (12) ◽  
pp. 1934578X1801301
Author(s):  
Ratul Sarkar ◽  
Navriti Mittal ◽  
John Sorensen ◽  
Tuhinadri Sen
Keyword(s):  
Natural Products ◽  
Antibiotic Resistance ◽  
Natural Product ◽  
Biofilm Formation ◽  
Usnic Acid ◽  
Lichen Species ◽  
Rich Source ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Acid Versus

The identification of natural products that disrupt biofilm formation has become an area of recently expanded interest in combating antibiotic resistance. The formation of biofilms has been correlated with increased pathogenesis in many strains of Gram-negative bacteria. Molecules that disrupt the formation of biofilms therefore represent a potentially novel way to combat pathogenesis. Lichen natural products are an underexplored source of biofilm disrupting natural products. We have investigated the biofilm disrupting activity of the lichen natural product usnic acid (UA) in comparison to the biosynthetic precursor methylphloroacetophenone (MPA). We have observed in our assays that UA is more bioactive than MPA, suggesting a rationale for the biosynthesis of UA in a wide variety of lichen species. These results suggest that lichen natural products may prove to be a rich source of biofilm inhibitors.

Novel natural product discovery from obligate symbiotic organisms of marine sponges

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Regina R. Monaco ◽  
Rena F. Quinlan
Keyword(s):  
Natural Products ◽  
Marine Invertebrates ◽  
Quinone Reductase ◽  
Marine Sponges ◽  
Rich Source ◽  
Bioactive Molecules ◽  
Channel Blockers ◽  
Terrestrial Plants ◽  
Technological Advances ◽  
Pharmacologically Active

A rich source for the discovery of novel, pharmacologically active natural products has been terrestrial plants and microbes, accounting for about 85% of the approved natural products in pharmaceutical use (1), and about 60% of approved pharmaceuticals and new drug applications annually (2). Discovery in the marine environment has lagged due to the difficulty of exploration in this ecological niche. Such exploration began in the 1950’s, after technological advances such as scuba diving allowed collection of marine organisms, primarily to a depth of about 15m, which was the limit of that technology.Natural products from filter feeding marine invertebrates and in particular, sponges, have proven to be a rich source of structurally unique pharmacologically active compounds, with over 16,000 molecules isolated thus far (3, 1) and a continuing pace of discovery at hundreds of novel bioactive molecules per year. All classes of pharmaceuticals have been represented in this discovery process, including antiprotozoals, pesticides, TGF-beta inhibitors, cationic channel blockers, anticancer, cytotoxic, antiviral, anti-inflammatory and antibacterial compounds. Important biosynthetic pathways found in sponges which give rise to these compounds include the terpenoid (4), fatty acid, polyketoid, quinone reductase, alkaloid, isoprenoid (5), and non-ribosomal protein synthase pathways.

Functional polysaccharides from medicinal mushroom Cordyceps sinensis as a potent food supplement: extraction, characterization and therapeutic potentials – a systematic review

RSC Advances ◽  
2015 ◽  
Vol 5 (21) ◽  
pp. 16050-16066 ◽  
Author(s):  
G. M. Shashidhar ◽  
P. Giridhar ◽  
B. Manohar
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Food Supplement ◽  
Rich Source ◽  
Cordyceps Sinensis ◽  
Medicinal Mushroom ◽  
Major Focus ◽  
Medicinal Fungi

As a rich source of novel polysaccharides, Cordyceps sinensis (CS), one of the valued traditional Chinese medicinal fungi, is a major focus of many natural products research efforts.

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